Evidence map›Paper›PMID 29025708›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2017

Intermuscular Adipose Tissue and Subclinical Coronary Artery Calcification in Midlife: The CARDIA Study (Coronary Artery Risk Development in Young Adults).

James G Terry, Christina M Shay, Pamela J Schreiner, David R Jacobs, Otto A Sanchez, Jared P Reis, David C Goff, Samuel S Gidding, Lyn M Steffen, John Jeffrey Carr

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 63 citations in OpenAlex.

  1. Observational
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  6. Plasma proteomic analysis of intermuscular fat links muscle integrity with processing speed in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

James G TerryFrom the Department of Radiology, Vanderbilt University School of Medicine, Nashville, TN (J.G.T., J.J.C.); American Heart Association, Dallas, TX (C.M.S.); School of Public Health (P.J.S., D.R.J., L.M.S.) and Department of Medicine (O.A.S.), University of Minnesota, Minneapolis; Department of Internal Medicine (O.A.S.); National Institutes of Health, Bethesda, MD (J.P.R., D.C.G.); and A.I. DuPont Hospital of Children, Wilmington, DE (S.S.G.). james.g.terry@vanderbilt.edu j.jeffrey.carr@vanderbilt.edu.
Christina M ShayFrom the Department of Radiology, Vanderbilt University School of Medicine, Nashville, TN (J.G.T., J.J.C.); American Heart Association, Dallas, TX (C.M.S.); School of Public Health (P.J.S., D.R.J., L.M.S.) and Department of Medicine (O.A.S.), University of Minnesota, Minneapolis; Department of Internal Medicine (O.A.S.); National Institutes of Health, Bethesda, MD (J.P.R., D.C.G.); and A.I. DuPont Hospital of Children, Wilmington, DE (S.S.G.).
Pamela J SchreinerFrom the Department of Radiology, Vanderbilt University School of Medicine, Nashville, TN (J.G.T., J.J.C.); American Heart Association, Dallas, TX (C.M.S.); School of Public Health (P.J.S., D.R.J., L.M.S.) and Department of Medicine (O.A.S.), University of Minnesota, Minneapolis; Department of Internal Medicine (O.A.S.); National Institutes of Health, Bethesda, MD (J.P.R., D.C.G.); and A.I. DuPont Hospital of Children, Wilmington, DE (S.S.G.).
David R JacobsFrom the Department of Radiology, Vanderbilt University School of Medicine, Nashville, TN (J.G.T., J.J.C.); American Heart Association, Dallas, TX (C.M.S.); School of Public Health (P.J.S., D.R.J., L.M.S.) and Department of Medicine (O.A.S.), University of Minnesota, Minneapolis; Department of Internal Medicine (O.A.S.); National Institutes of Health, Bethesda, MD (J.P.R., D.C.G.); and A.I. DuPont Hospital of Children, Wilmington, DE (S.S.G.).
Otto A SanchezFrom the Department of Radiology, Vanderbilt University School of Medicine, Nashville, TN (J.G.T., J.J.C.); American Heart Association, Dallas, TX (C.M.S.); School of Public Health (P.J.S., D.R.J., L.M.S.) and Department of Medicine (O.A.S.), University of Minnesota, Minneapolis; Department of Internal Medicine (O.A.S.); National Institutes of Health, Bethesda, MD (J.P.R., D.C.G.); and A.I. DuPont Hospital of Children, Wilmington, DE (S.S.G.).
Jared P ReisFrom the Department of Radiology, Vanderbilt University School of Medicine, Nashville, TN (J.G.T., J.J.C.); American Heart Association, Dallas, TX (C.M.S.); School of Public Health (P.J.S., D.R.J., L.M.S.) and Department of Medicine (O.A.S.), University of Minnesota, Minneapolis; Department of Internal Medicine (O.A.S.); National Institutes of Health, Bethesda, MD (J.P.R., D.C.G.); and A.I. DuPont Hospital of Children, Wilmington, DE (S.S.G.).
David C GoffFrom the Department of Radiology, Vanderbilt University School of Medicine, Nashville, TN (J.G.T., J.J.C.); American Heart Association, Dallas, TX (C.M.S.); School of Public Health (P.J.S., D.R.J., L.M.S.) and Department of Medicine (O.A.S.), University of Minnesota, Minneapolis; Department of Internal Medicine (O.A.S.); National Institutes of Health, Bethesda, MD (J.P.R., D.C.G.); and A.I. DuPont Hospital of Children, Wilmington, DE (S.S.G.).
Samuel S GiddingFrom the Department of Radiology, Vanderbilt University School of Medicine, Nashville, TN (J.G.T., J.J.C.); American Heart Association, Dallas, TX (C.M.S.); School of Public Health (P.J.S., D.R.J., L.M.S.) and Department of Medicine (O.A.S.), University of Minnesota, Minneapolis; Department of Internal Medicine (O.A.S.); National Institutes of Health, Bethesda, MD (J.P.R., D.C.G.); and A.I. DuPont Hospital of Children, Wilmington, DE (S.S.G.).
Lyn M SteffenFrom the Department of Radiology, Vanderbilt University School of Medicine, Nashville, TN (J.G.T., J.J.C.); American Heart Association, Dallas, TX (C.M.S.); School of Public Health (P.J.S., D.R.J., L.M.S.) and Department of Medicine (O.A.S.), University of Minnesota, Minneapolis; Department of Internal Medicine (O.A.S.); National Institutes of Health, Bethesda, MD (J.P.R., D.C.G.); and A.I. DuPont Hospital of Children, Wilmington, DE (S.S.G.).
John Jeffrey CarrFrom the Department of Radiology, Vanderbilt University School of Medicine, Nashville, TN (J.G.T., J.J.C.); American Heart Association, Dallas, TX (C.M.S.); School of Public Health (P.J.S., D.R.J., L.M.S.) and Department of Medicine (O.A.S.), University of Minnesota, Minneapolis; Department of Internal Medicine (O.A.S.); National Institutes of Health, Bethesda, MD (J.P.R., D.C.G.); and A.I. DuPont Hospital of Children, Wilmington, DE (S.S.G.). james.g.terry@vanderbilt.edu j.jeffrey.carr@vanderbilt.edu.
American Heart Association · USNational Institutes of Health · USJacobs (United States) · USVanderbilt University · US

