ArticleArteriosclerosis, thrombosis, and vascular biology2018
Proatherogenic Flow Increases Endothelial Stiffness via Enhanced CD36-Mediated Uptake of Oxidized Low-Density Lipoproteins.
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Article in Arteriosclerosis, thrombosis, and vascular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Identification and analysis of oxidative stress-related genes associated with the occurrence and development of diabetic retinopathy.Scientific reports · 2026Article
- Endothelial Stiffening Induced by CD36-Mediated Lipid Uptake Leads to Endothelial Barrier Disruption and Contributes to Atherosclerotic Lesions.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Post-translational modifications in kidney diseases and associated cardiovascular risk.Nature reviews. Nephrology · 2024Review
- Effectiveness of Regular Aerobic Exercise in Improving Vascular Stiffness in Elderly Korean Women.Journal of clinical medicine · 2023Article
- Caveolin-1 is a primary determinant of endothelial stiffening associated with dyslipidemia, disturbed flow, and ageing.Scientific reports · 2022Article
- AFM-based nanoindentation indicates an impaired cortical stiffness in the AAV-PCSK9Pflugers Archiv : European journal of physiology · 2022Article
- Differential effects of obesity on visceral versus subcutaneous adipose arteries: role of shear-activated Kir2.1 and alterations to the glycocalyx.American journal of physiology. Heart and circulatory physiology · 2022Article
- Paradigms of endothelial stiffening in cardiovascular disease and vascular aging.Frontiers in physiology · 2022Review
- Lipoproteins and fatty acids in chronic kidney disease: molecular and metabolic alterations.Nature reviews. Nephrology · 2021Review
- Single-cell RNA-seq reveals cellular heterogeneity of mouse carotid artery under disturbed flow.Cell death discovery · 2021Article
- CD36 Signaling in Diabetic Cardiomyopathy.Aging and disease · 2021Review
- The glycocalyx core protein Glypican 1 protects vessel wall endothelial cells from stiffness-mediated dysfunction and disease.Cardiovascular research · 2021Article
- Intravascular Crawling of Patrolling Monocytes: A Lèvy-Like Motility for Unique Search Functions?Frontiers in immunology · 2021Review
- Mechanical forces and metabolic changes cooperate to drive cellular memory and endothelial phenotypes.Current topics in membranes · 2021Review
- Impairment of Flow-Sensitive Inwardly Rectifying KArteriosclerosis, thrombosis, and vascular biology · 2020Article
- CD36 in Atherosclerosis: Pathophysiological Mechanisms and Therapeutic Implications.Current atherosclerosis reports · 2020Review
- Vascular Endothelial Cells and Innate Immunity.Arteriosclerosis, thrombosis, and vascular biology · 2020Review
- LDL induces cholesterol loading and inhibits endothelial proliferation and angiogenesis in Matrigels: correlation with impaired angiogenesis during wound healing.American journal of physiology. Cell physiology · 2020Article
- Mechanisms of endothelial stiffening in dyslipidemia and aging: Oxidized lipids and shear stress.Current topics in membranes · 2020Review
- Annual Report on Sex in Preclinical Studies:Arteriosclerosis, thrombosis, and vascular biology · 2020Review
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Authors and funding
19 authors at 1 institution in 1 country.
Elizabeth Le MasterFrom the Division of Pulmonary and Critical Care (E.L.M., C.Z., T.-P.S., I.S.F., I.L.), Division of Endocrinology (P.V.S.), Division of Hematology and Oncology, Department of Medicine (Y.S., Z.Q.), and Departments of Bioengineering (E.L.M., T.-P.S., C.N., T.C., D.T.E., J.L., M.C., I.L.), Pharmacology (Y.B., C.C., R.D.M., I.L.), and Anesthesiology (R.D.M.), University of Illinois at Chicago; Department of Medicine, University of Chicago, IL (R.-T.H., Y.F.); and Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO (E.B.).
