Evidence map›Paper›PMID 29028920›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2018

Perceived Fatigability and Objective Physical Activity in Mid- to Late-Life.

Amal A Wanigatunga, Eleanor M Simonsick, Vadim Zipunnikov, Adam P Spira, Stephanie Studenski, Luigi Ferrucci, Jennifer A Schrack

Open access · bronzeAbstract read
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 68 citations in OpenAlex.

  1. Hearing Impairment and Physical Activity and Physical Functioning in Older Adults: Baseline Results From the ACHIEVE Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
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  10. Validation of the Pittsburgh Performance Fatigability Index in the Study of Muscle, Mobility and Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Changes in Objectively Measured Physical Activity Are Associated With Perceived Physical and Mental Fatigability in Older Men.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022
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  16. Review
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  19. Visual Impairment and Objectively Measured Physical Activity in Middle-Aged and Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Amal A WanigatungaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Eleanor M SimonsickIntramural Research Program, National Institute on Aging, Baltimore, Maryland.
Vadim ZipunnikovDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Adam P SpiraCenter on Aging and Health, Johns Hopkins University, Baltimore, Maryland.
Stephanie StudenskiIntramural Research Program, National Institute on Aging, Baltimore, Maryland.
Luigi FerrucciIntramural Research Program, National Institute on Aging, Baltimore, Maryland.
Jennifer A SchrackDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Johns Hopkins University · USNational Institute on Aging · US

Funding

The Baltimore Longitudinal Study Of AgingZIAAG000015 · NIA · NATIONAL INSTITUTE ON AGING · PI SIMONSICK, ELEANOR MARIE · 2009 to 2025
$116.9M
Technological Assessment and Solutions Core - RC4P30AG021334 · NIA · JOHNS HOPKINS UNIVERSITY · PI Jeremy D Walston · 2003 to 2026
$33.2M
EPIDEMIOLOGY AND BIOSTATISTICS OF AGINGT32AG000247 · NIA · JOHNS HOPKINS UNIVERSITY · PI Karen J. Bandeen-Roche · 1996 to 2026
$13.2M
Stress Mental Disorders Accelerated Aging and Dementia a 35 year Cohort Study - Covid SupplementU01AG052445 · NIA · JOHNS HOPKINS UNIVERSITY · PI EATON, WILLIAM W, SPIRA, ADAM PETER · 2016 to 2021
$5.7M
The ARIC study of midlife sleep and late-life brain amyloidRF1AG050745 · NIA · JOHNS HOPKINS UNIVERSITY · PI SPIRA, ADAM PETER · 2016 to 2016
$3.8M
Poor Sleep Altered Circadian Rhythms and Alzheimers DiseaseR01AG050507 · NIA · JOHNS HOPKINS UNIVERSITY · PI SPIRA, ADAM PETER · 2015 to 2019
$2.5M
Actigraphic assessment of sleep quality in the A4 trialR01AG049872 · NIA · JOHNS HOPKINS UNIVERSITY · PI ROSENBERG, PAUL B, SPIRA, ADAM PETER · 2015 to 2019
$1.7M
Defining and Quantifying Fatigability in Functionally Independent Older AdultsR21AG053198 · NIA · JOHNS HOPKINS UNIVERSITY · PI SCHRACK, JENNIFER ANN · 2016 to 2017
$449k
NIA NIH HHS P30 AG021334NIA NIH HHS R01 AG049872NIA NIH HHS R01 AG050507NIA NIH HHS R21 AG053198NIA NIH HHS RF1 AG050745NIA NIH HHS T32 AG000247NIA NIH HHS U01 AG052445
6 · The paper itself

Abstract

Background: Fatigability, defined as fatigue in relation to a standardized task, predicts functional decline in older adults independent of reported tiredness or energy level. Although the sensation of fatigue, tiredness, and energy level adversely affect physical activity (PA), the association between fatigability and objectively measured PA is unknown. Methods: Participants in the Baltimore Longitudinal Study of Aging (n = 557, 50% women, aged 50-97 years) were instructed to wear an Actiheart accelerometer for 7 consecutive days in the free-living environment. Perceived fatigability was assessed using the Borg rating of perceived exertion (RPE) after 5 minutes of treadmill walking at 1.5 mph (0.67 m/s) and categorized as low (6-7 RPE), intermediate (8-9 RPE), and high (10+ RPE) fatigability. Time-of-day PA differences between fatigability groups were assessed using mixed-effects modeling. Results: Total daily PA was 1.3% lower for every unit increment in perceived fatigability after adjusting for demographic, behavioral, and medical factors (p = .01). In time-of-day analyses, the high fatigability group was less active compared to the low fatigability group throughout the day (8:00 am to 8:00 pm) and the intermediate fatigability group in the morning (8:00 am to 12:00 pm). Patterns of PA within the high fatigability group differed from both the intermediate and low groups in the morning but mirrored the intermediate group in the afternoon and evening. Discussion: These results suggest that RPE is a bio-marker of fatigability associated with progressively lower PA with aging. Whether the effects of fatigability occurring at the end of the day reflect waning energy levels or a voluntary choice that could be modified remains to be evaluated.

Indexed as

AccelerometryActivities of Daily LivingAgedAged, 80 and overAgingBaltimoreCircadian RhythmFatigueFemaleHumansLongitudinal StudiesMaleMiddle AgedMotor Activity

Identifiers

PMID29028920
PMCPMC5905638
OpenAlexW2755585104

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.