ArticleNeuron2017
Loss of CLOCK Results in Dysfunction of Brain Circuits Underlying Focal Epilepsy.
Open access · bronzeAbstract read
In one paragraph
Article in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 8% of its field
What it found
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Who cites it
59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Clock gene dysregulation in epilepsy: A systematic review.Epilepsia open · 2026Pooled it
- Epilepsy Occurrence and Circadian Rhythm: A Bibliometrics Study and Visualization Analysis via CiteSpace.Frontiers in neurology · 2020Pooled it
- Circadian Rhythms Time Seizure Severity inJournal of biological rhythms · 2026Article
- Review
- Sex hormone dysregulation after traumatic brain injury: interactions with sleep disturbances and seizure susceptibility.Frontiers in neuroscience · 2026Review
- Circadian rhythms in pediatric neurocritical care: interfaces and opportunities.Frontiers in neurology · 2026Review
- Aberrant neural activity in the peritumoral cortex underlies the progression of tumor-associated seizures.Nature communications · 2025Article
- The intersection of circadian rhythms and the blood-brain barrier with drug efficacy and delivery in neurological disorders.Advanced drug delivery reviews · 2025Review
- Astrocyte FABP7 Modulates Seizure Activity-Dependent Protein Expression in Mouse Brain.Neuroglia (Basel, Switzerland) · 2025Article
- Human CLOCK enhances neocortical function.Nature neuroscience · 2025Article
- More variable circadian rhythms in epilepsy captured by long-term heart rate recordings from wearable sensors.Epilepsia · 2025Article
- Gene therapies alleviate absence epilepsy associated withbioRxiv : the preprint server for biology · 2025Article
- Factors Affecting Sleep and Wakefulness in People with Epilepsy: A Narrative Review.Medicina (Kaunas, Lithuania) · 2025Review
- Mechanistic insights into the interaction between epilepsy and sleep.Nature reviews. Neurology · 2025Review
- Sleep links hippocampal propensity for epileptiform activity to its viscerosensory inputs.Frontiers in neuroscience · 2025Article
- Clinical daily rhythms of seizure in different subtypes of temporal lobe epilepsy.Frontiers in neurology · 2025Article
- Developmental mechanisms underlying pediatric epilepsy.Frontiers in neurology · 2025Review
- Chronobiology in Paediatric Neurological and Neuropsychiatric Disorders: Harmonizing Care with Biological Clocks.Journal of clinical medicine · 2024Review
- Timing Mechanisms for Circadian Seizures.Clocks & sleep · 2024Review
- The Role of Circadian Rhythm in Neurological Diseases: A Translational Perspective.Aging and disease · 2024Review
Corrections and comments
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Authors and funding
28 authors at 8 institutions in 2 countries.
Peijun LiCenter for Neuroscience Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USA. Electronic address: peijun.li@va.gov.
Xiaoqin FuCenter for Neuroscience Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USA; The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
Nathan A SmithCenter for Neuroscience Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USA.
Julie ZiobroCenter for Neuroscience Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USA.
Julian CurielCenter for Neuroscience Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USA.
Milagros J TengaVirginia Tech Carillion Research Institute; Roanoke, VA 24014, USA.
Brandon MartinCenter for Neuroscience Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USA.
Samuel FreedmanDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Pediatrics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Christian A Cea-Del RioDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Pediatrics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Livio ObotiCenter for Neuroscience Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USA.
Tammy N TsuchidaComprehensive Pediatric Epilepsy Program, Division of Neurophysiology and Epilepsy, Children's National Health Medical Center; Washington, DC 20010 USA.
Chima OluigboComprehensive Pediatric Epilepsy Program, Division of Neurophysiology and Epilepsy, Children's National Health Medical Center; Washington, DC 20010 USA; Division of Neurosurgery, Children's National Medical Center, Washington, DC 20010, USA.
Amanda YaunComprehensive Pediatric Epilepsy Program, Division of Neurophysiology and Epilepsy, Children's National Health Medical Center; Washington, DC 20010 USA; Division of Neurosurgery, Children's National Medical Center, Washington, DC 20010, USA.
Suresh N MaggeComprehensive Pediatric Epilepsy Program, Division of Neurophysiology and Epilepsy, Children's National Health Medical Center; Washington, DC 20010 USA; Division of Neurosurgery, Children's National Medical Center, Washington, DC 20010, USA.
Brent O'NeillDivision of Pediatric Neurosurgery, School of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
Amy KaoComprehensive Pediatric Epilepsy Program, Division of Neurophysiology and Epilepsy, Children's National Health Medical Center; Washington, DC 20010 USA.
Tesfaye G ZellekeComprehensive Pediatric Epilepsy Program, Division of Neurophysiology and Epilepsy, Children's National Health Medical Center; Washington, DC 20010 USA.
Dewi T Depositario-CabacarComprehensive Pediatric Epilepsy Program, Division of Neurophysiology and Epilepsy, Children's National Health Medical Center; Washington, DC 20010 USA.
Svetlana GhimbovschiCenter for Genetic Medicine, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USA.
