Evidence map›Paper›PMID 29026688›Full record

ReviewWorld journal of methodology2017

Establishing the presence or absence of chronic kidney disease: Uses and limitations of formulas estimating the glomerular filtration rate.

Ahmed Alaini, Deepak Malhotra, Helbert Rondon-Berrios, Christos P Argyropoulos, Zeid J Khitan, Dominic S C Raj, Mark Rohrscheib, Joseph I Shapiro, Antonios H Tzamaloukas

Open access · diamondAbstract readReview
In one paragraph

Review in World journal of methodology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 65 citations in OpenAlex.

  1. Efficacy and Safety of Romosozumab Among Postmenopausal Women With Osteoporosis and Mild-to-Moderate Chronic Kidney Disease.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022
    Trial
  2. Leveraging Multiomic Signatures to Predict Body Composition.Advances in nutrition (Bethesda, Md.) · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ahmed AlainiDivision of Nephrology, Department of Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131, United States.
Deepak MalhotraDivision of Nephrology, Department of Medicine, University of Toledo School of Medicine, Toledo, OH 43614-5809, United States.
Helbert Rondon-BerriosRenal and Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, United States.
Christos P ArgyropoulosDivision of Nephrology, Department of Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131, United States.
Zeid J KhitanDivision of Nephrology, Department of Medicine, Joan C. Edwards School of Medicine, Huntington, WV 25701, United States.
Dominic S C RajDivision of Nephrology, Department of Medicine, George Washington University, Washington, DC 20037, United States.
Mark RohrscheibDivision of Nephrology, Department of Medicine, University of New Mexico School of Medicine, Albuquerque, NM 87131, United States.
Joseph I ShapiroMarshall University Joan C. Edwards School of Medicine, Huntington, WV 25701, United States.
Antonios H TzamaloukasNephrology Section, Medicine Service, Raymond G. Murphy VA Medical Center, Albuquerque, NM 87108, United States.
University of New Mexico · US

Funding

CORAL: Clinical Coordinating CenterU01HL071556 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI COOPER, CHRISTOPHER J · 2004 to 2013
$19.3M
Cytokine Gene Polymorphism in CRIC CohortR01DK073665 · NIDDK · UNIVERSITY OF NEW MEXICO · PI RAJ, DOMINIC S · 2006 to 2010
$2.3M
Receptor Na/K-ATPase Antagonists As Novel Therapeutics For Renal/Cardiac DiseasesR01HL109015 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI SHAPIRO, JOSEPH ISAAC, XIE, ZIJIAN · 2011 to 2014
$2.2M
Gut Microbiota and Atherosclerosis in ESRDU01DK099914 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI RAJ, DOMINIC S · 2013 to 2017
$1.9M
Na/K-ATPase Reduction in Renal Disease-Related Cardiac DysfunctionR01HL105649 · NHLBI · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI TIAN, JIANG · 2012 to 2016
$1.8M
REGULATION OF APICAL ENDOCYTOSIS BY ARF6 AND PLDF32DK009924 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI SANTY, LORRAINE C. · 1999 to 2001
$83k
NHLBI NIH HHS R01 HL105649NHLBI NIH HHS R01 HL109015NHLBI NIH HHS U01 HL071556NIDDK NIH HHS F32 DK009924NIDDK NIH HHS R01 DK073665NIDDK NIH HHS U01 DK099914
6 · The paper itself

Abstract

The development of formulas estimating glomerular filtration rate (eGFR) from serum creatinine and cystatin C and accounting for certain variables affecting the production rate of these biomarkers, including ethnicity, gender and age, has led to the current scheme of diagnosing and staging chronic kidney disease (CKD), which is based on eGFR values and albuminuria. This scheme has been applied extensively in various populations and has led to the current estimates of prevalence of CKD. In addition, this scheme is applied in clinical studies evaluating the risks of CKD and the efficacy of various interventions directed towards improving its course. Disagreements between creatinine-based and cystatin-based eGFR values and between eGFR values and measured GFR have been reported in various cohorts. These disagreements are the consequence of variations in the rate of production and in factors, other than GFR, affecting the rate of removal of creatinine and cystatin C. The disagreements create limitations for all eGFR formulas developed so far. The main limitations are low sensitivity in detecting early CKD in several subjects,

Indexed as

Biomarkers of chronic kidney diseaseChronic kidney diseaseCreatinine clearanceCreatinine excretionCystatin CEstimated glomerular filtration rateHyperfiltrationRenal imagingSerum creatinine

Identifiers

PMID29026688
PMCPMC5618145
OpenAlexW2757059420

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.