Evidence map›Paper›PMID 29025768›Full record

ArticleCirculation. Arrhythmia and electrophysiology2017

Action Potential Shortening and Impairment of Cardiac Function by Ablation of

Padmini Sirish, Hannah A Ledford, Valeriy Timofeyev, Phung N Thai, Lu Ren, Hyo Jeong Kim, Seojin Park, Jeong Han Lee, Gu Dai, Maryam Moshref and 10 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
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  11. Sex-Specific Alterations in Cardiac DNA Methylation in Adult Mice by Perinatal Lead Exposure.International journal of environmental research and public health · 2021
    Article
  12. Alterations in the CaExploration of targeted anti-tumor therapy · 2021
    Article
  13. Article
  14. Review
  15. Review
4 · The record

Corrections and comments

  • Commented on by
    Cl2017
5 · Who and what money

Authors and funding

20 authors at 1 institution in 1 country.

Padmini SirishFrom the Division of Cardiovascular Medicine, Department of Internal Medicine (P.S., H.A.L., V.T., P.N.T., L.R., S.P., G.D., M.M., C.-R.S., W.C.C., M.V.T., N.C., Y.C.-I., X.-D.Z.), Center for Neuroscience (H.J.K.), Department of Pharmacology (Z.J., R.S., L.T.I., N.C., Y.C.-I.) and Department of Biomedical Engineering (R.S., Y.C.-I.), University of California, Davis; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (M.V.T., N.C., X.-D.Z.).
Hannah A LedfordFrom the Division of Cardiovascular Medicine, Department of Internal Medicine (P.S., H.A.L., V.T., P.N.T., L.R., S.P., G.D., M.M., C.-R.S., W.C.C., M.V.T., N.C., Y.C.-I., X.-D.Z.), Center for Neuroscience (H.J.K.), Department of Pharmacology (Z.J., R.S., L.T.I., N.C., Y.C.-I.) and Department of Biomedical Engineering (R.S., Y.C.-I.), University of California, Davis; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (M.V.T., N.C., X.-D.Z.).
Valeriy TimofeyevFrom the Division of Cardiovascular Medicine, Department of Internal Medicine (P.S., H.A.L., V.T., P.N.T., L.R., S.P., G.D., M.M., C.-R.S., W.C.C., M.V.T., N.C., Y.C.-I., X.-D.Z.), Center for Neuroscience (H.J.K.), Department of Pharmacology (Z.J., R.S., L.T.I., N.C., Y.C.-I.) and Department of Biomedical Engineering (R.S., Y.C.-I.), University of California, Davis; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (M.V.T., N.C., X.-D.Z.).
Phung N ThaiFrom the Division of Cardiovascular Medicine, Department of Internal Medicine (P.S., H.A.L., V.T., P.N.T., L.R., S.P., G.D., M.M., C.-R.S., W.C.C., M.V.T., N.C., Y.C.-I., X.-D.Z.), Center for Neuroscience (H.J.K.), Department of Pharmacology (Z.J., R.S., L.T.I., N.C., Y.C.-I.) and Department of Biomedical Engineering (R.S., Y.C.-I.), University of California, Davis; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (M.V.T., N.C., X.-D.Z.).
Lu RenFrom the Division of Cardiovascular Medicine, Department of Internal Medicine (P.S., H.A.L., V.T., P.N.T., L.R., S.P., G.D., M.M., C.-R.S., W.C.C., M.V.T., N.C., Y.C.-I., X.-D.Z.), Center for Neuroscience (H.J.K.), Department of Pharmacology (Z.J., R.S., L.T.I., N.C., Y.C.-I.) and Department of Biomedical Engineering (R.S., Y.C.-I.), University of California, Davis; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (M.V.T., N.C., X.-D.Z.).
