ArticlePLoS genetics2017
STAT, Wingless, and Nurf-38 determine the accuracy of regeneration after radiation damage in Drosophila.
Article in PLoS genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Matrix Metalloprotease 1 (Mmp1) promotes cell fate change for epithelial-to-epithelial transition during regeneration after radiation damage in Drosophila.PLoS genetics · 2026Article
- Article
- Activation of a Src-JNK pathway in unscheduled endocycling cells of the Drosophila wing disc induces a chronic wounding response.Genetics · 2025Article
- An unscheduled switch to endocycles induces a reversible senescent arrest that impairs growth of the Drosophila wing disc.PLoS genetics · 2024Article
- Wnt signaling modulates the response to DNA damage in the Drosophila wing imaginal disc by regulating the EGFR pathway.PLoS biology · 2024Article
- An unscheduled switch to endocycles induces a reversible senescent arrest that impairs growth of thebioRxiv : the preprint server for biology · 2024Article
- Regenerative growth is constrained by brain tumor to ensure proper patterning in Drosophila.PLoS genetics · 2023Article
- Imaginal Disc Regeneration: Something Old, Something New.Cold Spring Harbor perspectives in biology · 2022Review
- Misregulation of Nucleoporins 98 and 96 leads to defects in protein synthesis that promote hallmarks of tumorigenesis.Disease models & mechanisms · 2022Article
- Regulation and coordination of the different DNA damage responses inFrontiers in cell and developmental biology · 2022Review
- Differential gene expression analysis identified determinants of cell fate plasticity during radiation-induced regeneration in Drosophila.PLoS genetics · 2022Article
- A multi-gene knockdown approach reveals a new role for Pax6 in controlling organ number in Drosophila.Development (Cambridge, England) · 2021Article
- Model systems for regeneration:Development (Cambridge, England) · 2020Review
- Drug screening in Drosophila; why, when, and when not?Wiley interdisciplinary reviews. Developmental biology · 2019Review
- Article
- JAK/STAT signaling in stem cells and regeneration: fromDevelopment (Cambridge, England) · 2019Review
- What Drosophila Can Teach Us About Radiation Biology of Human Cancers.Advances in experimental medicine and biology · 2019Review
- Ionizing radiation induces stem cell-like properties in a caspase-dependent manner in Drosophila.PLoS genetics · 2018Article
- The many fates of tissue regeneration.PLoS genetics · 2018Article
- Article
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Authors and funding
2 authors.
Funding
Abstract
We report here a study of regeneration in Drosophila larval wing imaginal discs after damage by ionizing radiation. We detected faithful regeneration that restored a wing disc and abnormal regeneration that produced an extra wing disc. We describe a sequence of changes in cell number, location and fate that occur to produce an ectopic disc. We identified a group of cells that not only participate in ectopic disc formation but also recruit others to do so. STAT92E (Drosophila STAT3/5) and Nurf-38, which encodes a member of the Nucleosome Remodeling Factor complex, oppose each other in these cells to modulate the frequency of ectopic disc growth. The picture that emerges is one in which activities like STAT increase after radiation damage and fulfill essential roles in rebuilding the tissue. But such activities must be kept in check so that one and only one wing disc is regenerated.
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