Evidence map›Paper›PMID 29027957›Full record

ArticleMolecules (Basel, Switzerland)2017

Peroxisomal 2-Hydroxyacyl-CoA Lyase Is Involved in Endogenous Biosynthesis of Heptadecanoic Acid.

Benjamin Jenkins, Evelyn de Schryver, Paul P. Van Veldhoven, Albert Koulman

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. A Novel Function of Nonadecanoic Acid in Regulating Glucose Homeostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Benjamin JenkinsNIHR BRC Core Metabolomics and Lipidomics Laboratory, University of Cambridge, Pathology building Level 4, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK. BJJ25@medschl.cam.ac.uk.
Evelyn de SchryverLaboratory of Lipid Biochemistry and Protein Interactions (LIPIT), Campus Gasthuisberg-KU Leuven, Herestraat Box 601, B-3000 Leuven, Belgium. evelyndeschryver@hotmail.com.
Paul P. Van VeldhovenLaboratory of Lipid Biochemistry and Protein Interactions (LIPIT), Campus Gasthuisberg-KU Leuven, Herestraat Box 601, B-3000 Leuven, Belgium. paul.vanveldhoven@med.kuleuven.be.
Albert KoulmanNIHR BRC Core Metabolomics and Lipidomics Laboratory, University of Cambridge, Pathology building Level 4, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK. AK675@medschl.cam.ac.uk.
KU Leuven · BEMRC Human Nutrition Research · GB

Funding

Medical Research Council G0800783
6 · The paper itself

Abstract

Circulating heptadecanoic acid (C17:0) is reported to be a pathology risk/prognosis biomarker and a dietary biomarker. This pathology relationship has been shown to be reliably predictive even when independent of dietary contributions, suggesting that the endogenous biosynthesis of C17:0 is related to the pathological aetiology. Little is known about C17:0 biosynthesis, which tissues contribute to the circulating levels, and how C17:0 is related to pathology.

Indexed as

Adipose TissueAnimalsCarbon-Carbon LyasesEnoyl-CoA HydrataseFatty AcidsHumansLiverMiceMice, KnockoutOxidation-ReductionPeroxisomesTissue DistributionCarbon-Carbon LyasesEnoyl-CoA HydrataseFatty AcidsHACL1 protein, humanHacl1 protein, mousemargaric acidalpha-oxidationbiomarkerC17:0Hacl1heptadecanoic acidodd chain fatty acidpentadecanoic acidperoxisomes

Identifiers

PMID29027957
PMCPMC6151664
OpenAlexW2761352538

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.