Hyo Jeong KimFrom the Division of Cardiovascular Medicine, Department of Internal Medicine (P.S., H.A.L., V.T., P.N.T., L.R., S.P., G.D., M.M., C.-R.S., W.C.C., M.V.T., N.C., Y.C.-I., X.-D.Z.), Center for Neuroscience (H.J.K.), Department of Pharmacology (Z.J., R.S., L.T.I., N.C., Y.C.-I.) and Department of Biomedical Engineering (R.S., Y.C.-I.), University of California, Davis; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (M.V.T., N.C., X.-D.Z.).
Seojin ParkFrom the Division of Cardiovascular Medicine, Department of Internal Medicine (P.S., H.A.L., V.T., P.N.T., L.R., S.P., G.D., M.M., C.-R.S., W.C.C., M.V.T., N.C., Y.C.-I., X.-D.Z.), Center for Neuroscience (H.J.K.), Department of Pharmacology (Z.J., R.S., L.T.I., N.C., Y.C.-I.) and Department of Biomedical Engineering (R.S., Y.C.-I.), University of California, Davis; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (M.V.T., N.C., X.-D.Z.).
Jeong Han LeeFrom the Division of Cardiovascular Medicine, Department of Internal Medicine (P.S., H.A.L., V.T., P.N.T., L.R., S.P., G.D., M.M., C.-R.S., W.C.C., M.V.T., N.C., Y.C.-I., X.-D.Z.), Center for Neuroscience (H.J.K.), Department of Pharmacology (Z.J., R.S., L.T.I., N.C., Y.C.-I.) and Department of Biomedical Engineering (R.S., Y.C.-I.), University of California, Davis; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (M.V.T., N.C., X.-D.Z.).
Gu DaiFrom the Division of Cardiovascular Medicine, Department of Internal Medicine (P.S., H.A.L., V.T., P.N.T., L.R., S.P., G.D., M.M., C.-R.S., W.C.C., M.V.T., N.C., Y.C.-I., X.-D.Z.), Center for Neuroscience (H.J.K.), Department of Pharmacology (Z.J., R.S., L.T.I., N.C., Y.C.-I.) and Department of Biomedical Engineering (R.S., Y.C.-I.), University of California, Davis; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (M.V.T., N.C., X.-D.Z.).
Maryam MoshrefFrom the Division of Cardiovascular Medicine, Department of Internal Medicine (P.S., H.A.L., V.T., P.N.T., L.R., S.P., G.D., M.M., C.-R.S., W.C.C., M.V.T., N.C., Y.C.-I., X.-D.Z.), Center for Neuroscience (H.J.K.), Department of Pharmacology (Z.J., R.S., L.T.I., N.C., Y.C.-I.) and Department of Biomedical Engineering (R.S., Y.C.-I.), University of California, Davis; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (M.V.T., N.C., X.-D.Z.).
Choong-Ryoul SihnFrom the Division of Cardiovascular Medicine, Department of Internal Medicine (P.S., H.A.L., V.T., P.N.T., L.R., S.P., G.D., M.M., C.-R.S., W.C.C., M.V.T., N.C., Y.C.-I., X.-D.Z.), Center for Neuroscience (H.J.K.), Department of Pharmacology (Z.J., R.S., L.T.I., N.C., Y.C.-I.) and Department of Biomedical Engineering (R.S., Y.C.-I.), University of California, Davis; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (M.V.T., N.C., X.-D.Z.).
Wei Chun ChenFrom the Division of Cardiovascular Medicine, Department of Internal Medicine (P.S., H.A.L., V.T., P.N.T., L.R., S.P., G.D., M.M., C.-R.S., W.C.C., M.V.T., N.C., Y.C.-I., X.-D.Z.), Center for Neuroscience (H.J.K.), Department of Pharmacology (Z.J., R.S., L.T.I., N.C., Y.C.-I.) and Department of Biomedical Engineering (R.S., Y.C.-I.), University of California, Davis; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (M.V.T., N.C., X.-D.Z.).
Maria Valeryevna TimofeyevaFrom the Division of Cardiovascular Medicine, Department of Internal Medicine (P.S., H.A.L., V.T., P.N.T., L.R., S.P., G.D., M.M., C.-R.S., W.C.C., M.V.T., N.C., Y.C.-I., X.-D.Z.), Center for Neuroscience (H.J.K.), Department of Pharmacology (Z.J., R.S., L.T.I., N.C., Y.C.-I.) and Department of Biomedical Engineering (R.S., Y.C.-I.), University of California, Davis; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (M.V.T., N.C., X.-D.Z.).
