ReviewJournal of separation science2018
Optimizing separations in online comprehensive two-dimensional liquid chromatography.
Review in Journal of separation science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed.
- Resolving charge and glycosylation variants of cetuximab combining offline ion-exchange and hydrophilic interaction chromatography-HRMS.Analytical and bioanalytical chemistry · 2026Article
- Using comprehensive two-dimensional liquid chromatography to unveil and mitigate the bidirectional quantification biases of non-volatile compounds in Chinese black tea processing.Food chemistry: X · 2026Article
- A Protocol for Characterizing Comprehensive Two-Dimensional Liquid Chromatography Systems.Journal of separation science · 2026Article
- Development and Validation of an Isocratic HPLC Method for the Simultaneous Determination of Avobenzone and Tris-Biphenyl Triazine.ACS omega · 2026Article
- Screening and optimization of online comprehensive two-dimensional liquid chromatography conditions for the analysis of hospital wastewater.Analytical and bioanalytical chemistry · 2026Article
- Rapid and Simplified Determination of Amphetamine-Type Stimulants Using One-Pot Synthesized Magnetic Adsorbents with Built-In pH Regulation Coupled with Liquid Chromatography-Tandem Mass Spectrometry.Journal of xenobiotics · 2025Article
- From Complexity to Clarity: Expanding Metabolome Coverage With Innovative Analytical Strategies.Journal of separation science · 2025Review
- Different chromatographic techniques and recent advancements for biomedical and pharmaceutical applications.Northern clinics of Istanbul · 2025Article
- Comprehensive Two-Dimensional Liquid Chromatography-High-Resolution Mass Spectrometry for Complex Protein Digest Analysis Using Parallel Gradients.Analytical chemistry · 2024Article
- Sample transformation in online separations: how chemical conversion advances analytical technology.Chemical communications (Cambridge, England) · 2023Review
- Two-Dimensional High-Performance Liquid Chromatography as a Powerful Tool for Bioanalysis: The Paradigm of Antibiotics.Molecules (Basel, Switzerland) · 2023Review
- Theoretical and practical comparison of RPLC and RPLC × RPLC: how to consider dilution effects and sensitivity in addition to separation power?Analytical and bioanalytical chemistry · 2023Article
- A Novel Two-Dimensional Liquid Chromatography Combined with Ultraviolet Detection Method for Quantitative Determination of Pyridoxal 5'-Phosphate, 4-Pyridoxine Acid and Pyridoxal in Animal Plasma.Animals : an open access journal from MDPI · 2023Article
- Targeted Small-Molecule Identification Using Heartcutting Liquid Chromatography-Infrared Ion Spectroscopy.Analytical chemistry · 2023Article
- Article
- Chemometric Strategies for Fully Automated Interpretive Method Development in Liquid Chromatography.Analytical chemistry · 2022Article
- Differentiation of industrial hemp strains by their cannabinoid and phenolic compounds using LC × LC-HRMS.Analytical and bioanalytical chemistry · 2022Article
- Phytochemical Characterization ofMolecules (Basel, Switzerland) · 2022Article
- Characterisation of a new online nanoLC-CZE-MS platform and application for the glycosylation profiling of alpha-1-acid glycoprotein.Analytical and bioanalytical chemistry · 2022Article
- Latest Trends on the Future of Three-Dimensional Separations in Chromatography.Chemical reviews · 2021Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Online comprehensive two-dimensional liquid chromatography has become an attractive option for the analysis of complex nonvolatile samples found in various fields (e.g. environmental studies, food, life, and polymer sciences). Two-dimensional liquid chromatography complements the highly popular hyphenated systems that combine liquid chromatography with mass spectrometry. Two-dimensional liquid chromatography is also applied to the analysis of samples that are not compatible with mass spectrometry (e.g. high-molecular-weight polymers), providing important information on the distribution of the sample components along chemical dimensions (molecular weight, charge, lipophilicity, stereochemistry, etc.). Also, in comparison with conventional one-dimensional liquid chromatography, two-dimensional liquid chromatography provides a greater separation power (peak capacity). Because of the additional selectivity and higher peak capacity, the combination of two-dimensional liquid chromatography with mass spectrometry allows for simpler mixtures of compounds to be introduced in the ion source at any given time, improving quantitative analysis by reducing matrix effects. In this review, we summarize the rationale and principles of two-dimensional liquid chromatography experiments, describe advantages and disadvantages of combining different selectivities and discuss strategies to improve the quality of two-dimensional liquid chromatography separations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.