ArticleMetabolic brain disease2018
Walnut supplementation reverses the scopolamine-induced memory impairment by restoration of cholinergic function via mitigating oxidative stress in rats: a potential therapeutic intervention for age related neurodegenerative disorders.
Article in Metabolic brain disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 37 citations in OpenAlex.
- One-year dietary supplementation with walnuts modifies exosomal miRNA in elderly subjects.European journal of nutrition · 2021Trial
- Investigating the protective effect of zinc oxide-gallic acid nanoparticles against depression like behavior and memory impairment in animals treated with D-galactose.Scientific reports · 2026Article
- A Review of Antioxidant Activity, Anti-Inflammatory Properties, Apoptosis-Regulatory Effects, and Immune System Modulation ofFood science & nutrition · 2025Review
- Walnut oil: a promising nutraceutical in reducing oxidative stress and improving cholinergic activity in anToxicology research · 2024Article
- Mitochondrial dysfunction in chronic neuroinflammatory diseases (Review).International journal of molecular medicine · 2024Review
- Neuroprotective effects of walnutIranian journal of basic medical sciences · 2024Review
- Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia.Antioxidants (Basel, Switzerland) · 2023Article
- Pharmacotherapeutic potential of walnut (Juglans spp.) in age-related neurological disorders.IBRO neuroscience reports · 2023Review
- Variations in Antioxidant Capacity, Oxidative Stability, and Physicochemical Quality Parameters of Walnut (Molecules (Basel, Switzerland) · 2022Article
- Investigating walnut consumption and cognitive trajectories in a representative sample of older US adults.Public health nutrition · 2021Observational
- Anti-Amnesic Effect of Walnut via the Regulation of BBB Function and Neuro-Inflammation in AβAntioxidants (Basel, Switzerland) · 2020Article
- Amelioration of motor and non-motor deficits and increased striatal APoE levels highlight the beneficial role of pistachio supplementation in rotenone-induced rat model of PD.Metabolic brain disease · 2020Article
- Neuroprotective effects of matrine on scopolamine-induced amnesia via inhibition of AChE/BuChE and oxidative stress.Metabolic brain disease · 2019Article
- Dietary Supplementation of Almond Prevents Oxidative Stress by Advocating Antioxidants and Attenuates Impaired Aversive Memory in Male Rats.Plant foods for human nutrition (Dordrecht, Netherlands) · 2018Article
- Walnut Supplementation in the Diet Reduces Oxidative Damage and Improves Antioxidant Status in Transgenic Mouse Model of Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2018Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brain is highly susceptible to the damaging effects of oxidative reactive species. The free radicals which are produced as a consequence of aerobic respiration can cause cumulative oxygen damage which may lead to age-related neurodegeneration. Scopolamine, the anti-muscarinic agent, induces amnesia and oxidative stress similar to that observed in the older age. Studies suggest that antioxidants derived from plant products may provide protection against oxidative stress. Therefore, the present study was designed to investigate the attenuation of scopolamine-induced memory impairment and oxidative stress by walnut supplementation in rats. Rats in test group were administrated with walnut suspension (400 mg/kg/day) for four weeks. Both control and walnut-treated rats were then divided into saline and scopolamine-treated groups. Rats in the scopolamine group were injected with scopolamine (0.5 mg/kg dissolved in saline) five minutes before the start of each memory test. Memory was assessed by elevated plus maze (EPM), Morris water maze (MWM), and novel object recognition task (NOR) followed by estimation of regional acetylcholine levels and acetylcholinesterase activity. In the next phase, brain oxidative status was determined by assaying lipid peroxidation, and measuring superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) activities. Results showed that scopolamine-treatment impaired memory function, caused cholinergic dysfunction, and induced oxidative stress in rats compared to that saline-treated controls. These impairments were significantly restored by pre-administration of walnut. This study demonstrates that antioxidant properties of walnut may provide augmented effects on cholinergic function by reducing oxidative stress and thus improving memory performance.
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