Ru-Ting HuangFrom the Division of Pulmonary and Critical Care (E.L.M., C.Z., T.-P.S., I.S.F., I.L.), Division of Endocrinology (P.V.S.), Division of Hematology and Oncology, Department of Medicine (Y.S., Z.Q.), and Departments of Bioengineering (E.L.M., T.-P.S., C.N., T.C., D.T.E., J.L., M.C., I.L.), Pharmacology (Y.B., C.C., R.D.M., I.L.), and Anesthesiology (R.D.M.), University of Illinois at Chicago; Department of Medicine, University of Chicago, IL (R.-T.H., Y.F.); and Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO (E.B.).
Chongxu ZhangFrom the Division of Pulmonary and Critical Care (E.L.M., C.Z., T.-P.S., I.S.F., I.L.), Division of Endocrinology (P.V.S.), Division of Hematology and Oncology, Department of Medicine (Y.S., Z.Q.), and Departments of Bioengineering (E.L.M., T.-P.S., C.N., T.C., D.T.E., J.L., M.C., I.L.), Pharmacology (Y.B., C.C., R.D.M., I.L.), and Anesthesiology (R.D.M.), University of Illinois at Chicago; Department of Medicine, University of Chicago, IL (R.-T.H., Y.F.); and Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO (E.B.).
Yedida BogachkovFrom the Division of Pulmonary and Critical Care (E.L.M., C.Z., T.-P.S., I.S.F., I.L.), Division of Endocrinology (P.V.S.), Division of Hematology and Oncology, Department of Medicine (Y.S., Z.Q.), and Departments of Bioengineering (E.L.M., T.-P.S., C.N., T.C., D.T.E., J.L., M.C., I.L.), Pharmacology (Y.B., C.C., R.D.M., I.L.), and Anesthesiology (R.D.M.), University of Illinois at Chicago; Department of Medicine, University of Chicago, IL (R.-T.H., Y.F.); and Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO (E.B.).
Cassandre ColesFrom the Division of Pulmonary and Critical Care (E.L.M., C.Z., T.-P.S., I.S.F., I.L.), Division of Endocrinology (P.V.S.), Division of Hematology and Oncology, Department of Medicine (Y.S., Z.Q.), and Departments of Bioengineering (E.L.M., T.-P.S., C.N., T.C., D.T.E., J.L., M.C., I.L.), Pharmacology (Y.B., C.C., R.D.M., I.L.), and Anesthesiology (R.D.M.), University of Illinois at Chicago; Department of Medicine, University of Chicago, IL (R.-T.H., Y.F.); and Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO (E.B.).
Tzu-Pin ShentuFrom the Division of Pulmonary and Critical Care (E.L.M., C.Z., T.-P.S., I.S.F., I.L.), Division of Endocrinology (P.V.S.), Division of Hematology and Oncology, Department of Medicine (Y.S., Z.Q.), and Departments of Bioengineering (E.L.M., T.-P.S., C.N., T.C., D.T.E., J.L., M.C., I.L.), Pharmacology (Y.B., C.C., R.D.M., I.L.), and Anesthesiology (R.D.M.), University of Illinois at Chicago; Department of Medicine, University of Chicago, IL (R.-T.H., Y.F.); and Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO (E.B.).
Yue ShengFrom the Division of Pulmonary and Critical Care (E.L.M., C.Z., T.-P.S., I.S.F., I.L.), Division of Endocrinology (P.V.S.), Division of Hematology and Oncology, Department of Medicine (Y.S., Z.Q.), and Departments of Bioengineering (E.L.M., T.-P.S., C.N., T.C., D.T.E., J.L., M.C., I.L.), Pharmacology (Y.B., C.C., R.D.M., I.L.), and Anesthesiology (R.D.M.), University of Illinois at Chicago; Department of Medicine, University of Chicago, IL (R.-T.H., Y.F.); and Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO (E.B.).
