Evidence map›Paper›PMID 29027901›Full record

ArticleeLife2017

Structure of RNA polymerase bound to ribosomal 30S subunit.

Gabriel Demo, Aviram Rasouly, Nikita Vasilyev, Vladimir Svetlov, Anna B Loveland, Ruben Diaz-Avalos, Nikolaus Grigorieff, Evgeny Nudler, Andrei A Korostelev

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 104 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. How Dedicated Ribosomes Translate a Leaderless mRNA.Journal of molecular biology · 2024
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. The Structural Dynamics of Translation.Annual review of biochemistry · 2022
    Review
  11. AnBio-protocol · 2022
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Transcription regulates ribosome hibernation.Molecular microbiology · 2021
    Article
  18. Review
  19. Article
  20. The intricate relationship between transcription and translation.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Gabriel Demo *RNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, United States.ORCID http://orcid.org/0000-0002-5472-9249
Aviram Rasouly *Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, United States.
Nikita VasilyevDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, United States.
Vladimir SvetlovDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, United States.
Anna B LovelandRNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, United States.
Ruben Diaz-AvalosJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
Nikolaus GrigorieffJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID http://orcid.org/0000-0002-1506-909X
Evgeny NudlerDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, United States.ORCID https://orcid.org/0000-0002-8811-3071
Andrei A KorostelevRNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, United States.ORCID http://orcid.org/0000-0003-1588-717X
Howard Hughes Medical Institute · USUniversity of Massachusetts Chan Medical School · USNew York University · US

Funding

Role of RNA polymerase in DNA stability and repairR01GM107329 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NUDLER, EVGENY A · 2014 to 2017
$1.7M
Structural bases for cellular stress responses mediated by stalled translationR01GM106105 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KOROSTELEV, ANDREI · 2013 to 2017
$1.6M
Molecular principles of translation terminationR01GM107465 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KOROSTELEV, ANDREI · 2015 to 2018
$1.3M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM106105NIGMS NIH HHS R01 GM107329NIGMS NIH HHS R01 GM107465
6 · The paper itself

Abstract

In bacteria, mRNA transcription and translation are coupled to coordinate optimal gene expression and maintain genome stability. Coupling is thought to involve direct interactions between RNA polymerase (RNAP) and the translational machinery. We present cryo-EM structures of

Indexed as

Cryoelectron MicroscopyDNA-Directed RNA PolymerasesEscherichia coliEscherichia coli ProteinsModels, MolecularProtein BindingProtein ConformationRibosomal ProteinsRibosome Subunits, Small, BacterialDNA-Directed RNA PolymerasesEscherichia coli ProteinsRibosomal Proteinsribosomal protein S1, E coli30S subunitbiochemistrybiophysicscouplingcryo-EME. coliRNA polymerasestructural biologytranscriptiontranslation

Identifiers

PMID29027901
PMCPMC5655137
OpenAlexW2761125101

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.