Zhong JianFrom the Division of Cardiovascular Medicine, Department of Internal Medicine (P.S., H.A.L., V.T., P.N.T., L.R., S.P., G.D., M.M., C.-R.S., W.C.C., M.V.T., N.C., Y.C.-I., X.-D.Z.), Center for Neuroscience (H.J.K.), Department of Pharmacology (Z.J., R.S., L.T.I., N.C., Y.C.-I.) and Department of Biomedical Engineering (R.S., Y.C.-I.), University of California, Davis; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (M.V.T., N.C., X.-D.Z.).
Rafael ShimkunasFrom the Division of Cardiovascular Medicine, Department of Internal Medicine (P.S., H.A.L., V.T., P.N.T., L.R., S.P., G.D., M.M., C.-R.S., W.C.C., M.V.T., N.C., Y.C.-I., X.-D.Z.), Center for Neuroscience (H.J.K.), Department of Pharmacology (Z.J., R.S., L.T.I., N.C., Y.C.-I.) and Department of Biomedical Engineering (R.S., Y.C.-I.), University of California, Davis; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (M.V.T., N.C., X.-D.Z.).
Leighton T IzuFrom the Division of Cardiovascular Medicine, Department of Internal Medicine (P.S., H.A.L., V.T., P.N.T., L.R., S.P., G.D., M.M., C.-R.S., W.C.C., M.V.T., N.C., Y.C.-I., X.-D.Z.), Center for Neuroscience (H.J.K.), Department of Pharmacology (Z.J., R.S., L.T.I., N.C., Y.C.-I.) and Department of Biomedical Engineering (R.S., Y.C.-I.), University of California, Davis; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (M.V.T., N.C., X.-D.Z.).
Nipavan ChiamvimonvatFrom the Division of Cardiovascular Medicine, Department of Internal Medicine (P.S., H.A.L., V.T., P.N.T., L.R., S.P., G.D., M.M., C.-R.S., W.C.C., M.V.T., N.C., Y.C.-I., X.-D.Z.), Center for Neuroscience (H.J.K.), Department of Pharmacology (Z.J., R.S., L.T.I., N.C., Y.C.-I.) and Department of Biomedical Engineering (R.S., Y.C.-I.), University of California, Davis; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (M.V.T., N.C., X.-D.Z.).
Ye Chen-IzuFrom the Division of Cardiovascular Medicine, Department of Internal Medicine (P.S., H.A.L., V.T., P.N.T., L.R., S.P., G.D., M.M., C.-R.S., W.C.C., M.V.T., N.C., Y.C.-I., X.-D.Z.), Center for Neuroscience (H.J.K.), Department of Pharmacology (Z.J., R.S., L.T.I., N.C., Y.C.-I.) and Department of Biomedical Engineering (R.S., Y.C.-I.), University of California, Davis; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (M.V.T., N.C., X.-D.Z.).
Ebenezer N YamoahFrom the Division of Cardiovascular Medicine, Department of Internal Medicine (P.S., H.A.L., V.T., P.N.T., L.R., S.P., G.D., M.M., C.-R.S., W.C.C., M.V.T., N.C., Y.C.-I., X.-D.Z.), Center for Neuroscience (H.J.K.), Department of Pharmacology (Z.J., R.S., L.T.I., N.C., Y.C.-I.) and Department of Biomedical Engineering (R.S., Y.C.-I.), University of California, Davis; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (M.V.T., N.C., X.-D.Z.).
Xiao-Dong ZhangFrom the Division of Cardiovascular Medicine, Department of Internal Medicine (P.S., H.A.L., V.T., P.N.T., L.R., S.P., G.D., M.M., C.-R.S., W.C.C., M.V.T., N.C., Y.C.-I., X.-D.Z.), Center for Neuroscience (H.J.K.), Department of Pharmacology (Z.J., R.S., L.T.I., N.C., Y.C.-I.) and Department of Biomedical Engineering (R.S., Y.C.-I.), University of California, Davis; Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno (J.H.L., E.N.Y.); and Department of Veterans Affairs, Northern California Health Care System, Mather (M.V.T., N.C., X.-D.Z.). xdzhang@ucdavis.edu.
University of Nevada, Reno · US

