Evidence map›Paper›PMID 29026563›Full record

ArticleClinical case reports2017

Methotrexate-induced leukoencephalopathy presenting as stroke in the emergency department.

Maria Teresa Cruz-Carreras, Patrick Chaftari, Anna Shamsnia, Nandita Guha-Thakurta, Carmen Gonzalez

Abstract readCase Reports
In one paragraph

Article in Clinical case reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
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  4. Article
  5. Review
  6. Article
  7. Article
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  9. Review
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  11. Article
  12. Methotrexate-induced toxic leukoencephalopathy: an uncommon stroke mimic.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maria Teresa Cruz-CarrerasDepartment of Emergency Medicine The University of Texas MD Anderson Cancer Center Houston Texas.ORCID 0000-0002-2019-5322
Patrick ChaftariDepartment of Emergency Medicine The University of Texas MD Anderson Cancer Center Houston Texas.
Anna ShamsniaDepartment of Emergency Medicine The University of Texas MD Anderson Cancer Center Houston Texas.
Nandita Guha-ThakurtaDepartment of Emergency Medicine The University of Texas MD Anderson Cancer Center Houston Texas.
Carmen GonzalezDepartment of Emergency Medicine The University of Texas MD Anderson Cancer Center Houston Texas.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methotrexate-induced leukoencephalopathy is to be considered as a potential etiology in any patient presenting with stroke-like symptoms after receiving methotrexate. One of our cases suggests that the method of administration of the methotrexate can be IV or intrathecal and still results in leukoencephalopathy.

Indexed as

Acute lymphocytic leukemiafocal weaknessintrathecal methotrexatemethotrexate‐induced leukoencephalopathyneurotoxic side effects

Identifiers

PMID29026563
PMCPMC5628205

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.