Ibra S FancherFrom the Division of Pulmonary and Critical Care (E.L.M., C.Z., T.-P.S., I.S.F., I.L.), Division of Endocrinology (P.V.S.), Division of Hematology and Oncology, Department of Medicine (Y.S., Z.Q.), and Departments of Bioengineering (E.L.M., T.-P.S., C.N., T.C., D.T.E., J.L., M.C., I.L.), Pharmacology (Y.B., C.C., R.D.M., I.L.), and Anesthesiology (R.D.M.), University of Illinois at Chicago; Department of Medicine, University of Chicago, IL (R.-T.H., Y.F.); and Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO (E.B.).
Carlos NgFrom the Division of Pulmonary and Critical Care (E.L.M., C.Z., T.-P.S., I.S.F., I.L.), Division of Endocrinology (P.V.S.), Division of Hematology and Oncology, Department of Medicine (Y.S., Z.Q.), and Departments of Bioengineering (E.L.M., T.-P.S., C.N., T.C., D.T.E., J.L., M.C., I.L.), Pharmacology (Y.B., C.C., R.D.M., I.L.), and Anesthesiology (R.D.M.), University of Illinois at Chicago; Department of Medicine, University of Chicago, IL (R.-T.H., Y.F.); and Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO (E.B.).
Theodore ChristoforidisFrom the Division of Pulmonary and Critical Care (E.L.M., C.Z., T.-P.S., I.S.F., I.L.), Division of Endocrinology (P.V.S.), Division of Hematology and Oncology, Department of Medicine (Y.S., Z.Q.), and Departments of Bioengineering (E.L.M., T.-P.S., C.N., T.C., D.T.E., J.L., M.C., I.L.), Pharmacology (Y.B., C.C., R.D.M., I.L.), and Anesthesiology (R.D.M.), University of Illinois at Chicago; Department of Medicine, University of Chicago, IL (R.-T.H., Y.F.); and Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO (E.B.).
Pappasani V SubbaiahFrom the Division of Pulmonary and Critical Care (E.L.M., C.Z., T.-P.S., I.S.F., I.L.), Division of Endocrinology (P.V.S.), Division of Hematology and Oncology, Department of Medicine (Y.S., Z.Q.), and Departments of Bioengineering (E.L.M., T.-P.S., C.N., T.C., D.T.E., J.L., M.C., I.L.), Pharmacology (Y.B., C.C., R.D.M., I.L.), and Anesthesiology (R.D.M.), University of Illinois at Chicago; Department of Medicine, University of Chicago, IL (R.-T.H., Y.F.); and Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO (E.B.).
Evgeny BerdyshevFrom the Division of Pulmonary and Critical Care (E.L.M., C.Z., T.-P.S., I.S.F., I.L.), Division of Endocrinology (P.V.S.), Division of Hematology and Oncology, Department of Medicine (Y.S., Z.Q.), and Departments of Bioengineering (E.L.M., T.-P.S., C.N., T.C., D.T.E., J.L., M.C., I.L.), Pharmacology (Y.B., C.C., R.D.M., I.L.), and Anesthesiology (R.D.M.), University of Illinois at Chicago; Department of Medicine, University of Chicago, IL (R.-T.H., Y.F.); and Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO (E.B.).
Zhijian QainFrom the Division of Pulmonary and Critical Care (E.L.M., C.Z., T.-P.S., I.S.F., I.L.), Division of Endocrinology (P.V.S.), Division of Hematology and Oncology, Department of Medicine (Y.S., Z.Q.), and Departments of Bioengineering (E.L.M., T.-P.S., C.N., T.C., D.T.E., J.L., M.C., I.L.), Pharmacology (Y.B., C.C., R.D.M., I.L.), and Anesthesiology (R.D.M.), University of Illinois at Chicago; Department of Medicine, University of Chicago, IL (R.-T.H., Y.F.); and Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO (E.B.).
