ArticlePloS one2017
A polyphenol-enriched diet and Ascaris suum infection modulate mucosal immune responses and gut microbiota composition in pigs.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 115 citations in OpenAlex.
- Article
- Article
- Potential Role of Brown Macroalgae on Pig Health: A Review.ACS nutrition science · 2026Review
- Fermentable fiber supplementation in pigs promotes anti-parasitic defense mechanisms and impacts parasite growth inFrontiers in immunology · 2026Article
- AdultCurrent research in parasitology & vector-borne diseases · 2026Article
- Parasite-microbiota interactions: a pathway to innovative interventions for Chagas disease, leishmaniasis, and ascariasis.Future microbiology · 2025Review
- Larval ascariasis elicits a prominent IgA and IgG1/2 antibody response to adultFrontiers in immunology · 2025Article
- Commentary: Dietary supplementation with fermented rapeseed and seaweed modulates parasite infections and gut microbiota in outdoor pigs.Frontiers in veterinary science · 2025Article
- The eubiotic perspective on utilization of tannins in phytotherapy and nutrition of pigs.Frontiers in pharmacology · 2025Review
- Dietary supplementation with fermented rapeseed and seaweed modulates parasite infections and gut microbiota in outdoor pigs.Frontiers in veterinary science · 2025Article
- The biological functions of proanthocyanidin and its application in pig production.Frontiers in veterinary science · 2025Review
- Polyphenols and Microbiota Modulation: Insights from Swine and Other Animal Models for Human Therapeutic Strategies.Molecules (Basel, Switzerland) · 2024Review
- ConcurrentmSphere · 2024Article
- Interaction between methanotrophy and gastrointestinal nematodes infection on the rumen microbiome of lambs.FEMS microbiology ecology · 2024Article
- Innate Immune-Enhancing Effect ofJournal of microbiology and biotechnology · 2024Article
- Gut Microbiota Modulators Based on Polyphenols Extracted from Winery By-Products and Their Applications in the Nutraceutical Industry.Life (Basel, Switzerland) · 2024Review
- Getting around the roundworms: Identifying knowledge gaps and research priorities for the ascarids.Advances in parasitology · 2024Article
- Article
- Dietary seaweed (Saccharina latissima) supplementation in pigs induces localized immunomodulatory effects and minor gut microbiota changes during intestinal helminth infection.Scientific reports · 2023Article
- The Effect of Prebiotic Supplements on the Gastrointestinal Microbiota and Associated Health Parameters in Pigs.Animals : an open access journal from MDPI · 2023Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyphenols are a class of bioactive plant secondary metabolites that are thought to have beneficial effects on gut health, such as modulation of mucosal immune and inflammatory responses and regulation of parasite burdens. Here, we examined the interactions between a polyphenol-rich diet supplement and infection with the enteric nematode Ascaris suum in pigs. Pigs were fed either a basal diet or the same diet supplemented with grape pomace (GP), an industrial by-product rich in polyphenols such as oligomeric proanthocyanidins. Half of the animals in each group were then inoculated with A. suum for 14 days to assess parasite establishment, acquisition of local and systemic immune responses and effects on the gut microbiome. Despite in vitro anthelmintic activity of GP-extracts, numbers of parasite larvae in the intestine were not altered by GP-supplementation. However, the bioactive diet significantly increased numbers of eosinophils induced by A. suum infection in the duodenum, jejunum and ileum, and modulated gene expression in the jejunal mucosa of infected pigs. Both GP-supplementation and A. suum infection induced significant and apparently similar changes in the composition of the prokaryotic gut microbiota, and both also decreased concentrations of isobutyric and isovaleric acid (branched-chain short chain fatty acids) in the colon. Our results demonstrate that while a polyphenol-enriched diet in pigs may not directly influence A. suum establishment, it significantly modulates the subsequent host response to helminth infection. Our results suggest an influence of diet on immune function which may potentially be exploited to enhance immunity to helminths.
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