SynthesisArchives of women's mental health2018
A systematic review of maternal antidepressant use in pregnancy and short- and long-term offspring's outcomes.
Synthesis in Archives of women's mental health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 5 syntheses or guidelines pooled it, 50 citations in OpenAlex.
- Interventions to Prevent Relapse or Recurrence of Preconception Anxiety and/or Depression in Perinatal Women: A Systematic Review.Maternal and child health journal · 2025Pooled it
- Prenatal medication exposure and epigenetic outcomes: a systematic literature review and recommendations for prenatal pharmacoepigenetic studies.Epigenetics · 2022Pooled it
- Antidepressant Use During Pregnancy and the Potential Risks of Motor Outcomes and Intellectual Disabilities in Offspring: A Systematic Review.Drugs - real world outcomes · 2021Pooled it
- Repetitive transcranial magnetic stimulation treatment for peripartum depression: systematic review & meta-analysis.BMC pregnancy and childbirth · 2021Pooled it
- Long-Term Effects of Intrauterine Exposure to Antidepressants on Physical, Neurodevelopmental, and Psychiatric Outcomes: A Systematic Review.The Journal of clinical psychiatry · 2020Pooled it
- Non-pharmacological interventions for the management of perinatal anxiety in primary care: a meta-review of systematic reviews.BJGP open · 2023Article
- Antidepressants use during pregnancy and child psychomotor, cognitive and language development at 2 years of age-Results from the 3D Cohort Study.Frontiers in pharmacology · 2023Article
- Low reliability of DNA methylation across Illumina Infinium platforms in cord blood: implications for replication studies and meta-analyses of prenatal exposures.Clinical epigenetics · 2022Article
- The German Guidelines for the treatment of anxiety disorders: first revision.European archives of psychiatry and clinical neuroscience · 2022Article
- The approach to managing perinatal anxiety: A mini-review.Frontiers in psychiatry · 2022Review
- Maternal deaths by suicide in Queensland, Australia, 2004-2017: an analysis of maternal demographic, psychosocial and clinical characteristics.Archives of women's mental health · 2021Article
- Contemporary management of unipolar depression in the perinatal period.Expert review of neurotherapeutics · 2021Article
- Prenatal antidepressant exposure and neurodevelopmental problems in children: to get the right answer, we must ask the right question.Pediatric research · 2021Article
- Hypertensive disorders in pregnancy and child development at 36 months in the All Our Families prospective cohort study.PloS one · 2021Article
- Treating Anxiety During Pregnancy: Patient Concerns About Pharmaceutical Treatment.Maternal and child health journal · 2020Article
- The effect of antenatal depression and antidepressant treatment on placental tissue: a protein-validated gene expression study.BMC pregnancy and childbirth · 2019Article
- Trend of antidepressants before, during, and after pregnancy across two decades-A population-based study.Brain and behavior · 2019Article
- Are Antidepressant Medications Safe for Pregnant Women With Epilepsy? The Signs Point to Yes.Epilepsy currentsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relative safety of antidepressants during pregnancy has received substantial attention, but most syntheses fail to account for mental illness effects. We aimed to evaluate the literature comparing low birth weight (LBW) and neurodevelopmental and neurobehavioural outcomes for children whose mothers took antidepressants in pregnancy compared to those whose mothers had common mental disorders, or symptoms, but who did not take antidepressants during pregnancy. A systematic review was conducted searching PubMed, MEDLINE, PsycINFO and Embase in January 2015. A modified version of the Newcastle Ottawa Scale was used to assess study quality. Eleven cohort studies were included: four reporting a LBW outcome (all with higher risk of bias) and seven reporting a neurodevelopmental outcome (five with higher risk of bias). We found only limited evidence of gestational age-adjusted LBW in exposed children in two studies which had a higher risk of bias and did not control for depressive symptom severity. Only five (7.5%) neurodevelopmental outcomes and one (12.5%) neurobehavioural outcome showed evidence of a statistically significant effect, three out of four were from studies with a higher risk of bias. There is little robust evidence indicating a detrimental effect of antidepressant use during pregnancy on LBW and neurodevelopmental and neurobehavioural outcomes. More rigorous study designs are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.