David T EddingtonFrom the Division of Pulmonary and Critical Care (E.L.M., C.Z., T.-P.S., I.S.F., I.L.), Division of Endocrinology (P.V.S.), Division of Hematology and Oncology, Department of Medicine (Y.S., Z.Q.), and Departments of Bioengineering (E.L.M., T.-P.S., C.N., T.C., D.T.E., J.L., M.C., I.L.), Pharmacology (Y.B., C.C., R.D.M., I.L.), and Anesthesiology (R.D.M.), University of Illinois at Chicago; Department of Medicine, University of Chicago, IL (R.-T.H., Y.F.); and Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO (E.B.).
James LeeFrom the Division of Pulmonary and Critical Care (E.L.M., C.Z., T.-P.S., I.S.F., I.L.), Division of Endocrinology (P.V.S.), Division of Hematology and Oncology, Department of Medicine (Y.S., Z.Q.), and Departments of Bioengineering (E.L.M., T.-P.S., C.N., T.C., D.T.E., J.L., M.C., I.L.), Pharmacology (Y.B., C.C., R.D.M., I.L.), and Anesthesiology (R.D.M.), University of Illinois at Chicago; Department of Medicine, University of Chicago, IL (R.-T.H., Y.F.); and Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO (E.B.).
Michael ChoFrom the Division of Pulmonary and Critical Care (E.L.M., C.Z., T.-P.S., I.S.F., I.L.), Division of Endocrinology (P.V.S.), Division of Hematology and Oncology, Department of Medicine (Y.S., Z.Q.), and Departments of Bioengineering (E.L.M., T.-P.S., C.N., T.C., D.T.E., J.L., M.C., I.L.), Pharmacology (Y.B., C.C., R.D.M., I.L.), and Anesthesiology (R.D.M.), University of Illinois at Chicago; Department of Medicine, University of Chicago, IL (R.-T.H., Y.F.); and Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO (E.B.).
Yun FangFrom the Division of Pulmonary and Critical Care (E.L.M., C.Z., T.-P.S., I.S.F., I.L.), Division of Endocrinology (P.V.S.), Division of Hematology and Oncology, Department of Medicine (Y.S., Z.Q.), and Departments of Bioengineering (E.L.M., T.-P.S., C.N., T.C., D.T.E., J.L., M.C., I.L.), Pharmacology (Y.B., C.C., R.D.M., I.L.), and Anesthesiology (R.D.M.), University of Illinois at Chicago; Department of Medicine, University of Chicago, IL (R.-T.H., Y.F.); and Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO (E.B.).
Richard D MinshallFrom the Division of Pulmonary and Critical Care (E.L.M., C.Z., T.-P.S., I.S.F., I.L.), Division of Endocrinology (P.V.S.), Division of Hematology and Oncology, Department of Medicine (Y.S., Z.Q.), and Departments of Bioengineering (E.L.M., T.-P.S., C.N., T.C., D.T.E., J.L., M.C., I.L.), Pharmacology (Y.B., C.C., R.D.M., I.L.), and Anesthesiology (R.D.M.), University of Illinois at Chicago; Department of Medicine, University of Chicago, IL (R.-T.H., Y.F.); and Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO (E.B.).
Irena LevitanFrom the Division of Pulmonary and Critical Care (E.L.M., C.Z., T.-P.S., I.S.F., I.L.), Division of Endocrinology (P.V.S.), Division of Hematology and Oncology, Department of Medicine (Y.S., Z.Q.), and Departments of Bioengineering (E.L.M., T.-P.S., C.N., T.C., D.T.E., J.L., M.C., I.L.), Pharmacology (Y.B., C.C., R.D.M., I.L.), and Anesthesiology (R.D.M.), University of Illinois at Chicago; Department of Medicine, University of Chicago, IL (R.-T.H., Y.F.); and Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO (E.B.). levitan@uic.edu.
