Evidence map›Paper›PMID 29027713›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2017

Engineering Cell Surface Function with DNA Origami.

Ehsan Akbari, Molly Y Mollica, Christopher R Lucas, Sarah M Bushman, Randy A Patton, Melika Shahhosseini, Jonathan W Song, Carlos E Castro

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed.

  1. Article
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  4. Article
  5. Article
  6. Article
  7. Review
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  9. Review
  10. Review
  11. Article
  12. DNA-programmed cell assembly: from cells, tissues to organoids.Frontiers in bioengineering and biotechnology · 2025
    Review
  13. Review
  14. Article
  15. Gamma rays impact on 2D-MoSScientific reports · 2024
    Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. High spatial-resolved heat manipulating membrane heterogeneity alters cellular migration and signaling.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ehsan AkbariDepartment of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, 43210, USA.
Molly Y MollicaDepartment of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, 43210, USA.
Christopher R LucasDepartment of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, 43210, USA.
Sarah M BushmanDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, 43210, USA.
Randy A PattonDepartment of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, 43210, USA.
Melika ShahhosseiniDepartment of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, 43210, USA.
Jonathan W SongDepartment of Mechanical and Aerospace Engineering, The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH, 43210, USA.
Carlos E CastroDepartment of Mechanical and Aerospace Engineering, Biophysics Graduate Program, The Ohio State University, Columbus, OH, 43210, USA.ORCID http://orcid.org/0000-0001-7023-6105

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Tasleem J Padamsee · 1985 to 2026
$132.3M
ONOCOLOGY TRAINING GRANTT32CA009338 · NCI · OHIO STATE UNIVERSITY · PI BYRD, JOHN C., POLLOCK, RAPHAEL E. · 1985 to 2018
$8.3M
NCI NIH HHS P30 CA016058NCI NIH HHS T32 CA009338
6 · The paper itself

Abstract

A specific and reversible method is reported to engineer cell-membrane function by embedding DNA-origami nanodevices onto the cell surface. Robust membrane functionalization across epithelial, mesenchymal, and nonadherent immune cells is achieved with DNA nanoplatforms that enable functions including the construction of higher-order DNA assemblies at the cell surface and programed cell-cell adhesion between homotypic and heterotypic cells via sequence-specific DNA hybridization. It is anticipated that integration of DNA-origami nanodevices can transform the cell membrane into an engineered material that can mimic, manipulate, and measure biophysical and biochemical function within the plasma membrane of living cells.

Indexed as

Cell MembraneDNAEngineeringNanostructuresNanotechnologyNucleic Acid ConformationDNAcell surface engineeringDNA nanotechnologyDNA origamiintercellular adhesionmembrane functionalization

Identifiers

PMID29027713
PMCPMC5739518

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.