ArticleProceedings of the National Academy of Sciences of the United States of America1988
Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 154 citations in OpenAlex.
- A meta-analysis of somatic mutations from next generation sequencing of 241 melanomas: a road map for the study of genes with potential clinical relevance.Molecular cancer therapeutics · 2014Pooled it
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- Selective Impairment of Rod-Driven Vision in Vitamin A Deficiency: Insights From Examining the Effect of Desensitizing Backgrounds.Investigative ophthalmology & visual science · 2025Article
- Venous Thrombosis in a Pseudohypoparathyroidism Patient with a Novel GNAS Frameshift Mutation and Complete Resolution of Vascular Calcifications with Acetazolamide Treatment.Hormone research in paediatrics · 2024Article
- Review
- Estrogen and G protein-coupled estrogen receptor accelerate the progression of benign prostatic hyperplasia by inducing prostatic fibrosis.Cell death & disease · 2022Article
- A complex pheotype in a girl with a novel heterozygous missense variant (p.Ile56Phe) of the GNAS gene.Orphanet journal of rare diseases · 2022Article
- A Novel Platelet-Related Gene Signature for Predicting the Prognosis of Triple-Negative Breast Cancer.Frontiers in cell and developmental biology · 2021Article
- Methylation changes at theWorld journal of gastrointestinal oncology · 2020Article
- Identification of a novel mutation in pseudohypoparathyroidism type Ia in a Chinese family: A case report.Medicine · 2020Article
- Pseudohypoparathyroidism: one gene, several syndromes.Journal of endocrinological investigation · 2017Review
- Gnaz couples the circadian and dopaminergic system to G protein-mediated signaling in mouse photoreceptors.PloS one · 2017Article
- A Novel T55A Variant of Gs α Associated with Impaired cAMP Production, Bone Fragility, and Osteolysis.Case reports in endocrinology · 2016Article
- GNAS Spectrum of Disorders.Current osteoporosis reports · 2015Review
- The GNAS complex locus and human diseases associated with loss-of-function mutations or epimutations within this imprinted gene.Hormone research in paediatrics · 2013Review
- The GNAS Locus: Quintessential Complex Gene Encoding Gsalpha, XLalphas, and other Imprinted Transcripts.Current genomics · 2007Article
- Machine learning approaches to supporting the identification of photoreceptor-enriched genes based on expression data.BMC bioinformatics · 2006Article
- Mutations in the cone photoreceptor G-protein alpha-subunit gene GNAT2 in patients with achromatopsia.American journal of human genetics · 2002Article
- Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes.Genome research · 1998Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A variety of genes have been identified that specify the synthesis of the components of guanine nucleotide-binding proteins (G proteins). Eight different guanine nucleotide-binding alpha-subunit proteins, two different beta subunits, and one gamma subunit have been described. Hybridization of cDNA clones with DNA from human-mouse somatic cell hybrids was used to assign many of these genes to human chromosomes. The retinal-specific transducin subunit genes GNAT1 and GNAT2 were on chromosomes 3 and 1; GNAI1, GNAI2, and GNAI3 were assigned to chromosomes 7, 3, and 1, respectively; GNAZ and GNAS were found on chromosomes 22 and 20. The beta subunits were also assigned--GNB1 to chromosome 1 and GNB2 to chromosome 7. Restriction fragment length polymorphisms were used to map the homologues of some of these genes in the mouse. GNAT1 and GNAI2 were found to map adjacent to each other on mouse chromosome 9 and GNAT2 was mapped on chromosome 17. The mouse GNB1 gene was assigned to chromosome 19. These mapping assignments will be useful in defining the extent of the G alpha gene family and may help in attempts to correlate specific genetic diseases with genes corresponding to G proteins.
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