ArticleUnited European gastroenterology journal2017
Flow cytometry of duodenal intraepithelial lymphocytes improves diagnosis of celiac disease in difficult cases.
Article in United European gastroenterology journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- European Society for the Study of Coeliac Disease 2025 Updated Guidelines on the Diagnosis and Management of Coeliac Disease in Adults. Part 1: Diagnostic Approach.United European gastroenterology journal · 2025Guideline
- Pooled it
- The Usefulness of Intraepithelial Lymphocyte Immunophenotype Testing for the Diagnosis of Coeliac Disease in Clinical Practice.Nutrients · 2024Article
- Intraepithelial Lymphogram in the Diagnosis of Celiac Disease in Adult Patients: A Validation Cohort.Nutrients · 2024Article
- IL-10-producing regulatory cells impact on celiac disease evolution.Clinical immunology (Orlando, Fla.) · 2024Article
- Single cell transcriptomic analysis of the immune cell compartment in the human small intestine and in Celiac disease.Nature communications · 2022Article
- Intestinal and blood lymphograms as new diagnostic tests for celiac disease.Frontiers in immunology · 2022Review
- Diagnosis of coeliac disease by flow cytometry of intraepithelial lymphocytes: a new 'gold' standard?Frontline gastroenterology · 2022Article
- Emerging Biomarkers for Screening and Management of Celiac Disease.BioMed research international · 2022Review
- Insight in the diagnosis and treatment of coeliac disease in general practice: A survey and case vignette study among 106 general practitioners.The European journal of general practice · 2021Article
- The Diagnostic Utility of Flow Cytometry in Celiac Disease Presented Isolated Iron Deficiency Anemia.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2021Article
- Deciphering the Transcriptomic Heterogeneity of Duodenal Coeliac Disease Biopsies.International journal of molecular sciences · 2021Article
- More fuel to the fire: some patients with non-celiac self-reported wheat sensitivity exhibit adaptive immunological responses in duodenal mucosa.BMC gastroenterology · 2020Article
- Pathogenesis of Celiac Disease and Other Gluten Related Disorders in Wheat and Strategies for Mitigating Them.Frontiers in nutrition · 2020Review
- Improving basic skills in celiac-like disease diagnosis: a case report.BMC gastroenterology · 2018Article
- An Overview of Celiac Disease in Childhood Type 1 Diabetes.International journal of endocrinology and metabolism · 2018Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiagnosis of celiac disease is difficult when the combined results of serology and histology are inconclusive. Studies using flow cytometry of intraepithelial lymphocytes (IELs) have found that celiac patients have increased numbers of γδ IELs, along with a decrease in CD3-CD103 + IELs.
objectiveThe objective of this article is to assess the role of flow cytometric analysis of IELs in the diagnosis of celiac disease in difficult cases.
methodsA total of 312 patients with suspicion of celiac disease were included in the study. Duodenal biopsy samples were used for histological assessment and for flow cytometric analysis of IELs.
resultsIn 46 out of 312 cases (14.7%) the combination of serology and histology did not allow the confirmation or exclusion of celiac disease. HLA typing had been performed in 42 of these difficult cases. Taking into account HLA typing and the response to a gluten-free diet, celiac disease was excluded in 30 of these cases and confirmed in the remaining 12. Flow cytometric analysis of IELs allowed a correct diagnosis in 39 out of 42 difficult cases (92.8%) and had a sensitivity of 91.7% (95% CI: 61.5% to 99.8%) and a specificity of 93.3% (95% CI: 77.9% to 99.2%) for the diagnosis of celiac disease in this setting.
conclusionFlow cytometric analysis of IELs is useful for the diagnosis of celiac disease in difficult cases.
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