Funding

Workshop on Environmental Technology Transfer and EntrepreneurshipP42ES004699 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1987 to 2021
$50.1M
Structural Analyses CoreP01AG051443 · NIA · UNIVERSITY OF NEVADA RENO · PI RUBIO-VALERO, MARIA-EULALIA · 2016 to 2025
$15.5M
Functional Interactions of Cardiac Ion ChannelsR01HL085844 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN · 2007 to 2025
$7.3M
Training Program In Basic & Translational Cardiovascular ScienceT32HL086350 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Martin Cadeiras, David A. Liem · 2008 to 2026
$7.1M
Translational Study of Cardiac DysfunctionR01HL085727 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN, SIRISH, PADMINI · 2008 to 2022
$5.7M
Inner ear ion channels in healthy and diseased conditionsR01DC016099 · NIDCD · UNIVERSITY OF NEVADA RENO · PI EBENEZER N YAMOAH · 2017 to 2026
$4.7M
Potassium Homeostasis in the Inner EarR01DC007592 · NIDCD · UNIVERSITY OF NEVADA RENO · PI YAMOAH, EBENEZER N · 2005 to 2014
$4.5M
Decoding the enigma of cardiac amplificationR01HL137228 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN · 2017 to 2020
$2.2M
Calcium-dependent functions in Hair Cells and Spiral Ganglion NeuronsR01DC015135 · NIDCD · UNIVERSITY OF NEVADA RENO · PI GRATTON, MICHAEL ANNE NMI, YAMOAH, EBENEZER N · 2016 to 2020
$2.1M
Regulation of hair cell functionsR01DC015252 · NIDCD · UNIVERSITY OF NEVADA RENO · PI YAMOAH, EBENEZER N · 2017 to 2021
$2.1M
Novel Cell-in-Gel System for Mechanotransduction Study at the Single Cell LevelR01HL123526 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN-IZU, YE · 2015 to 2018
$1.8M
FUNCTIONAL PROPERTIES OF CA PUMPS IN HAIR CELLR01DC004215 · NIDCD · UNIVERSITY OF CINCINNATI · PI YAMOAH, EBENEZER N. · 1999 to 2003
$1.0M
BLRD VA I01 BX000576CSRD VA I01 CX001490NHLBI NIH HHS F31 HL136120NHLBI NIH HHS R01 HL085727NHLBI NIH HHS R01 HL085844NHLBI NIH HHS R01 HL123526NHLBI NIH HHS R01 HL137228NHLBI NIH HHS T32 HL086350NIA NIH HHS P01 AG051443NIDCD NIH HHS R01 DC004215NIDCD NIH HHS R01 DC007592NIDCD NIH HHS R01 DC015135NIDCD NIH HHS R01 DC015252NIDCD NIH HHS R01 DC016099NIEHS NIH HHS P42 ES004699NIH HHS S10 OD010389
6 · The paper itself

Abstract

backgroundIntracellular pH (pH METHODS AND

resultsTo test the mechanistic role of Slc26a6 in the heart, we took advantage of

conclusionsOur study provides mechanistic insights into Slc26a6, a unique cardiac electrogenic Cl

Indexed as

Action PotentialsExcitation Contraction CouplingHeart RateMyocardial ContractionAnimalsAntiportersBradycardiaCHO CellsCricetulusGenotypeHydrogen-Ion ConcentrationKineticsMembrane Transport ProteinsMice, 129 StrainMice, KnockoutMyocytes, CardiacAntiportersMembrane Transport ProteinsSLC26A6 protein, humanSlc26a6 protein, mouseSulfate Transportersaction potentialbradycardiachloride-bicarbonate antiportersmyocardial contraction

Identifiers

PMID29025768
PMCPMC5662469
OpenAlexW2760875748

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.