University of Chicago · US
Funding
TRPC6 Regulation of Lung Endothelial Barrier FunctionP01HL060678 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MALIK, ASRAR B. · 2000 to 2020
$40.1MTRAINING PROGRAM IN LUNG BIOLOGY AND PATHOBIOLOGYT32HL007829 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DOLLY MEHTA · 1995 to 2026
$15.6MCholesterol Regulation of Endothelial K+ ChannelsR01HL073965 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LEVITAN, IRENA · 2004 to 2024
$7.3MImpact of dyslipidemia on endothelial biomechanicsR01HL083298 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LEVITAN, IRENA, MINSHALL, RICHARD D · 2007 to 2021
$7.0MRoles of Tau Oligomers in Alzheimer's VasculopathyR01AG044404 · NIA · UNIVERSITY OF MISSOURI-COLUMBIA · PI LEE, JAMES C · 2014 to 2024
$3.5MNew Strategies for Treating Septic Vasculopathy Inflammation and ThrombosisR01HL125356 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BONINI, MARCELO G., DU, XIAOPING · 2014 to 2018
$3.4MCoronary artery disease locus 1p32.2 and miR92a-PPAP2B signaling in endothelial mechanobiologyR01HL136765 · NHLBI · UNIVERSITY OF CHICAGO · PI FANG, YUN · 2017 to 2021
$2.0MmiR-10a regulation of regional arterial endothelial phenotypes in atherosclerosisR00HL103789 · NHLBI · UNIVERSITY OF CHICAGO · PI FANG, YUN · 2013 to 2015
$729kNHLBI NIH HHS P01 HL060678NHLBI NIH HHS R00 HL103789NHLBI NIH HHS R01 HL073965NHLBI NIH HHS R01 HL083298NHLBI NIH HHS R01 HL125356NHLBI NIH HHS R01 HL136765NHLBI NIH HHS T32 HL007829NIA NIH HHS R01 AG044404
Abstract
objectiveDisturbed flow (DF) is well-known to induce endothelial dysfunction and synergistically with plasma dyslipidemia facilitate plaque formation. Little is known, however, about the synergistic impact of DF and dyslipidemia on endothelial biomechanics. Our goal was to determine the impact of DF on endothelial stiffness and evaluate the role of dyslipidemia/oxLDL (oxidized low-density lipoprotein) in this process. APPROACH AND
resultsEndothelial elastic modulus of intact mouse aortas ex vivo and of human aortic endothelial cells exposed to laminar flow or DF was measured using atomic force microscopy. Endothelial monolayer of the aortic arch is found to be significantly stiffer than the descending aorta (4.2+1.1 versus 2.5+0.2 kPa for aortic arch versus descending aorta) in mice maintained on low-fat diet. This effect is significantly exacerbated by short-term high-fat diet (8.7+2.5 versus 4.5+1.2 kPa for aortic arch versus descending aorta). Exposure of human aortic endothelial cells to DF in vitro resulted in 50% increase in oxLDL uptake and significant endothelial stiffening in the presence but not in the absence of oxLDL. DF also increased the expression of oxLDL receptor CD36 (cluster of differentiation 36), whereas downregulation of CD36 abrogated DF-induced endothelial oxLDL uptake and stiffening. Furthermore, genetic deficiency of CD36 abrogated endothelial stiffening in the aortic arch in vivo in mice fed either low-fat diet or high-fat diet. We also show that the loss of endothelial stiffening in CD36 knockout aortas is not mediated by the loss of CD36 in circulating cells.
conclusionsDF facilitates endothelial CD36-dependent uptake of oxidized lipids resulting in local increase of endothelial stiffness in proatherogenic areas of the aorta.
Indexed as
Vascular StiffnessAnimalsAortaAortic DiseasesAtherosclerosisBiological TransportCD36 AntigensCells, CulturedDisease Models, AnimalDyslipidemiasElastic ModulusEndothelial CellsEndothelium, VascularHumansLipoproteins, LDLMice, KnockoutCD36 AntigensLipoproteins, LDLoxidized low density lipoproteinaortaatherosclerosischolesterol esterselastic modulusendothelial cells
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