Evidence map›Paper›PMID 29025876›Full record

ArticleThe Journal of biological chemistry2017

Mevalonate 5-diphosphate mediates ATP binding to the mevalonate diphosphate decarboxylase from the bacterial pathogen

Chun-Liang Chen, James C Mermoud, Lake N Paul, Calvin Nicklaus Steussy, Cynthia V Stauffacher

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Gut Microbiome in Chronic Coronary Syndrome Patients.Journal of clinical medicine · 2021
    Article
  3. Open life sciences · 2021
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chun-Liang ChenFrom the Department of Biological Sciences and.
James C MermoudFrom the Department of Biological Sciences and.
Lake N Paulthe Biophysical Analysis Laboratory, Bindley Bioscience Center, Purdue University, West Lafayette, Indiana 47906.
Calvin Nicklaus SteussyFrom the Department of Biological Sciences and.
Cynthia V StauffacherFrom the Department of Biological Sciences and cstauffa@purdue.edu.
Purdue University West Lafayette · US

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI John Tesmer · 1985 to 2026
$43.4M
NCI NIH HHS P30 CA023168
6 · The paper itself

Abstract

The mevalonate pathway produces isopentenyl diphosphate (IPP), a building block for polyisoprenoid synthesis, and is a crucial pathway for growth of the human bacterial pathogen

Indexed as

Adenosine TriphosphateAmino Acid SequenceBacterial ProteinsBinding SitesCarboxy-LyasesCrystallography, X-RayEnterococcus faecalisHemiterpenesKineticsMevalonic AcidOrganophosphorus CompoundsSubstrate Specificity5-diphosphomevalonic acidAdenosine TriphosphateBacterial ProteinsCarboxy-LyasesHemiterpenesisopentenyl pyrophosphateMevalonic AcidOrganophosphorus Compoundspyrophosphomevalonate decarboxylasecrystal structuredecarboxylasedrug resistanceEnterococcusenzyme kineticsenzyme mechanismisothermal titration calorimetry (ITC)mevalonate pathway

Identifiers

PMID29025876
PMCPMC5766736
OpenAlexW2761107667

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.