ArticleNature communications2017
A long-range cis-regulatory element for class I odorant receptor genes.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Vertebrate-wide transcriptomic screening identifies immune cell-specific expression of the conserved OR-κ gene.Zoological letters · 2026Article
- An epigenetic repressor TRIM66 dictates monogenic olfactory receptor expression, neural activity, and olfactory behavior.Nature communications · 2025Article
- A common mechanism of singular gene choice is revealed by broadly expressed odorant receptor transgenes within the olfactory epithelium.Cell reports · 2025Article
- Determinants of odorant receptor transcription and gene choice.Chemical senses · 2025Review
- Establishment and maintenance of random monoallelic expression.Development (Cambridge, England) · 2024Review
- Epigenetic programming of stochastic olfactory receptor choice.Genesis (New York, N.Y. : 2000) · 2024Review
- Localized Expression of Olfactory Receptor Genes in the Olfactory Organ of Common Minke Whales.International journal of molecular sciences · 2024Article
- Olfactory receptor choice: a case study for gene regulation in a multi-enhancer system.Current opinion in genetics & development · 2022Review
- Olfactory receptor coding sequences cause silencing of episomal constructs in multiple cell lines.Molecular and cellular neurosciences · 2021Article
- Coordination of two enhancers drives expression of olfactory trace amine-associated receptors.Nature communications · 2021Article
- Olfactory expression of trace amine-associated receptors requires cooperative cis-acting enhancers.Nature communications · 2021Article
- Co-Regulated Genes and Gene Clusters.Genes · 2021Review
- Bcl11b is required for proper odorant receptor expression in the mouse septal organ.Cell and tissue research · 2021Article
- A class I odorant receptor enhancer shares a functional motif with class II enhancers.Scientific reports · 2021Article
- Genetic Background Effects on the Expression of an Odorant Receptor Gene.Frontiers in cellular neuroscience · 2021Article
- Regulatory sharing between estrogen receptor α bound enhancers.Nucleic acids research · 2020Article
- A unified nomenclature for vertebrate olfactory receptors.BMC evolutionary biology · 2020Article
- Runx-mediated regulation of CCL5 via antagonizing two enhancers influences immune cell function and anti-tumor immunity.Nature communications · 2020Article
- Bioinformatics Discovery of Putative Enhancers within Mouse Odorant Receptor Gene Clusters.Chemical senses · 2019Article
- A purely bioinformatic pipeline for the prediction of mammalian odorant receptor gene enhancers.BMC bioinformatics · 2019Article
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9 authors.
Funding
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Abstract
Individual olfactory sensory neurons express a single odorant receptor gene from either class I genes residing in a single cluster on a single chromosome or class II genes spread over multiple clusters on multiple chromosomes. Here, we identify an enhancer element for mouse class I genes, the J element, that is conserved through mammalian species from the platypus to humans. The J element regulates most class I genes expression by exerting an effect over ~ 3 megabases within the whole cluster. Deletion of the trans J element increases the expression frequencies of class I genes from the intact J allele, indicating that the allelic exclusion of class I genes depends on the activity of the J element. Our data reveal a long-range cis-regulatory element that governs the singular class I gene expression and has been phylogenetically preserved to retain a single cluster organization of class I genes in mammals."Each olfactory sensory neuron expresses a single odorant receptor gene from either class I or class II genes. Here, the authors identify an enhancer for mouse class I genes, that is highly conserved, and regulates most class I genes expression by acting over ~ 3 megabases within the whole cluster."
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