SynthesisItalian journal of pediatrics2017
Specific IgE and skin prick tests to diagnose allergy to fresh and baked cow's milk according to age: a systematic review.
Synthesis in Italian journal of pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Biomarkers associated with persistence and severity of IgE-mediated food allergies: a systematic review.Jornal de pediatriaPooled it
- Evidence-Based Clinical Recommendations on the Appropriateness of Prescriptions and Diagnostic Tests in Paediatric Allergology: Focus on IgE-Mediated and Non-IgE Mediated Food Allergy, Eosinophilic Gastrointestinal Disease, Urticaria, Angioedema and Atopic Dermatitis.Children (Basel, Switzerland) · 2026Review
- Response to venom immunotherapy: Exploratory retrospective machine learning clustering analysis.The journal of allergy and clinical immunology. Global · 2026Article
- Article
- Cow milk protein allergy mimics in infancy.World journal of clinical pediatrics · 2025Review
- Cow's Milk Allergy and Associated Factors Among Children in Abha City, Saudi Arabia - A Retrospective Case Control Study.Journal of asthma and allergy · 2025Article
- Metabolomics in Children Cow's Milk Protein Allergy: Possible Contribution from a System Biology Approach?Children (Basel, Switzerland) · 2024Review
- Basophil allergen threshold sensitivity to casein (casein-specific CD-sens) predicts allergic reactions at a milk challenge in most but not all patients.Immunity, inflammation and disease · 2024Article
- Metabolic Syndrome and Biotherapeutic Activity of Dairy (Cow and Buffalo) Milk Proteins and Peptides: Fast Food-Induced Obesity Perspective-A Narrative Review.Biomolecules · 2024Review
- Milk Allergen Micro-Array (MAMA) for Refined Detection of Cow's-Milk-Specific IgE Sensitization.Nutrients · 2023Article
- IgE-mediated cow's milk allergy in Brazilian children: Outcomes of oral food challenge.The World Allergy Organization journal · 2023Article
- Molecular Allergy Diagnostics in Children with Cow's Milk Allergy: Prediction of Oral Food Challenge Response in Clinical Practice.Journal of immunology research · 2023Article
- Oral Immunotherapy for Children with Cow's Milk Allergy: A Practical Approach.Children (Basel, Switzerland) · 2022Article
- Four clinical phenotypes of cow's milk protein allergy based on dairy product specific IgE antibody types in North China.Frontiers in immunology · 2022Article
- Low Levels Matter: Clinical Relevance of Low Pru p 3 sIgE in Patients With Peach Allergy.Frontiers in allergy · 2022Article
- Skin prick test in milk allergic patients undergoing oral immunotherapy: Does the milk form used for skin tests matter?Frontiers in allergy · 2022Article
- Prick-by-Prick Test with Pasteurised Cow's Milk: A Valuable Tool in Paediatric Practice.BioMed research international · 2022Article
- Update on food allergy.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2021Review
- Cow's Milk Protein Allergy as a Model of Food Allergies.Nutrients · 2021Review
- Food allergy: an updated review on pathogenesis, diagnosis, prevention and management.Acta bio-medica : Atenei Parmensis · 2020Review
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe diagnosis of IgE-mediated cow's milk allergy is often based on anamnesis, and on specific IgE (sIgE) levels and/or Skin Prick Tests (SPT), which have both a good sensitivity but a low specificity, often causing positive results in non-allergic subjects. Thus, oral food challenge is still the gold standard test for diagnosis, though being expensive, time-consuming and possibly at risk for severe allergic reactions.
aimThe aim of the present study was to perform a systematic review of the studies that have so far analyzed the positive predictive values for sIgE and SPT in the diagnosis of allergy to fresh and baked cow's milk according to age, and to identify possible cut-offs that may be useful in clinical practice.
methodsA comprehensive search on Medline via PubMed and Scopus was performed August 2017. Studies were included if they investigated possible sIgE and/or SPT cut-off values for cow's milk allergy diagnosis in pediatric patients. The quality of the studies was evaluated according to QUADAS-2 criteria.
resultsThe search produced 471 results on Scopus, and 2233 on PubMed. Thirty-one papers were included in the review and grouped according to patients' age, allergen type and cooking degree of the milk used for the oral food challenge. In children < 2 years, CMA diagnosis seems to be highly likely when sIgE to CM extract are ≥ 5 KU
conclusionsNone of the cut-offs proposed in the literature can be used to definitely confirm cow's milk allergy diagnosis, either to fresh pasteurized or to baked milk. However, in children < 2 years, cut-offs for specific IgE or SPT seem to be more homogeneous and may be proposed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.