Funding

Longitudinal Changes in Pericardial Adiposity and Subclinical AtherosclerosisR01HL098445 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CARR, JOHN JEFFREY · 2010 to 2013
$4.6M
NHLBI NIH HHS HHSN268200900041CNHLBI NIH HHS HHSN268201300025CNHLBI NIH HHS HHSN268201300026CNHLBI NIH HHS HHSN268201300027CNHLBI NIH HHS HHSN268201300028CNHLBI NIH HHS HHSN268201300029CNHLBI NIH HHS R01 HL098445
6 · The paper itself

Abstract

objectiveExcess deposition of fat within and around vital organs and nonadipose tissues is hypothesized to contribute to cardiovascular disease (CVD) risk. We evaluated the association of abdominal intermuscular adipose tissue (IMAT) volume with coronary artery calcification in the CARDIA study (Coronary Artery Risk Development in Young Adults) participants. APPROACH AND

resultsWe measured IMAT in the abdominal muscles, visceral adipose tissue and pericardial adipose tissue, and coronary artery calcification using computed tomography in 3051 CARDIA participants (56% women) at the CARDIA year 25 examination (2010-2011). Mean IMAT volume and mean IMAT/total muscle volume (IMAT normalized for muscle size) were calculated in a 10-mm block of slices centered at L3-L4. Multivariable analyses included potential confounders and traditional cardiovascular disease risk factors. Compared with the lowest quartile, the upper quartile of abdominal IMAT volume was associated with higher coronary artery calcification prevalence (odds ratio [95% confidence interval], 1.6 [1.2-2.1]) after adjusting for cardiovascular disease risk factors. Results were similar for highest versus lowest quartile of IMAT normalized to total muscle volume (odds ratio [95% confidence interval], 1.5 [1.1-2.0]). Significant associations of higher IMAT and normalized IMAT with coronary artery calcification prevalence persisted when body mass index, visceral adipose tissue, or pericardial adipose tissue were added to the models.

conclusionsIn a large, community-based, cross-sectional study, we found that higher abdominal skeletal muscle adipose tissue volume was associated with subclinical atherosclerosis independent of traditional cardiovascular disease risk factors and other adipose depots.

Indexed as

AdiposityAbdominal MusclesAdolescentAdultAge FactorsAsymptomatic DiseasesComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCross-Sectional StudiesFemaleHumansIntra-Abdominal FatLogistic ModelsMaleMiddle Agedadipose tissuebody mass indexmuscleprevalencerisk factorsvascular calcification

Identifiers

PMID29025708
PMCPMC5699947
OpenAlexW2764310341

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.