Evidence map›Paper›PMID 29025746›Full record

ArticleJournal of the American Heart Association2017

Clinical Prediction Model for Time in Therapeutic Range While on Warfarin in Newly Diagnosed Atrial Fibrillation.

Brent A Williams, Michael A Evans, Ashley M Honushefsky, Peter B Berger

Open access · goldAbstract readValidation Study
In one paragraph

Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. SAMe-TTAmerican journal of cardiovascular drugs : drugs, devices, and other interventions · 2024
    Pooled it
  2. Semi-empirical anticoagulation model (SAM): INR monitoring during Warfarin therapy.Journal of pharmacokinetics and pharmacodynamics · 2022
    Article
  3. Article
  4. Article
  5. Article
  6. The SAMe-TTJournal of clinical medicine · 2019
    Article
  7. Article
  8. Review
  9. Article
  10. Factors Affecting the Time in Therapeutic Range of Warfarin Anticoagulation Therapy in Patients with Atrial Fibrillation.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Brent A WilliamsGeisinger Health System, Danville, PA bawilliams2@geisinger.edu.
Michael A EvansGeisinger Health System, Danville, PA.
Ashley M HonushefskyGeisinger Health System, Danville, PA.
Peter B BergerNew York, NY.
Geisinger Health System · USNew York Proton Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThough warfarin has historically been the primary oral anticoagulant for stroke prevention in newly diagnosed atrial fibrillation (AF), several new direct oral anticoagulants may be preferred when anticoagulation control with warfarin is expected to be poor. This study developed a prediction model for time in therapeutic range (TTR) among newly diagnosed AF patients on newly initiated warfarin as a tool to assist decision making between warfarin and direct oral anticoagulants. METHODS AND

resultsThis electronic medical record-based, retrospective study included newly diagnosed, nonvalvular AF patients with no recent warfarin exposure receiving primary care services through a large healthcare system in rural Pennsylvania. TTR was estimated as the percentage of time international normalized ratio measurements were between 2.0 and 3.0 during the first year following warfarin initiation. Candidate predictors of TTR were chosen from data elements collected during usual clinical care. A TTR prediction model was developed and temporally validated and its predictive performance was compared with the SAMe-TT

conclusionsThe proposed prediction model may assist decision making on the proper mode of oral anticoagulant among newly diagnosed AF patients. However, predicting TTR on warfarin remains challenging.

Indexed as

Decision Support TechniquesInternational Normalized RatioAdministration, OralAgedAged, 80 and overAnticoagulantsAtrial FibrillationBlood CoagulationDrug MonitoringElectronic Health RecordsFemaleHumansMaleMiddle AgedPennsylvaniaPredictive Value of TestsAnticoagulantsWarfarinanticoagulationatrial fibrillationstroke

Identifiers

PMID29025746
PMCPMC5721868
OpenAlexW2762510272

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.