Evidence map›Paper›PMID 29025923›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

Plasticity of Signaling by Spinal Estrogen Receptor α, κ-Opioid Receptor, and Metabotropic Glutamate Receptors over the Rat Reproductive Cycle Regulates Spinal Endomorphin 2 Antinociception: Relevance of Endogenous-Biased Agonism.

Nai-Jiang Liu, Vijaya Murugaiyan, Emiliya M Storman, Stephen A Schnell, Arjun Kumar, Martin W Wessendorf, Alan R Gintzler

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Arbiters of endogenous opioid analgesia: role of CNS estrogenic and glutamatergic systems.Translational research : the journal of laboratory and clinical medicine · 2021
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Estrogen Regulation of GRK2 Inactivates Kappa Opioid Receptor Signaling Mediating Analgesia, But Not Aversion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Nai-Jiang LiuDepartment of Obstetrics and Gynecology, State University of New York, Downstate Medical Center, Brooklyn, New York 11203, and.ORCID 0000-0003-2738-3147
Vijaya MurugaiyanDepartment of Obstetrics and Gynecology, State University of New York, Downstate Medical Center, Brooklyn, New York 11203, and.ORCID 0000-0001-7617-8794
Emiliya M StormanDepartment of Obstetrics and Gynecology, State University of New York, Downstate Medical Center, Brooklyn, New York 11203, and.ORCID 0000-0002-6654-9499
Stephen A SchnellDepartment of Neuroscience, School of Medicine, University of Minnesota, Minneapolis, Minnesota 55455.ORCID 0000-0002-3237-3042
Arjun KumarDepartment of Obstetrics and Gynecology, State University of New York, Downstate Medical Center, Brooklyn, New York 11203, and.
Martin W WessendorfDepartment of Neuroscience, School of Medicine, University of Minnesota, Minneapolis, Minnesota 55455.ORCID 0000-0003-4471-9909
Alan R GintzlerDepartment of Obstetrics and Gynecology, State University of New York, Downstate Medical Center, Brooklyn, New York 11203, and alan.gintzler@downstate.edu.
State University of New York · USUniversity of Minnesota · US

Funding

Alternatives to prescription opioids: a precision medicine approach to harnessing endogenous opioids for pain relief and circumvention of prescription opioid abuseR01DA043774 · NIDA · SUNY DOWNSTATE MEDICAL CENTER · PI LIU, NAIJIANG, STEWART, MARK G · 2017 to 2021
$1.8M
Sex-dependent expression and utilization of spinal mu- and kappa-opioid systemsR01DA027663 · NIDA · SUNY DOWNSTATE MEDICAL CENTER · PI GINTZLER, ALAN R, LIU, NAIJIANG · 2010 to 2014
$1.3M
NIDA NIH HHS R01 DA027663NIDA NIH HHS R01 DA043774
6 · The paper itself

Abstract

We previously showed that intrathecal application of endomorphin 2 [EM2; the highly specific endogenous μ-opioid receptor (MOR) ligand] induces antinociception that varies with stage of the rat estrous cycle: minimal during diestrus and prominent during proestrus. Earlier studies, however, did not identify proestrus-activated signaling strategies that enable spinal EM2 antinociception. We now report that in female rats, increased spinal dynorphin release and κ-opioid receptor (KOR) signaling, as well as the emergence of glutamate-activated metabotropic glutamate receptor 1 (mGluR

Indexed as

AnimalsEstrogen Receptor alphaEstrous CycleFemaleNeuronal PlasticityNociceptionOligopeptidesPain MeasurementRatsRats, Sprague-DawleyReceptors, Metabotropic GlutamateReceptors, Opioid, kappaReproductionSignal TransductionSpinal Cordendomorphin 2Estrogen Receptor alphametabotropic glutamate receptor type 1OligopeptidesReceptors, Metabotropic GlutamateReceptors, Opioid, kappaantinociceptionbiased agonismdynorphinendomorphin 2estrous cycleκ-opioid receptor

Identifiers

PMID29025923
PMCPMC5688526
OpenAlexW2763112552

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.