Evidence map›Paper›PMID 29028827›Full record

ArticlePloS one2017

P. falciparum infection and maternofetal antibody transfer in malaria-endemic settings of varying transmission.

Alistair R D McLean, Danielle Stanisic, Rose McGready, Kesinee Chotivanich, Caroline Clapham, Francesca Baiwog, Mupawjay Pimanpanarak, Peter Siba, Ivo Mueller, Christopher L King and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 7 countries.

Alistair R D McLeanBurnet Institute, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0003-3449-7142
Danielle StanisicInstitute for Glycomics, Griffith University, Gold Coast Campus, Southport, Queensland, Australia.
Rose McGreadyShoklo Malaria Research Unit (SMRU), Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.
Kesinee ChotivanichDepartment of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Caroline ClaphamPapua New Guinea Institute of Medical Research, Madang, Papua New Guinea.
Francesca BaiwogPapua New Guinea Institute of Medical Research, Madang, Papua New Guinea.
Mupawjay PimanpanarakShoklo Malaria Research Unit (SMRU), Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.
Peter SibaPapua New Guinea Institute of Medical Research, Madang, Papua New Guinea.
Ivo MuellerPopulation Health & Immunity Division, WEHI, Parkville, Victoria, Australia.
Christopher L KingCenter for Global Health and Diseases, Case Western Reserve University, and Veterans Affairs Medical Center, Cleveland, OH, United States of America.
François NostenShoklo Malaria Research Unit (SMRU), Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.
James G BeesonBurnet Institute, Melbourne, Victoria, Australia.
Stephen RogersonDepartment of Medicine, University of Melbourne, Melbourne, Australia.
Julie A SimpsonCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Freya J I FowkesBurnet Institute, Melbourne, Victoria, Australia.
Mahidol University · THBurnet Institute · AUPapua New Guinea Institute of Medical Research · PGThe University of Melbourne · AUCenter for Global Health · USGriffith University · AUInstitut Pasteur · FR

Funding

Fetal Immunity to Falciparum MalariaR01AI064687 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI KING, CHRISTOPHER L · 2005 to 2015
$3.7M
NIAID NIH HHS R01 AI064687Wellcome Trust
6 · The paper itself

Abstract

introductionDuring pregnancy, immunoglobulin G (IgG) is transferred from the mother to the fetus, providing protection from disease in early infancy. Plasmodium falciparum infections may reduce maternofetal antibody transfer efficiency, but mechanisms remain unclear.

methodsMother-cord paired serum samples collected at delivery from Papua New Guinea (PNG) and the Thailand-Myanmar Border Area (TMBA) were tested for IgG1 and IgG3 to four P. falciparum antigens and measles antigen, as well as total serum IgG. Multivariable linear regression was conducted to assess the association of peripheral P. falciparum infection during pregnancy or placental P. falciparum infection assessed at delivery with maternofetal antibody transfer efficiency. Path analysis assessed the extent to which associations between P. falciparum infection and antibody transfer were mediated by gestational age at delivery or levels of maternal total serum IgG.

resultsMaternofetal antibody transfer efficiency of IgG1 and IgG3 was lower in PNG compared to TMBA (mean difference in cord antibody levels (controlling for maternal antibody levels) ranged from -0.88 to 0.09, median of -0.20 log2 units). Placental P. falciparum infections were associated with substantially lower maternofetal antibody transfer efficiency in PNG primigravid women (mean difference in cord antibody levels (controlling for maternal antibody levels) ranged from -0.62 to -0.10, median of -0.36 log2 units), but not multigravid women. The lower antibody transfer efficiency amongst primigravid women with placental infection was only partially mediated by gestational age at delivery (proportion indirect effect ranged from 0% to 18%), whereas no mediation effects of maternal total serum IgG were observed. DISCUSSION: Primigravid women may be at risk of impaired maternofetal antibody transport with placental P. falciparum infection. Direct effects of P. falciparum on the placenta, rather than earlier gestational age and elevated serum IgG, are likely responsible for the majority of the reduction in maternofetal antibody transfer efficiency with placental infection.

Indexed as

Endemic DiseasesAdolescentAdultFemaleFetal BloodGravidityHumansImmunoglobulin GMalaria, FalciparumMaternal-Fetal ExchangeMiddle AgedPlasmodium falciparumPregnancyPregnancy Complications, InfectiousYoung AdultImmunoglobulin G

Identifiers

PMID29028827
PMCPMC5640245
OpenAlexW2762922324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.