ArticleThe ISME journal2018
Cyanophage-encoded lipid desaturases: oceanic distribution, diversity and function.
Article in The ISME journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- A cold-responsiveApplied and environmental microbiology · 2026Article
- Salinity-driven shifts in estuarine viral community composition and diversity near the Shenzhen coast.Applied and environmental microbiology · 2025Article
- Virocell resource manipulation under nutrient limitation.mSystems · 2025Article
- Identification of Shemin pathway genes for tetrapyrrole biosynthesis in bacteriophage sequences from aquatic environments.Nature communications · 2024Article
- Viral Infection Leads to a Unique Suite of Allelopathic Chemical Signals in Three Diatom Host-Virus Pairs.Marine drugs · 2024Article
- Functional analysis of the dehydratase domains of the PUFA synthase from Emiliania huxleyi in Escherichia coli and Arabidopsis thaliana.Biotechnology for biofuels and bioproducts · 2022Article
- Growth Substrate and Prophage Induction Collectively Influence Metabolite and Lipid Profiles in a Marine Bacterium.mSystems · 2022Article
- Protist impacts on marine cyanovirocell metabolism.ISME communications · 2022Article
- Genetic engineering of marine cyanophages reveals integration but not lysogeny in T7-like cyanophages.The ISME journal · 2022Article
- Cryo-EM structure of a tetrameric photosystem I fromPlant communications · 2022Article
- A Novel Broad Host Range Phage InfectingViruses · 2021Article
- Prophage Genomics and Ecology in the FamilyMicroorganisms · 2021Article
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- Viral Ecogenomics of Arctic Cryopeg Brine and Sea Ice.mSystems · 2020Article
- Integrated mobile genetic elements in Thaumarchaeota.Environmental microbiology · 2019Article
- The Genome Sequence of a Novel Cyanophage S-B64 from the Yellow Sea, China.Current microbiology · 2019Article
- Cyanophage MazG is a pyrophosphohydrolase but unable to hydrolyse magic spot nucleotides.Environmental microbiology reports · 2019Article
- Infection by a Giant Virus (AaV) Induces Widespread Physiological Reprogramming inFrontiers in microbiology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyanobacteria are among the most abundant photosynthetic organisms in the oceans; viruses infecting cyanobacteria (cyanophages) can alter cyanobacterial populations, and therefore affect the local food web and global biochemical cycles. These phages carry auxiliary metabolic genes (AMGs), which rewire various metabolic pathways in the infected host cell, resulting in increased phage fitness. Coping with stress resulting from photodamage appears to be a central necessity of cyanophages, yet the overall mechanism is poorly understood. Here we report a novel, widespread cyanophage AMG, encoding a fatty acid desaturase (FAD), found in two genotypes with distinct geographical distribution. FADs are capable of modulating the fluidity of the host's membrane, a fundamental stress response in living cells. We show that both viral FAD (vFAD) families are Δ9 lipid desaturases, catalyzing the desaturation at carbon 9 in C16 fatty acid chains. In addition, we present a comprehensive fatty acid profiling for marine cyanobacteria, which suggests a unique desaturation pathway of medium- to long-chain fatty acids no longer than C16, in accordance with the vFAD activity. Our findings suggest that cyanophages are capable of fiddling with the infected host's membranes, possibly leading to increased photoprotection and potentially enhancing viral-encoded photosynthetic proteins, resulting in a new viral metabolic network.
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