ArticleThe European respiratory journal2017
Characterisation of asthma subgroups associated with circulating YKL-40 levels.
Article in The European respiratory journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 56 citations in OpenAlex.
- Different Inflammatory Phenotypes and Immune Endotypes Drive Disease Heterogeneity in Asthma and COPD.Clinical reviews in allergy & immunology · 2026Review
- Integrated molecular networks reveal latent components distinguishing type 2-high and type 2-low asthma.BMJ open respiratory research · 2026Article
- Systemic-airway eosinophil discordance and sputum mediator profiling in severe asthma treated with biologics: a retrospective cohort study.BMC pulmonary medicine · 2026Article
- Stability of Type 2 Inflammation in a 12-Year Adult-Onset Asthma Follow-Up Study.Journal of asthma and allergy · 2026Article
- Evaluating the Influence ofBiomolecules · 2025Article
- Computational Phenotyping of Obstructive Airway Diseases: A Systematic Review.Journal of asthma and allergy · 2025Review
- YKL-40 as a possible marker of neutrophilic asthma.Frontiers in medicine · 2023Review
- Chitinase-3-like 1 regulates TFrontiers in immunology · 2023Article
- Molecular Clustering Analysis of Blood Biomarkers in World Trade Center Exposed Community Members with Persistent Lower Respiratory Symptoms.International journal of environmental research and public health · 2022Article
- Differences in Inflammatory Cytokine Profile in Obesity-Associated Asthma: Effects of Weight Loss.Journal of clinical medicine · 2022Article
- Increased Plasma YKL-40 Level and Chitotriosidase Activity in Cystic Fibrosis Patients.Inflammation · 2022Article
- Difference of Serum Cytokine Profile in Allergic Asthma Patients According to Disease Severity.Journal of asthma and allergy · 2022Article
- Adenovirus vector-mediated YKL-40 shRNA attenuates eosinophil airway inflammation in a murine asthmatic model.Gene therapy · 2021Article
- Chitinase 3-like-1 protects airway function despite promoting type 2 inflammation during fungal-associated allergic airway inflammation.American journal of physiology. Lung cellular and molecular physiology · 2021Article
- YKL-40 is a proposed biomarker of inflammation and remodelling elevated in children with bronchopulmonary dysplasia compared to asthma.Acta paediatrica (Oslo, Norway : 1992) · 2021Article
- Natural polymorphism of Ym1 regulates pneumonitis through alternative activation of macrophages.Science advances · 2020Article
- Characterization of a Murine Model of Oxazolone-Induced Orbital Inflammation.Translational vision science & technology · 2020Article
- A Network of Sputum MicroRNAs Is Associated with Neutrophilic Airway Inflammation in Asthma.American journal of respiratory and critical care medicine · 2020Article
- YKL-40 mediates airway remodeling in asthma via activating FAK and MAPK signaling pathway.Cell cycle (Georgetown, Tex.) · 2020Article
- Challenges of Clustering Multimodal Clinical Data: Review of Applications in Asthma Subtyping.JMIR medical informatics · 2020Review
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15 authors at 4 institutions in 1 country.
Funding
Abstract
The chitinase-like protein YKL-40 mediates airway inflammation and serum levels are associated with asthma severity. However, asthma phenotypes associated with YKL-40 levels have not been precisely defined.We conducted an unsupervised cluster analysis of asthma patients treated at the Yale Center for Asthma and Airways Disease (n=156) to identify subgroups according to YKL-40 level. The resulting YKL-40 clusters were cross-validated in cohorts from the Severe Asthma Research Programme (n=167) and the New York University/Bellevue Asthma Repository (n=341). A sputum transcriptome analysis revealed molecular pathways associated with YKL-40 subgroups.Four YKL-40 clusters (C1-C4) were identified. C3 and C4 had high serum YKL-40 levels compared with C1 and C2. C3 was associated with earlier onset and longer duration of disease, severe airflow obstruction, and near-fatal asthma exacerbations. C4 had the highest serum YKL-40 levels, adult onset and less airflow obstruction, but frequent exacerbations. An airway transcriptome analysis in C3 and C4 showed activation of non-type 2 inflammatory pathways.Elevated serum YKL-40 levels were associated with two distinct clinical asthma phenotypes: one with irreversible airway obstruction and another with severe exacerbations. The YKL-40 clusters are potentially useful for identification of individuals with severe or exacerbation-prone asthma.
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