ArticlePloS one2017
Evaluation of shedding, tissue burdens, and humoral immune response in goats after experimental challenge with the virulent Brucella melitensis strain 16M and the reduced virulence vaccine strain Rev. 1.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
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- Genome-wide analysis of Brucella melitensis growth in spleen of infected mice allows rational selection of new vaccine candidates.PLoS pathogens · 2024Article
- Serological and Molecular Prevalence and Associated Risk Factors in Caprine Brucellosis, Northeastern Thailand.Veterinary medicine international · 2024Article
- Rapid and Specific Detection of B. melitensis Targeting BMEI1661 Gene Using Loop-mediated Isothermal Amplification (LAMP) Combined With Lateral Flow immunoassay (LFIA).Current microbiology · 2023Article
- Longitudinal Study of Selected Bacterial Zoonoses in Small Ruminants in Tana River County, Kenya.Microorganisms · 2022Article
- Surveillance ofVeterinary sciences · 2022Article
- Pathological changes, distribution and detection ofThe veterinary quarterly · 2021Article
- Shedding of Brucella melitensis happens through milk macrophages in the murine model of infection.Scientific reports · 2020Article
- Vaccine Candidate Brucella melitensis 16MmSphere · 2020Article
- Risk factors for acute human brucellosis in Ijara, north-eastern Kenya.PLoS neglected tropical diseases · 2020Article
- Brucella ovis mutant in ABC transporter protects against Brucella canis infection in mice and it is safe for dogs.PloS one · 2020Article
- Brucellosis in India: results of a collaborative workshop to define One Health priorities.Tropical animal health and production · 2020Article
- Brucella melitensis Rev.1 vaccination generates a higher shedding risk of the vaccine strain in Alpine ibex (Capra ibex) compared to the domestic goat (Capra hircus).Veterinary research · 2019Article
- Development of a CRISPR/Cas9 system against ruminant animal brucellosis.BMC veterinary research · 2019Article
- Whole Genome Sequencing for Tracing Geographical Origin of Imported Cases of Human Brucellosis in Sweden.Microorganisms · 2019Article
- A Cellular Model of Infection withVeterinary sciences · 2019Article
- Route of Infection Strongly Impacts the Host-Pathogen Relationship.Frontiers in immunology · 2019Article
- Seroprevalence of brucellosis in small ruminants in organized and unorganized sectors of Gujarat state, India.Veterinary world · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Brucella melitensis is the causative agent of brucellosis in small ruminants and is of considerable economic and public health importance in many countries worldwide. The control of disease in humans depends on the control of disease in livestock; however, few counties with endemic B. melitensis infection have been able to successfully eradicate this pathogen. This underscores the need for further research on the pathogenesis of both virulent and vaccine strains of B. melitensis in the small ruminant host. The aim of the present study was to characterize clinical effects, tissue colonization, shedding, and humoral immune response following B. melitensis infection in goats. Both virulent (16M) and reduced virulence (Rev. 1) strains of B. melitensis were studied. Pregnant goats were infected at 11-14 weeks of gestation with 8 x 106 or 8 x 107 CFU of B. melitensis. Infection of goats with B. melitensis 16M resulted in an 86% abortion rate. This strain disseminated widely in pregnant does post-infection with none of the 15 sampled tissues spared from colonization. Importantly, we report the first isolation of B. melitensis from muscle tissue in ruminants. Pathogenesis of Rev. 1 infection was variable with two does showing minimal colonization and one doe exhibiting disease similar to that of animals infected with fully virulent 16M. Shedding of B. melitensis in milk occurred in all 16M- and Rev. 1- infected goats. In pregnant animals challenged with virulent B. melitensis, median time to seroconversion was 21 days; however, 2 animals did not seroconvert until after abortion.
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