Evidence map›Paper›PMID 29025592›Full record

SynthesisCancer genetics2017

Significantly mutated genes and regulatory pathways in SCLC-a meta-analysis.

Varsha Sundaresan, Victor T Lin, Faming Liang, Frederic J Kaye, Reika Kawabata-Iwakawa, Kouya Shiraishi, Takashi Kohno, Jun Yokota, Lei Zhou

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cancer genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Genes, fuel, and fate in lung cancer.Biochemical Society transactions · 2026
    Review
  3. Review
  4. Article
  5. Advances in Small-Cell Lung Cancer (SCLC) Translational Research.Cold Spring Harbor perspectives in medicine · 2021
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Varsha SundaresanDepartment of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL, USA; UF Health Cancer Center, University of Florida, Gainesville, FL, USA.
Victor T LinDepartment of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL, USA.
Faming LiangDepartment of Biostatistics, University of Florida, Gainesville, FL, USA.
Frederic J KayeUF Health Cancer Center, University of Florida, Gainesville, FL, USA; Department of Medicine, University of Florida, Gainesville, FL, USA; UF Genetics Institute, University of Florida, Gainesville, FL, USA.
Reika Kawabata-IwakawaDivision of Genome Biology, National Cancer Center Research Institute, Tokyo 104-0045, Japan.
Kouya ShiraishiDivision of Genome Biology, National Cancer Center Research Institute, Tokyo 104-0045, Japan.
Takashi KohnoDivision of Genome Biology, National Cancer Center Research Institute, Tokyo 104-0045, Japan; Division of Translational Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Tokyo 104-0045, Japan.
Jun YokotaDivision of Genome Biology, National Cancer Center Research Institute, Tokyo 104-0045, Japan; Cancer Genome Biology Group, Institute of Predictive and Personalized Medicine of Cancer, Barcelona 08916, Spain.
Lei ZhouDepartment of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL, USA; UF Health Cancer Center, University of Florida, Gainesville, FL, USA; UF Genetics Institute, University of Florida, Gainesville, FL, USA. Electronic address: leizhou@ufl.edu.
University of Florida · USNational Cancer Centre Japan · JP

Funding

The regulation of cell death in vivoR01GM110477 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI WHITE, KRISTIN, ZHOU, LEI · 2015 to 2018
$1.4M
Rapid Induction of apoptosis against viral infectionR01GM106174 · NIGMS · UNIVERSITY OF FLORIDA · PI ZHOU, LEI · 2014 to 2017
$1.1M
NIGMS NIH HHS R01 GM106174NIGMS NIH HHS R01 GM110477
6 · The paper itself

Abstract

Small cell lung cancer (SCLC) accounts for approximately 15% of all lung cancers and demands effective targeted therapeutic strategies. In this meta-analysis study, we aim to identify significantly mutated genes and regulatory pathways to help us better understand the progression of SCLC and to identify potential biomarkers. Besides ranking genes based on their mutation frequencies, we sought to identify statistically significant mutations in SCLC with the MutSigCV software. Our analysis identified several genes with relatively low mutation frequency, including PTEN, as highly significant (p < 0.001), suggesting these genes may play an important role in the progression of SCLC. Our results also indicated mutations in genes involved in the axon guidance pathways likely play an important role in SCLC progression. In addition, we observed that the mutation rate was significantly higher in samples with RB1 gene mutated when compared to samples with wild type RB1, suggesting that RB1 status has significant impact on the mutation profile and disease progression in SCLC.

Indexed as

Axon GuidanceCluster AnalysisDatabases, GeneticHumansLung NeoplasmsMutationMutation RateRetinoblastoma ProteinSignal TransductionSmall Cell Lung CarcinomaRetinoblastoma Proteinhigh-throughput sequencing datameta-analysisPTENRB1significantly mutated genesSmall cell lung cancer

Identifiers

PMID29025592
PMCPMC5677515
OpenAlexW2623679705

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.