Evidence map›Paper›PMID 29025732›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2018

Rack1 maintains intestinal homeostasis by protecting the integrity of the epithelial barrier.

Zhuan-Fen Cheng, Christine A Cartwright

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Zhuan-Fen ChengDepartment of Medicine, Stanford University , Stanford, California.
Christine A CartwrightDepartment of Medicine, Stanford University , Stanford, California.
Stanford University · US

Funding

Proteomics/GenomicsP30DK056339 · NIDDK · STANFORD UNIVERSITY · PI GREENBERG, HARRY BERNARD · 2001 to 2010
$10.4M
INTESTINAL CELL GROWTH CONTROL: ROLE OF TYROSINE KINASESR01DK043743 · NIDDK · STANFORD UNIVERSITY · PI CARTWRIGHT, CHRISTINE ANN · 1996 to 2015
$4.3M
NIDDK NIH HHS P30 DK056339NIDDK NIH HHS R01 DK043743
6 · The paper itself

Abstract

Previously, we generated mouse models of Rack1 deficiency to identify key functions for Rack1 in regulating growth of intestinal epithelia: suppressing crypt cell proliferation and regeneration, promoting differentiation and apoptosis, and repressing development of neoplasia. However, other than low body weight, we did not detect an overt phenotype in mice constitutively deleted of Rack1 in intestinal epithelia ( vil-Cre: Rack1

Indexed as

Intestinal AbsorptionAnimalsDiarrheaEnterocolitisEpithelial CellsGastrointestinal HemorrhageGenetic Predisposition to DiseaseHomeostasisIntestinal MucosaMice, KnockoutPermeabilityPhenotypeReceptors for Activated C KinaseSignal TransductionWeight LossRACK1 protein, mouseReceptors for Activated C Kinaseenterocolitisgene knockoutintestinal epitheliumRack1

Identifiers

PMID29025732
PMCPMC5866421
OpenAlexW2763906443

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.