ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017
Strength of Temporal White Matter Pathways Predicts Semantic Learning.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Trial
- Disrupted white matter functional connectivity in post-stroke cognitive impairment: Insights from resting-state fMRI.Brain imaging and behavior · 2026Article
- Impaired semantic word learning in primary progressive aphasia.Brain structure & function · 2026Article
- White matter connectivity linked to novel word learning in children.Brain structure & function · 2024Article
- Associative white matter tracts selectively predict sensorimotor learning.Communications biology · 2024Article
- To sleep or not to sleep? No effect of sleep on contextual word learning in younger adults.Quarterly journal of experimental psychology (2006) · 2024Article
- The right uncinate fasciculus supports verbal short-term memory in aphasia.Brain structure & function · 2023Article
- Comparing human and chimpanzee temporal lobe neuroanatomy reveals modifications to human language hubs beyond the frontotemporal arcuate fasciculus.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Structural connectivity in ventral language pathways characterizes non-verbal autism.Brain structure & function · 2022Article
- Graphomotor memory in Exner's area enhances word learning in the blind.Communications biology · 2021Article
- Second Language Learning in Older Adults: Effects on Brain Structure and Predictors of Learning Success.Frontiers in aging neuroscience · 2021Article
- Language development and brain reorganization in a child born without the left hemisphere.Cortex; a journal devoted to the study of the nervous system and behavior · 2020Article
- Diffusion Tensor Imaging Abnormalities in the Uncinate Fasciculus and Inferior Longitudinal Fasciculus in Phelan-McDermid Syndrome.Pediatric neurology · 2020Observational
- The role of the fornix in human navigational learning.Cortex; a journal devoted to the study of the nervous system and behavior · 2020Article
- Pharmacotherapy of Traumatic Childhood Aphasia: Beneficial Effects of Donepezil Alone and Combined With Intensive Naming Therapy.Frontiers in pharmacology · 2020Article
- The impact of expressive language development and the left inferior longitudinal fasciculus on listening and reading comprehension.Journal of neurodevelopmental disorders · 2019Article
- Observational
- Spontaneous synchronization to speech reveals neural mechanisms facilitating language learning.Nature neuroscience · 2019Article
- White-matter pathways and semantic processing: intrasurgical and lesion-symptom mapping evidence.NeuroImage. Clinical · 2019Article
- Performance and Function Meet Structure: A White Matter Connection Tuned for Vocal Production.Brain connectivity · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Learning the associations between words and meanings is a fundamental human ability. Although the language network is cortically well defined, the role of the white matter pathways supporting novel word-to-meaning mappings remains unclear. Here, by using contextual and cross-situational word learning, we tested whether learning the meaning of a new word is related to the integrity of the language-related white matter pathways in 40 adults (18 women). The arcuate, uncinate, inferior-fronto-occipital and inferior-longitudinal fasciculi were virtually dissected using manual and automatic deterministic fiber tracking. Critically, the automatic method allowed assessing the white matter microstructure along the tract. Results demonstrate that the microstructural properties of the left inferior-longitudinal fasciculus predict contextual learning, whereas the left uncinate was associated with cross-situational learning. In addition, we identified regions of special importance within these pathways: the posterior middle temporal gyrus, thought to serve as a lexical interface and specifically related to contextual learning; the anterior temporal lobe, known to be an amodal hub for semantic processing and related to cross-situational learning; and the white matter near the hippocampus, a structure fundamental for the initial stages of new-word learning and, remarkably, related to both types of word learning. No significant associations were found for the inferior-fronto-occipital fasciculus or the arcuate. While previous results suggest that learning new phonological word forms is mediated by the arcuate fasciculus, these findings show that the temporal pathways are the crucial neural substrate supporting one of the most striking human abilities: our capacity to identify correct associations between words and meanings under referential indeterminacy.
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