Trial reportThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2017
Depressive symptoms and hazardous/harmful alcohol use are prevalent and correlate with stigma among TB-HIV patients in Lesotho.
Trial report in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Prevalence and associated factors for alcohol use disorder among tuberculosis patients: a systematic review and meta-analysis study.Substance abuse treatment, prevention, and policy · 2021Pooled it
- Qualitative study of patient experiences of mental distress during TB investigation and treatment in Zambia.BMC psychology · 2022Trial
- Prevalence, determinants, and Help-Seeking behavior for major depressive disorder symptoms in the Lesotho population: A multilevel analysis from the Lesotho demographic and health survey 2023-24.Social psychiatry and psychiatric epidemiology · 2026Article
- Delays in Tuberculosis Treatment Among People With Pulmonary Tuberculosis in East Africa: Findings From a Prospective Cohort Study.Open forum infectious diseases · 2026Article
- Intersectional Stigma and Health of People Living with HIV on ART Who Use Alcohol in Southwestern Uganda.AIDS and behavior · 2026Article
- Review
- Patient and provider perceptions of the relationship between alcohol use and TB and readiness for treatment: a qualitative study in South Africa.BMC public health · 2024Article
- A Systematic Review and Psychometric Appraisal of Instruments Measuring Tuberculosis Stigma in Sub-Saharan Africa.Stigma and health · 2024Article
- Cognitive dissonance in tuberculosis stigma: A mixed methods analysis of tuberculosis stigma measurement in South Africa.PLOS global public health · 2024Article
- Non-AIDS-defining comorbidities impact health related quality of life among older adults living with HIV.Frontiers in medicine · 2024Article
- Patient and provider perceptions of the relationship between alcohol use and TB and readiness for treatment: a qualitative study in South Africa.Research square · 2023Article
- Harmful Alcohol Use Among Patients with Tuberculosis in Gedeo Zone, Southern Ethiopia.Substance abuse and rehabilitation · 2022Article
- Electronic Dose Monitoring Identifies a High-Risk Subpopulation in the Treatment of Drug-resistant Tuberculosis and Human Immunodeficiency Virus.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- TB stigma and its correlates among HIV-positive people who inject drugs in Ukraine.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2021Article
- Major Depression and Stigma among Individuals with Multidrug-Resistant Tuberculosis in South Africa.The American journal of tropical medicine and hygiene · 2020Article
- The prevalence of depression among patients with tuberculosis: a systematic review and meta-analysis.Annals of general psychiatry · 2020Review
- A scoping review of health-related stigma outcomes for high-burden diseases in low- and middle-income countries.BMC medicine · 2019Article
- Challenges and opportunities in examining and addressing intersectional stigma and health.BMC medicine · 2019Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
settingLimited data exist on the prevalence and correlates, including stigma, of mental health conditions, including depressive symptoms and alcohol use, among patients co-infected with tuberculosis (TB) and the human immunodeficiency virus (HIV) in sub-Saharan Africa, despite their negative impact on health outcomes.
objectiveTo assess the prevalence and correlates of depressive symptoms and hazardous/harmful alcohol use among TB-HIV patients in the Start TB patients on ART and Retain on Treatment (START) study.
designSTART, a mixed-methods cluster-randomized trial, evaluated a combination intervention package vs. standard of care (SOC) to improve treatment outcomes in TB-HIV co-infected patients in Lesotho. Moderate/severe depressive symptoms and hazardous/harmful alcohol use were measured using baseline questionnaire data collected from April 2013 to March 2015. Demographic, psychosocial, and TB- and HIV-related knowledge and attitudes, including stigma, were assessed for association with both conditions using generalized linear mixed models.
resultsAmong 371 participants, 29.8% reported moderate/severe depressive symptoms, and 24.7% reported hazardous/harmful alcohol use; 7% reported both. Depressive symptoms were significantly associated with less education, more difficulty understanding written medical information, non-disclosure of TB, greater TB stigma, and the SOC study arm. Hazardous/harmful alcohol use was significantly associated with male sex, as well as greater TB and external HIV stigma.
conclusionPrevalence of depressive symptoms and hazardous/harmful alcohol use were high, suggesting a need for routine screening for, and treatment of, mental health disorders in TB-HIV patients.
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