Evidence map›Paper›PMID 29027112›Full record

SynthesisMolecular neurobiology2018

Field Synopsis and Re-analysis of Systematic Meta-analyses of Genetic Association Studies in Multiple Sclerosis: a Bayesian Approach.

Jae Hyon Park, Joo Hi Kim, Kye Eun Jo, Se Whan Na, Michael Eisenhut, Andreas Kronbichler, Keum Hwa Lee, Jae Il Shin

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Surprising magic of CD24 beyond cancer.Frontiers in immunology · 2023
    Review
  4. Article
  5. Article
  6. Novel Association betweenIndian journal of dermatology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jae Hyon ParkSeverance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Joo Hi KimYonsei University Wonju College of Medicine, Seoul, Republic of Korea.
Kye Eun JoCollege of Medicine, University of Debrecen, Debrecen, Hungary.
Se Whan NaYonsei University Wonju College of Medicine, Seoul, Republic of Korea.
Michael EisenhutDepartment of Pediatrics, Luton & Dunstable University Hospital NHS Foundation Trust, Luton, UK.
Andreas KronbichlerDepartment of Internal Medicine IV, Medical University Innsbruck, Innsbruck, Austria.
Keum Hwa LeeDepartment of Pediatrics, Yonsei University College of Medicine, 50 Yonsei-Ro, Seodaemun-Gu, Seoul, 120-752, Republic of Korea.
Jae Il ShinDepartment of Pediatrics, Yonsei University College of Medicine, 50 Yonsei-Ro, Seodaemun-Gu, Seoul, 120-752, Republic of Korea. shinji@yuhs.ac.ORCID http://orcid.org/0000-0003-2326-1820

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To provide an up-to-date summary of multiple sclerosis-susceptible gene variants and assess the noteworthiness in hopes of finding true associations, we investigated the results of 44 meta-analyses on gene variants and multiple sclerosis published through December 2016. Out of 70 statistically significant genotype associations, roughly a fifth (21%) of the comparisons showed noteworthy false-positive rate probability (FPRP) at a statistical power to detect an OR of 1.5 and at a prior probability of 10

Indexed as

Genetic Association StudiesGenetic Predisposition to DiseaseBayes TheoremGene Regulatory NetworksHumansMultiple SclerosisPolymorphism, GeneticBFDPFPRPGene variantMeta-analysisMultiple sclerosis

Identifiers

PMID29027112

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.