Evidence map›Paper›PMID 29027958›Full record

ReviewInternational journal of molecular sciences2017

Adipose Tissue as a Strategic Source of Mesenchymal Stem Cells in Bone Regeneration: A Topical Review on the Most Promising Craniomaxillofacial Applications.

Francesco Paduano, Massimo Marrelli, Massimiliano Amantea, Carlo Rengo, Sandro Rengo, Michel Goldberg, Gianrico Spagnuolo, Marco Tatullo

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

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  14. Stem cells and common biomaterials in dentistry: a review study.Journal of materials science. Materials in medicine · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Francesco PaduanoORCID 0000-0003-0916-8101
Massimo MarrelliUnit of Craniomaxillofacial Surgery, Calabrodental, 88900 Crotone, Italy. research@tecnologicasrl.com.
Massimiliano AmanteaUnit of Experimental Medicine, Marrelli Hospital, 88900 Crotone, Italy. massimiliano.amantea@calabrodental.it.
Carlo RengoDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", 80138 Naples, Italy. carlorengo@alice.it.
Sandro RengoDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", 80138 Naples, Italy. sanrengo@unina.it.
Michel GoldbergProfesseur Emerite, Biomédicale des Saints Pères, Université Paris Descartes, Institut National de la Santé et de la Recherche Médicale UMR-S 1124, 75654 Paris, France. michel.goldberg@parisdescartes.fr.
Gianrico SpagnuoloDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples "Federico II", 80138 Naples, Italy. gianrico.spagnuolo@gmail.com.
Marco TatulloBiomedical Section, Stem Cells Unit, Tecnologica Research Institute, 88900 Crotone, Italy. marco.tatullo@tecnologicasrl.com.ORCID 0000-0001-7340-0708

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone regeneration in craniomaxillofacial surgery represents an issue that involves both surgical and aesthetic aspects. The most recent studies on bone tissue engineering involving adipose-derived stromal/stem cells (ASCs) have clearly demonstrated that such cells can play a crucial role in the treatment of craniomaxillofacial defects, given their strong commitment towards the osteogenic phenotype. A deeper knowledge of the molecular mechanisms underlying ASCs is crucial for a correct understanding of the potentialities of ASCs-based therapies in the most complex maxillofacial applications. In this topical review, we analyzed the molecular mechanisms of ASCs related to their support toward angiogenesis and osteogenesis, during bone regeneration. Moreover, we analyzed both case reports and clinical trials reporting the most promising clinical applications of ASCs in the treatment of craniomaxillofacial defects. Our study aimed to report the main molecular and clinical features shown by ASCs, used as a therapeutic support in bone engineering, as compared to the use of conventional autologous and allogeneic bone grafts.

Indexed as

Bone RegenerationMesenchymal Stem Cell TransplantationAdipose TissueAnimalsClinical Trials as TopicCraniofacial AbnormalitiesHumansMesenchymal Stem CellsOsteogenesisProteomeTissue EngineeringTissue ScaffoldsTranscriptomeProteomeadipose-derived stromal/stem cells (ASCs)bone defectsbone tissue engineeringclinical trialscraniomaxillofacial bone defectsmolecular mechanismsurgical reconstruction

Identifiers

PMID29027958
PMCPMC5666822

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.