Evidence map›Paper›PMID 29025987›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2018

Preclinical Development of CD38-Targeted [

Anchal Ghai, Dolonchampa Maji, Nicholas Cho, Chantiya Chanswangphuwana, Michael Rettig, Duanwen Shen, John DiPersio, Walter Akers, Farrokh Dehdashti, Samuel Achilefu and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 73 citations in OpenAlex.

  1. Article
  2. Article
  3. PET Imaging of CD38 and IND enabling studies of [Molecular imaging and biology · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Evaluating TcAs for Use in Biotechnology Applications.Biotech (Basel (Switzerland)) · 2025
    Article
  8. Review
  9. Article
  10. Article
  11. CD38 as theranostic target in oncology.Journal of translational medicine · 2024
    Review
  12. Article
  13. Article
  14. Development of a [89Zr]Zr-labeled Human Antibody using a Novel Phage-displayed Human scFv Library.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Article
  15. CD46-Targeted Theranostics for PET and 225Ac-Radiopharmaceutical Therapy of Multiple Myeloma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024
    Article
  16. Review
  17. ACS omega · 2023
    Article
  18. First-in-Humans Evaluation of Safety and Dosimetry ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  19. Article
  20. Research progress in the role of CD38 in clinical tumor treatment.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Anchal GhaiDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Dolonchampa MajiDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Nicholas ChoDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Chantiya ChanswangphuwanaDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Michael RettigDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Duanwen ShenDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
John DiPersioDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Walter AkersCenter for In Vivo Imaging and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee; and.
Farrokh DehdashtiDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Samuel AchilefuDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Ravi VijDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Monica ShokeenDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri mshokeen@wustl.edu.
Washington University in St. Louis · USSt. Jude Children's Research Hospital · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
Project 2 - Radiation-Induced Treatment of Multiple Myeloma using NanoparticlesU54CA199092 · NCI · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2015 to 2019
$11.5M
21ST CENTURY IMAGING SCIENCES: GRADUATE STUDENT TRAININGT32EB014855 · NIBIB · WASHINGTON UNIVERSITY · PI JOSEPH P CULVER, JOSEPH A O'SULLIVAN · 2012 to 2026
$3.1M
Exploring CD38 molecular biology and imaging in multiple myeloma pathogenesisR01CA248493 · NCI · WASHINGTON UNIVERSITY · PI SHOKEEN, MONICA · 2020 to 2024
$3.1M
DEVELOPMENT OF GOGGLE SYSTEM FOR FLUORESCENCE IMAGE-GUIDED SURGERYR01CA171651 · NCI · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2013 to 2017
$2.8M
NANOPHOTOSENSITIZERS FOR REGENERATIVE PHOTOTHERAPY OF TUMORSR01EB021048 · NIBIB · WASHINGTON UNIVERSITY · PI ACHILEFU, SAMUEL · 2015 to 2020
$2.3M
BM NICHE DISRUPTION AND IMMUNOTHERAPY IN HEMATOLOGICAL MALIGNANCIESR50CA211466 · NCI · WASHINGTON UNIVERSITY · PI Michael Rettig · 2016 to 2026
$2.3M
RECEPTOR TARGETED MOLECULAR IMAGING OF MULTIPLE MYELOMAR01CA176221 · NCI · WASHINGTON UNIVERSITY · PI SHOKEEN, MONICA · 2013 to 2015
$946k
NCI NIH HHS P30 CA091842NCI NIH HHS R01 CA171651NCI NIH HHS R01 CA176221NCI NIH HHS R01 CA248493NCI NIH HHS R50 CA211466NCI NIH HHS U54 CA199092NIBIB NIH HHS R01 EB021048NIBIB NIH HHS T32 EB014855
6 · The paper itself

Abstract

Multiple myeloma (MM) is a plasma B-cell hematologic cancer that causes significant skeletal morbidity. Despite improvements in survival, heterogeneity in response remains a major challenge in MM. Cluster of differentiation 38 (CD38) is a type II transmembrane glycoprotein overexpressed in myeloma cells and is implicated in MM cell signaling. Daratumumab is a U.S. Food and Drug Administration-approved high-affinity monoclonal antibody targeting CD38 that is clinically benefiting refractory MM patients. Here, we evaluated [

Indexed as

RadioisotopesZirconiumADP-ribosyl Cyclase 1AnimalsAntibodies, MonoclonalCell Line, TumorHumansIsotope LabelingMiceMultiple MyelomaPositron Emission Tomography Computed TomographyTissue DistributionADP-ribosyl Cyclase 1Antibodies, MonoclonaldaratumumabRadioisotopesZirconiumZirconium-89[89Zr]Zr-DFO-daratumumabcluster of differentiation 38 (CD38)molecular imagingmultiple myeloma (MM)

Identifiers

PMID29025987
PMCPMC5807532
OpenAlexW2764160420

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.