Evidence map›Paper›PMID 29028543›Full record

ArticleJournal of magnetic resonance (San Diego, Calif. : 1997)2017

A pulse programmable parahydrogen polarizer using a tunable electromagnet and dual channel NMR spectrometer.

Aaron M Coffey, Roman V Shchepin, Bibo Feng, Raul D Colon, Ken Wilkens, Kevin W Waddell, Eduard Y Chekmenev

Abstract read
In one paragraph

Article in Journal of magnetic resonance (San Diego, Calif. : 1997), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. High-resolution microtesla in-situJournal of magnetic resonance (San Diego, Calif. : 1997) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Order-UnityChemphyschem : a European journal of chemical physics and physical chemistry · 2022
    Article
  7. Article
  8. PHIP hyperpolarized [1-Scientific reports · 2021
    Article
  9. Parahydrogen-Induced Radio Amplification by Stimulated Emission of Radiation.Angewandte Chemie (International ed. in English) · 2020
    Article
  10. Article
  11. Article
  12. Hyperpolarizing Concentrated MetronidazoleChemistry (Weinheim an der Bergstrasse, Germany) · 2019
    Article
  13. Relaxation Dynamics of Nuclear Long-Lived Spin States in Propane and Propane-dThe journal of physical chemistry. C, Nanomaterials and interfaces · 2019
    Article
  14. Review
  15. Effects of Deuteration ofThe journal of physical chemistry. C, Nanomaterials and interfaces · 2018
    Article
  16. Quasi-Resonance Signal Amplification by Reversible Exchange.The journal of physical chemistry letters · 2018
    Article
  17. Parahydrogen-Based Hyperpolarization for Biomedicine.Angewandte Chemie (International ed. in English) · 2018
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aaron M CoffeyVanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University, Nashville, TN 37232-2310, United States; Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232-2310, United States.
Roman V ShchepinVanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University, Nashville, TN 37232-2310, United States; Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232-2310, United States.
Bibo FengVanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University, Nashville, TN 37232-2310, United States; Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232-2310, United States.
Raul D ColonVanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University, Nashville, TN 37232-2310, United States; Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232-2310, United States.
Ken WilkensDepartment of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232-2310, United States.
Kevin W WaddellVanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University, Nashville, TN 37232-2310, United States; Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232-2310, United States.
Eduard Y ChekmenevVanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University, Nashville, TN 37232-2310, United States; Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232-2310, United States; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37232-2310, United States; Vanderbilt-Ingram Cancer Center (VICC), Vanderbilt University, Nashville, TN 37232-2310, United States; Russian Academy of Sciences, Leninskiy Prospekt 14, Moscow 119991, Russia. Electronic address: eduard.chekmenev@vanderbilt.edu.

Funding

Postdoctoral Training in Biomedical MRI and MRST32EB001628 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI John C Gore · 2003 to 2026
$7.0M
Vanderbilt In Vivo Cellular and Molecular Imaging CenterP50CA128323 · NCI · VANDERBILT UNIVERSITY · PI SHYR, YU · 2008 to 2012
$6.8M
Novel hyperpolarized C-13 and N-15 biomarkers for metabolic MR imaging of cancerR00CA134749 · NCI · VANDERBILT UNIVERSITY · PI CHEKMENEV, EDUARD · 2009 to 2011
$810k
Ultra Compact Polarizer Probe for Imaging MetabolismR21GM107947 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WADDELL, KEVIN WAYNE · 2013 to 2015
$588k
Pure parahydrogen-enhanced metabolic MRI contrast agents for molecular imagingR21EB018014 · NIBIB · SOUTHERN ILLINOIS UNIVERSITY CARBONDALE · PI CHEKMENEV, EDUARD, GOODSON, BOYD M · 2014 to 2015
$407k
NCI NIH HHS P50 CA128323NCI NIH HHS R00 CA134749NIBIB NIH HHS R21 EB018014NIBIB NIH HHS T32 EB001628NIGMS NIH HHS R21 GM107947
6 · The paper itself

Abstract

Applications of parahydrogen induced polarization (PHIP) often warrant conversion of the chemically-synthesized singlet-state spin order into net heteronuclear magnetization. In order to obtain optimal yields from the overall hyperpolarization process, catalytic hydrogenation must be tightly synchronized to subsequent radiofrequency (RF) transformations of spin order. Commercial NMR consoles are designed to synchronize applied waves on multiple channels and consequently are well-suited as controllers for these types of hyperpolarization experiments that require tight coordination of RF and non-RF events. Described here is a PHIP instrument interfaced to a portable NMR console operating with a static field electromagnet in the milliTesla regime. In addition to providing comprehensive control over chemistry and RF events, this setup condenses the PHIP protocol into a pulse-program that in turn can be readily shared in the manner of traditional pulse sequences. In this device, a TTL multiplexer was constructed to convert spectrometer TTL outputs into 24 VDC signals. These signals then activated solenoid valves to control chemical shuttling and reactivity in PHIP experiments. Consolidating these steps in a pulse-programming environment speeded calibration and improved quality assurance by enabling the B

Indexed as

MagnetsElectromagnetic FieldsHydrogenHydrogenationMagnetic Resonance SpectroscopyRadio WavesReproducibility of ResultsHydrogen(13)CHyperpolarizationInstrumentationLow fieldNMRParahydrogenSpectroscopy

Identifiers

PMID29028543
PMCPMC5708540

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.