Evidence map›Paper›PMID 29025907›Full record

ArticleHaematologica2018

Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells' vulnerability to DNA-damaging agents.

Antonia Cagnetta, Debora Soncini, Stefania Orecchioni, Giovanna Talarico, Paola Minetto, Fabio Guolo, Veronica Retali, Nicoletta Colombo, Enrico Carminati, Marino Clavio and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Haematologica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 62 citations in OpenAlex.

  1. Article
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  8. Article
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  13. Article
  14. Review
  15. Review
  16. Emerging Therapeutic Potential of SIRT6 Modulators.Journal of medicinal chemistry · 2021
    Review
  17. Article
  18. Targeting DNA Damage Repair Functions of Two Histone Deacetylases, HDAC8 and SIRT6, Sensitizes Acute Myeloid Leukemia to NAMPT Inhibition.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 6 institutions in 2 countries.

Antonia CagnettaChair of Hematology, Department of Internal Medicine (DiMI), University of Genova, Italy.
Debora SonciniChair of Hematology, Department of Internal Medicine (DiMI), University of Genova, Italy.
Stefania OrecchioniEuropean Institute of Oncology, Milan, Italy.
Giovanna TalaricoEuropean Institute of Oncology, Milan, Italy.
Paola MinettoChair of Hematology, Department of Internal Medicine (DiMI), University of Genova, Italy.
Fabio GuoloChair of Hematology, Department of Internal Medicine (DiMI), University of Genova, Italy.
Veronica RetaliChair of Hematology, Department of Internal Medicine (DiMI), University of Genova, Italy.
Nicoletta ColomboChair of Hematology, Department of Internal Medicine (DiMI), University of Genova, Italy.
Enrico CarminatiChair of Hematology, Department of Internal Medicine (DiMI), University of Genova, Italy.
Marino ClavioChair of Hematology, Department of Internal Medicine (DiMI), University of Genova, Italy.
Maurizio MiglinoChair of Hematology, Department of Internal Medicine (DiMI), University of Genova, Italy.
Micaela BergamaschiChair of Hematology, Department of Internal Medicine (DiMI), University of Genova, Italy.
Aimable NahimanaService and Central Laboratory of Hematology, University Hospital of Lausanne, Switzerland.
Michel DuchosalService and Central Laboratory of Hematology, University Hospital of Lausanne, Switzerland.
Katia TodoertiLaboratory of Pre-Clinical and Translational Research, IRCCS-CROB, Referral Cancer Center of Basilicata, Rionero in Vulture, Potenza, Italy.
Antonino NeriDepartment of Oncology and Hemato-Oncology, University of Milan, Italy.
Mario PassalacquaDepartment of Experimental Medicine, University of Genova, Italy and.
Santina BruzzoneDepartment of Experimental Medicine, University of Genova, Italy and.
Alessio NencioniHematology Unit, Policlinico San Martino, Genova, Italy.
Francesco BertoliniEuropean Institute of Oncology, Milan, Italy.
Marco GobbiChair of Hematology, Department of Internal Medicine (DiMI), University of Genova, Italy.
Roberto M LemoliChair of Hematology, Department of Internal Medicine (DiMI), University of Genova, Italy.
Michele CeaChair of Hematology, Department of Internal Medicine (DiMI), University of Genova, Italy michele.cea@unige.it.
University of Genoa · ITOspedale Policlinico San Martino · ITEuropean Institute of Oncology · ITUniversity of Lausanne · CHCentro di Riferimento Oncologico della Basilicata · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genomic instability plays a pathological role in various malignancies, including acute myeloid leukemia (AML), and thus represents a potential therapeutic target. Recent studies demonstrate that SIRT6, a NAD

Indexed as

AnimalsAntineoplastic AgentsAtaxia Telangiectasia Mutated ProteinsBiomarkers, TumorCell Line, TumorCell ProliferationCheckpoint Kinase 2Disease Models, AnimalDNA DamageDNA RepairEnzyme ActivationGene ExpressionGenomic InstabilityHumansImmunophenotypingLeukemia, Myeloid, AcuteAntineoplastic AgentsAtaxia Telangiectasia Mutated ProteinsATM protein, humanBiomarkers, TumorCheckpoint Kinase 2CHEK2 protein, humanSIRT6 protein, humanSirtuins

Identifiers

PMID29025907
PMCPMC5777193
OpenAlexW2764279662

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.