Evidence map›Paper›PMID 29024654›Full record

ReviewNeuron2017

Striatal Local Circuitry: A New Framework for Lateral Inhibition.

Dennis A Burke, Horacio G Rotstein, Veronica A Alvarez

Abstract readReview
In one paragraph

Review in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers.

0numbers the graph read from it
0cells of the map it votes in
155citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

155 citing papers in PubMed.

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95 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dennis A BurkeLaboratory on Neurobiology of Compulsive Behaviors, Intramural Research Program, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA; Department of Neuroscience, Brown University, Providence, Providence, RI 02912, USA.
Horacio G RotsteinFederated Department of Biological Sciences, New Jersey Institute of Technology and Rutgers University, Newark, NJ 07102, USA; Institute for Brain and Neuroscience Research, New Jersey Institute of Technology, Newark, NJ 07102, USA.
Veronica A AlvarezLaboratory on Neurobiology of Compulsive Behaviors, Intramural Research Program, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD 20892, USA; Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA. Electronic address: alvarezva@mail.nih.gov.

Funding

Synaptic mechanisms underlying reward seeking and compulsive drug useZIAAA000421 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI ALVAREZ, VERONICA A · 2009 to 2025
$23.1M
Ionic conductance correlations tune neuronal network activity to natural inputsR56NS085330 · NINDS · NEW JERSEY INSTITUTE OF TECHNOLOGY · PI GOLOWASCH, JORGE P, ROTSTEIN, HORACIO G. · 2014 to 2014
$383k
Intramural NIH HHS ZIA AA000421NINDS NIH HHS R56 NS085330
6 · The paper itself

Abstract

This Perspective will examine the organization of intrastriatal circuitry, review recent findings in this area, and discuss how the pattern of connectivity between striatal neurons might give rise to the behaviorally observed synergism between the direct/indirect pathway neurons. The emphasis of this Perspective is on the underappreciated role of lateral inhibition between striatal projection cells in controlling neuronal firing and shaping the output of this circuit. We review some classic studies in combination with more recent anatomical and functional findings to lay out a framework for an updated model of the intrastriatal lateral inhibition, where we explore its contribution to the formation of functional units of processing and the integration and filtering of inputs to generate motor patterns and learned behaviors.

Indexed as

AnimalsCorpus StriatumFunctional LateralityGABAergic NeuronsHumansNerve NetNeural Inhibition

Identifiers

PMID29024654
PMCPMC5649445

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.