Evidence map›Paper›PMID 29025969›Full record

ArticleJournal of cell science2017

A versatile optical tool for studying synaptic GABA

Joshua M Lorenz-Guertin, Madeleine R Wilcox, Ming Zhang, Mads B Larsen, Jyotsna Pilli, Brigitte F Schmidt, Marcel P Bruchez, Jon W Johnson, Alan S Waggoner, Simon C Watkins and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cell science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Diazepam Accelerates GABAFrontiers in cellular neuroscience · 2019
    Article
  9. γ2 GABAFrontiers in cellular neuroscience · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Joshua M Lorenz-GuertinDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Madeleine R WilcoxDepartment of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Ming ZhangDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA.ORCID http://orcid.org/0000-0001-6988-9272
Mads B LarsenDepartment of Cell Biology, Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Jyotsna PilliDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA.ORCID http://orcid.org/0000-0002-6623-0883
Brigitte F SchmidtMolecular Biosensor and Imaging Center, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Marcel P BruchezDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Jon W JohnsonDepartment of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Alan S WaggonerDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA.
Simon C WatkinsDepartment of Cell Biology, Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Tija C JacobDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15213, USA tcj11@pitt.edu.ORCID http://orcid.org/0000-0002-8288-7885

Funding

Permeation, Block, and Gating of NMDA ReceptorsR01MH045817 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHNSON, JON W. · 1997 to 2017
$5.0M
PREDOCTORAL TRAINING IN PHARMACOLOGICAL SCIENCEST32GM008424 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PAGANO, PATRICK J · 1994 to 2019
$3.4M
NIGMS NIH HHS T32 GM008424NIMH NIH HHS R01 MH045817
6 · The paper itself

Abstract

Live-cell imaging methods can provide critical real-time receptor trafficking measurements. Here, we describe an optical tool to study synaptic γ-aminobutyric acid (GABA) type A receptor (GABA

Indexed as

AnimalsEndosomesFluorescence Resonance Energy TransferHEK293 CellsHumansLysosomesMicroscopy, FluorescenceNeuronsProtein TransportRats, Sprague-DawleyReceptors, GABA-ARecombinant Fusion ProteinsSingle-Cell AnalysisReceptors, GABA-ARecombinant Fusion ProteinsFluorogen-activating peptideGABA type A receptorPharmacologySynapseTrafficking

Identifiers

PMID29025969
PMCPMC5702044

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.