ArticleBMJ open2017
Investigating
Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Distinct early cellular kinetics in participants protected against colonization upon Bordetella pertussis challenge.The Journal of clinical investigation · 2023Trial
- Controlled Human Infection With Bordetella pertussis Induces Asymptomatic, Immunizing Colonization.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Trial
- Alternative approaches to phase III clinical trials for vaccine efficacy and licensure: the role of real-world evidence - a meeting report.Biologicals : journal of the International Association of Biological Standardization · 2026Article
- Post-exposure booster vaccination recalls vaccine-induced memory and accelerates Bordetella pertussis clearance in murine lungs and trachea.Scientific reports · 2026Article
- Development of High-Throughput Serum Bactericidal Assays forVaccines · 2026Article
- Th1 polarization in Bordetella pertussis vaccine responses is maintained through a positive feedback loop.Nature communications · 2025Article
- Controlled human malaria infection: overview and potential application in the evaluation of transmission-blocking interventions in malaria-endemic areas.Malaria journal · 2025Review
- Human challenge models for vaccine development-strengths, limitations, and expansion into endemic settings: a HIC-Vac meeting report.Immunotherapy advances · 2025Review
- An oropharyngeal gonorrhoea controlled human infection model: a provisional protocol using a novelWellcome open research · 2025Article
- Th1 polarization inbioRxiv : the preprint server for biology · 2024Article
- Development of an algorithm for finding pertussis episodes in a population-based electronic health record database.Human vaccines & immunotherapeutics · 2023Article
- Prior exposure to B. pertussis shapes the mucosal antibody response to acellular pertussis booster vaccination.Nature communications · 2022Article
- Controlled Human Infection Models To Accelerate Vaccine Development.Clinical microbiology reviews · 2022Review
- BCG-induced trained immunity enhances acellular pertussis vaccination responses in an explorative randomized clinical trial.NPJ vaccines · 2022Article
- Age and Primary Vaccination Background Influence the Plasma Cell Response to Pertussis Booster Vaccination.Vaccines · 2022Article
- Intranasal inoculation withCurrent research in microbial sciences · 2021Article
- Vaccine-Induced Cellular Immunity againstVaccines · 2021Review
- Highly Sensitive Flow Cytometry Allows Monitoring of Changes in Circulating Immune Cells in Blood After Tdap Booster Vaccination.Frontiers in immunology · 2021Article
- Review
- Adherence and Concordance of Influenza and Pertussis Vaccination Coverage in Pregnant Women in Spain.International journal of environmental research and public health · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
introductionWe summarise an ethically approved protocol for the development of an experimental human challenge colonisation model. Globally METHODS AND ANALYSIS: A controlled human colonisation model will be developed over two phases. In phase A, a low dose of the inoculum will be given intranasally to healthy participants. This dose will be escalated or de-escalated until colonisation is achieved in approximately 70% (95% CI 47% to 93%) of the exposed volunteers without causing disease. The colonisation period, shedding and exploratory immunology will be assessed during a 17-day inpatient stay and follow-up over 1 year. The dose of inoculum that achieves 70% colonisation will then be confirmed in phase B, comparing healthy participants exposed to ETHICS AND DISSEMINATION: This study has been approved by the ethical committee reference: 17/SC/0006, 24 February 2017. Findings will be published in peer-reviewed open access journals as soon as possible.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.