Evidence map›Paper›PMID 29025410›Full record

Observational studyBMC geriatrics2017

Association between traditional cardiovascular risk factors and mortality in the oldest old: untangling the role of frailty.

Bert Vaes, David Depoortere, Gijs Van Pottelbergh, Catharina Matheï, Joana Neto, Jan Degryse

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC geriatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 3 pooled it
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 59 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Bert VaesDepartment of Public Health and Primary Care, Universiteit Leuven (KU Leuven), Leuven, Belgium. bert.vaes@kuleuven.be.ORCID 0000-0001-5244-1930
David DepoortereDepartment of Public Health and Primary Care, Universiteit Leuven (KU Leuven), Leuven, Belgium.
Gijs Van PottelberghDepartment of Public Health and Primary Care, Universiteit Leuven (KU Leuven), Leuven, Belgium.
Catharina MatheïDepartment of Public Health and Primary Care, Universiteit Leuven (KU Leuven), Leuven, Belgium.
Joana NetoInstitute of Health and Society, Université catholique de Louvain (UCL), Brussels, Belgium.
Jan DegryseDepartment of Public Health and Primary Care, Universiteit Leuven (KU Leuven), Leuven, Belgium.
KU Leuven · BEUCLouvain · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo date, there is no consensus regarding cardiovascular risk management in the very old. Studies have shown that the relationship between traditional cardiovascular risk factors and mortality is null or even inverted within this age group. This relationship could be modified by the presence of frailty. This study was performed to examine the effect of frailty on the association between cardiovascular risk factors and mortality in the oldest old.

methodsThe BELFRAIL study is a prospective, observational, population-based cohort study of 567 subjects aged 80 years and older. Data on cardiovascular risk factors were recorded. Frailty was assessed using three different models: the Groningen Frailty Indicator, Fried and Puts models. Participants were considered robust if they were 'not frail' according to all three models, and frail if they met the frailty criteria for one of the three models. The follow-up data on mortality and cause of death were registered.

resultsNo cardiovascular risk factor was associated with mortality in subjects with and without cardiovascular disease. The presence of frailty was a strong risk factor for mortality [HR: 2.5, 95%CI: (1.9-3.2) for all-cause mortality; HR: 2.2, 95%CI: (1.4-3.4) for cardiovascular mortality]. In robust patients, a history of cardiovascular disease increased the risk for mortality [HR: 1.7, 95%CI: (1.1-2.5) for all-cause mortality; HR: 2.2, 95%CI: (1.2-3.9) for cardiovascular mortality]. In frail patients, there was no association between any of the traditional risk factors and mortality.

conclusionsTraditional cardiovascular risk factors were not associated with mortality in very old subjects. Frailty was shown to be a strong risk factor for mortality in this age group. However, frailty could not be used to identify additional subjects who might benefit more from cardiovascular risk management.

Indexed as

Aged, 80 and overCardiovascular DiseasesFemaleFrail ElderlyFrailtyHumansMaleProspective StudiesRisk FactorsCardiovascular risk predictionCholesterolFrailtyHypertensionMortality

Identifiers

PMID29025410
PMCPMC5639737
OpenAlexW2763527805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.