Evidence map›Paper›PMID 29028437›Full record

ArticleJournal of child and adolescent psychopharmacology2018

Stimulants Do Not Increase the Risk of Seizure-Related Hospitalizations in Children with Epilepsy.

Xinyue Liu, Paul R Carney, Regina Bussing, Richard Segal, Linda B Cottler, Almut G Winterstein

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of child and adolescent psychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xinyue Liu1 Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida , Gainesville, Florida.
Paul R Carney2 Department of Neurology, School of Medicine, The University of North Carolina at Chapel Hill , Chapel Hill, North Carolina.
Regina Bussing3 Department of Psychiatry, College of Medicine, University of Florida , Gainesville, Florida.
Richard Segal1 Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida , Gainesville, Florida.
Linda B Cottler4 Department of Epidemiology, Colleges of Medicine and Public Health and Health Professions, University of Florida , Gainesville, Florida.
Almut G Winterstein1 Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida , Gainesville, Florida.
University of Florida · USUniversity of North Carolina at Chapel Hill · US

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8M
NIA NIH HHS P30 AG028740
6 · The paper itself

Abstract

objectiveTo evaluate the safety of stimulants in children with epilepsy.

methodsIn a retrospective cohort study based on Medicaid Analytic eXtract billing records from 26 U.S. states from 1999 to 2010, we identified incident stimulant use among children with epilepsy through outpatient encounter claims and pharmacy claims. We established a control group of nonusers and used frequency matching to generate index dates. We followed both cohorts for 12 months and calculated hazard ratios [HRs] of current and former use of stimulants versus no use on the outcome of seizure-related hospitalization using multivariate Cox proportional hazard models.

resultsWe identified 18,166 stimulant users and 54,197 nonusers in children with epilepsy. The incidence of seizure-related hospitalization in current stimulant users, former users, and nonusers was 3.6, 3.5, and 4.3 per 100 patient-years. After adjustment for confounders, we found current and former use of stimulants did not increase seizure-related hospitalizations (HR 0.95, 95% confidence interval [CI]: 0.83, 1.09 and HR 0.99, 95% CI: 0.85, 1.15). Children with cerebral palsy, congenital nervous system anomalies, or intellectual disability did not have significantly higher HRs than those without the already mentioned comorbidities.

conclusionThis study has not identified any overall increase in the rate of seizure-related hospitalizations with the use of stimulants in children with epilepsy.

Indexed as

AdolescentCentral Nervous System StimulantsChildChild, PreschoolCohort StudiesEpilepsyFemaleHospitalizationHumansIncidenceMaleMedicaidProportional Hazards ModelsRetrospective StudiesSeizuresUnited StatesCentral Nervous System StimulantsADHDchildrenepilepsyMedicaidsafetystimulants

Identifiers

PMID29028437
PMCPMC5911707
OpenAlexW2762801646

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.