ArticleDiseases of the esophagus : official journal of the International Society for Diseases of the Esophagus2018
Impact of smoking, alcohol consumption, and NSAID use on risk for and phenotypes of eosinophilic esophagitis.
Article in Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Systematic Review: Variability in Definitions of Fibrostenosis in Eosinophilic Oesophagitis.Alimentary pharmacology & therapeutics · 2025Pooled it
- Gastroesophageal disease risk and inhalational exposure a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- Heartburn and dyspepsia symptom severity improves after treatment and correlates with histology in adults with eosinophilic esophagitis.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2019Trial
- Eosinophilic gastrointestinal diseases.Nature reviews. Disease primers · 2026Review
- Plasma glutathione peroxidase activity negatively correlates with atopic diseases in children but not adults: an exploratory study.Frontiers in allergy · 2026Article
- Physiologic and molecular effects of alcohol in the esophagus: a narrative review.Annals of esophagus · 2025Article
- Epidemiology, risk factors and natural history of eosinophilic esophagitis in patients with inflammatory bowel disease: a population-based cohort study from the United States.Annals of gastroenterology · 2025Article
- Clinical and atopic features of patients with primary eosinophilic colitis: an Italian multicentre study.Internal and emergency medicine · 2024Article
- Emotional Journey of Patients with Eosinophilic Esophagitis.Advances in therapy · 2023Article
- A Case of Early Barrett's Adenocarcinoma With Eosinophilic Esophagitis.ACG case reports journal · 2023Article
- Eosinophilic Esophagitis-What Do We Know So Far?Journal of clinical medicine · 2023Review
- Mortality and cancer in eosinophilic gastrointestinal disorders distal to the esophagus: nationwide cohort study 1990-2017.Journal of gastroenterology · 2022Article
- Immunogenetic, Molecular and Microbiotic Determinants of Eosinophilic Esophagitis and Clinical Practice-A New Perspective of an Old Disease.International journal of molecular sciences · 2021Review
- Obesity reduces the requirement for subsequent esophageal stricture dilation in adults with eosinophilic esophagitis.Esophagus : official journal of the Japan Esophageal Society · 2021Article
- Eosinophilic esophagitis-established facts and new horizons.Seminars in immunopathology · 2021Review
- Early life factors are associated with risk for eosinophilic esophagitis diagnosed in adulthood.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2021Article
- Gastroprotective effects of the nonsaponin fraction of Korean Red Ginseng through cyclooxygenase-1 upregulation.Journal of ginseng research · 2020Article
- Clinical and endoscopic characteristics of eosinophilic esophagitis in Japan: a case-control study.Asia Pacific allergy · 2020Article
- Early Life Risk Factors in Pediatric EoE: Could We Prevent This Modern Disease?Frontiers in pediatrics · 2020Review
- Eosinophilic Gastrointestinal Disorders.Clinical reviews in allergy & immunology · 2019Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
There are few data exploring modifiable risk factors for eosinophilic esophagitis (EoE). We aimed to determine if smoking, alcohol consumption, and nonsteroidal anti-inflammatory drug (NSAID) use were risk factors for EoE, and to assess their impact on EoE phenotypes and treatment outcomes. We performed a case-control study analyzing data collected from a prospective cohort of adults undergoing upper endoscopy for symptoms of esophageal dysfunction. Incident EoE cases were diagnosed via consensus guidelines. Exposure data were collected via standardized patient questionnaire. Follow-up assessments for cases were made after treatment, with histologic response defined as <15 eosinophils per high-power field (eos/hpf). Exposures were compared between EoE cases and controls, among EoE cases with and without fibrostenosis, and among EoE responders and nonresponders. A total of 115 cases and 225 controls were analyzed. Cases were less likely to have ever smoked cigarettes (23% vs. 47%, P < 0.001) or currently use NSAIDs (17% vs. 40%, P < 0.001) compared to controls. These relations persisted after multivariate analysis. Although alcohol use was more common among cases (75% vs. 51%, P < 0.001), the effect was abrogated after multivariate analysis. Smoking, alcohol, and NSAID use were not associated with the fibrostenotic phenotype. There was a trend toward improved histologic response among EoE patients concomitantly using NSAIDs (87% vs. 63%, P = 0.08; aOR 6.97 (95% CI: 0.81-60.3). In conclusion, NSAID and smoking were inversely associated with EoE compared to endoscopy-based controls. Alcohol use was more prevalent in the EoE cases, although not an independent risk factor. Concomitant NSAID use may improve treatment response and is worthy of future study.
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