ArticleAnnals of pediatric endocrinology & metabolism2017
Diurnal variation of gonadotropin levels in girls with early stages of puberty.
Article in Annals of pediatric endocrinology & metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Diagnostic utility of basal luteinizing hormone in evaluating central precocious puberty.Journal of the Endocrine Society · 2026Article
- Critical appraisal of diagnostic laboratory tests in the evaluation of central precocious puberty.Frontiers in pediatrics · 2024Article
- 2022 Clinical practice guidelines for central precocious puberty of Korean children and adolescents.Annals of pediatric endocrinology & metabolism · 2023Article
- Slower progression of central puberty in overweight girls presenting with precocious breast development.Annals of pediatric endocrinology & metabolism · 2023Article
- [Value of basal luteinizing hormone level combined with uterine volume measurement in the early diagnosis of central precocious puberty in girls with different Tanner stages].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023Article
- Gonadotropin-releasing hormone stimulation test and diagnostic cutoff in precocious puberty: a mini review.Annals of pediatric endocrinology & metabolism · 2020Article
- Morning basal luteinizing hormone, a good screening tool for diagnosing central precocious puberty.Annals of pediatric endocrinology & metabolism · 2019Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePubertal gonadotropin secretion shows circadian pattern and the luteinizing hormone (LH) levels tend to rise in later stages of puberty in girls. We studied the usefulness of basal LH in the evaluation of central precocious puberty with emphasis on the influence of sampling time.
methodsMedical records of 334 girls that underwent gonadotropin-releasing hormone stimulation test (GnRHST) were reviewed. Auxological and laboratory data were compared between those with early morning (EM, before 10 AM) and late morning/afternoon (LM/A, after 10 AM) basal samples.
resultsAmong those in sexual maturity rating (SMR) 2, EM samples showed higher basal LH (P=0.004) compare to LM/A samples, whereas those in SMR 3 showed no difference in LH levels between EM and LM/A samples. Among girls with pubertal response, EM group showed higher basal LH (P=0.031) and follicular stimulating hormone (P=0.008) than LM/A group. The EM basal LH was more closely related with the peak stimulated LH than the LM/A basal LH did (rs=0.871 vs. rs=0.524). The optimal basal LH cutoffs to predict a pubertal response to GnRHST were 0.11 IU/L with a sensitivity of 66.7% and a specificity of 78.7% in EM group, and 0.07 IU/L with a sensitivity of 60.0% and a specificity of 78.9% in LM/A group, respectively.
conclusionsIn girls with early stages of puberty, EM basal LH is a more sensitive screening tool than the LM/A basal LH. Diurnal variation should be considered in evaluating children with precocious puberty.
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