Susan KnoblachCenter for Genetic Medicine, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USA.
Chen-Ying HoCenter for Genetic Medicine, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USA; Division of Pathology, Children's National Medical Center; Washington, DC 20010, USA.
Joshua G CorbinCenter for Neuroscience Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USA.
Howard P GoodkinDepartments of Neurology and Pediatrics, University of Virginia Health System, Charlottesville, VA 22908, USA.
Stefano ViciniDepartment of Pharmacology and Physiology, Georgetown University, Washington, DC 20057, USA.
Molly M HuntsmanDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Pediatrics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
William D GaillardCenter for Neuroscience Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USA; Comprehensive Pediatric Epilepsy Program, Division of Neurophysiology and Epilepsy, Children's National Health Medical Center; Washington, DC 20010 USA.
Gregorio ValdezVirginia Tech Carillion Research Institute; Roanoke, VA 24014, USA; Department of Biological Sciences, Virginia Tech; Blacksburg, VA 24061, USA.
Judy S LiuCenter for Neuroscience Research, Children's Research Institute, Children's National Medical Center, Washington, DC 20010, USA. Electronic address: judy_liu@brown.edu.
Children's National · USWashington Center · USUniversity of Colorado Anschutz Medical Campus · USRoanoke College · USGeorgetown University · USUniversity of Montana · USUniversity of Virginia Health System · USWenzhou Medical University · CN
Funding
NEUROIMAGING COREP30HD040677 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI VITTORIO GALLO, VITTORIO GALLO VITTORIO GALLO · 2001 to 2015
$15.9MClinical and Translational Science Institute at Children's NationalUL1TR000075 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI GUAY-WOODFORD, LISA MARIE · 2012 to 2015
$13.7MNCMRR-DC Core Molecular & Functional Outcome Measures in Rehabilitation MedicineR24HD050846 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI KNOBLACH, SUSAN M · 2005 to 2014
$8.6MCTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR031988 · NCRR · CHILDREN'S RESEARCH INSTITUTE · PI GUAY-WOODFORD, LISA MARIE · 2010 to 2011
$8.2MDevelopment of the Basal Telencephalic Limbic SystemR01DA020140 · NIDA · GEORGETOWN UNIVERSITY · PI CORBIN, JOSHUA G · 2006 to 2020
$7.3MResearch_ProjectU54HD090257 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI VITTORIO GALLO, VITTORIO GALLO VITTORIO GALLO · 2016 to 2020
$5.9MTargeting the fibroblast growth factor binding protein-1 to slow degeneration of neuromuscular junctionsR01AG055545 · NIA · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI VALDEZ, GREGORIO · 2017 to 2021
$2.2MAssembly and Function of Olfactory Circuitry from Dbxl-derived Neural ProgenitorsR01DC012050 · NIDCD · CHILDREN'S RESEARCH INSTITUTE · PI CORBIN, JOSHUA G · 2013 to 2017
$1.8MPostdoctoral Training in Developmental Disabilities ResearchT32HD046388 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI VITTORIO GALLO, VITTORIO GALLO VITTORIO GALLO · 2006 to 2016
$1.5MCortical circuit dysfunction in fragile x syndromeR01NS095311 · NINDS · UNIVERSITY OF COLORADO DENVER · PI HUNTSMAN, MOLLY-MAUREEN · 2015 to 2018
$1.4MTesting the excitability of inhibitory neuronsR01NS053719 · NINDS · GEORGETOWN UNIVERSITY · PI HUNTSMAN, MOLLY-MAUREEN · 2007 to 2010
$1.1MRole of Target-derived FGFs in Maintaining and Repairing SynapsesK01NS085071 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI VALDEZ, GREGORIO · 2013 to 2015
$679kNCATS NIH HHS UL1 TR000075NCRR NIH HHS UL1 RR031988NIA NIH HHS R01 AG055545NIA NIH HHS R56 AG051501NICHD NIH HHS P30 HD040677NICHD NIH HHS R24 HD050846NICHD NIH HHS T32 HD046388NICHD NIH HHS U54 HD090257NIDA NIH HHS R01 DA020140NIDCD NIH HHS R01 DC012050NINDS NIH HHS K01 NS085071NINDS NIH HHS R01 NS053719NINDS NIH HHS R01 NS095311
Abstract
Because molecular mechanisms underlying refractory focal epilepsy are poorly defined, we performed transcriptome analysis on human epileptogenic tissue. Compared with controls, expression of Circadian Locomotor Output Cycles Kaput (CLOCK) is decreased in epileptogenic tissue. To define the function of CLOCK, we generated and tested the Emx-Cre; Clock
Indexed as
AnimalsBrainCells, CulturedCLOCK ProteinsEpilepsies, PartialFemaleHumansMaleMiceMice, Inbred C57BLMice, TransgenicNerve NetProspective StudiesClock protein, mouseCLOCK Proteinscircadian epilepsyfocal cortical dysplasiafocal epilepsytuberous sclerosis complex
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.