Evidence map›Paper›PMID 29024590›Full record

ArticleACS combinatorial science2017

Efficient Synthesis of 1,9-Substituted Benzo[h][1,6]naphthyridin-2(1H)-ones and Evaluation of their Plasmodium falciparum Gametocytocidal Activities.

Hao Li, Wei Sun, Xiuli Huang, Xiao Lu, Paresma R Patel, Myunghoon Kim, Meghan J Orr, Richard M Fisher, Takeshi Q Tanaka, John C McKew and 5 more

Abstract read
In one paragraph

Article in ACS combinatorial science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. 1,6-Naphthyridin-2(1Pharmaceuticals (Basel, Switzerland) · 2021
    Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hao LiNational Center for Advancing Translational Sciences, National Institutes of Health , Bethesda, Maryland 20892, United States.
Wei SunNational Center for Advancing Translational Sciences, National Institutes of Health , Bethesda, Maryland 20892, United States.
Xiuli HuangNational Center for Advancing Translational Sciences, National Institutes of Health , Bethesda, Maryland 20892, United States.
Xiao LuNational Center for Advancing Translational Sciences, National Institutes of Health , Bethesda, Maryland 20892, United States.
Paresma R PatelNational Center for Advancing Translational Sciences, National Institutes of Health , Bethesda, Maryland 20892, United States.
Myunghoon KimNational Center for Advancing Translational Sciences, National Institutes of Health , Bethesda, Maryland 20892, United States.
Meghan J OrrNational Center for Advancing Translational Sciences, National Institutes of Health , Bethesda, Maryland 20892, United States.
Richard M FisherNational Center for Advancing Translational Sciences, National Institutes of Health , Bethesda, Maryland 20892, United States.
Takeshi Q TanakaLaboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland 20892, United States.
John C McKewNational Center for Advancing Translational Sciences, National Institutes of Health , Bethesda, Maryland 20892, United States.
Anton SimeonovNational Center for Advancing Translational Sciences, National Institutes of Health , Bethesda, Maryland 20892, United States.
Philip E SandersonNational Center for Advancing Translational Sciences, National Institutes of Health , Bethesda, Maryland 20892, United States.
Wei ZhengNational Center for Advancing Translational Sciences, National Institutes of Health , Bethesda, Maryland 20892, United States.
Kim C WilliamsonDepartment of Biology, Loyola University Chicago , Chicago, Illinois 60660, United States.
Wenwei HuangNational Center for Advancing Translational Sciences, National Institutes of Health , Bethesda, Maryland 20892, United States.ORCID 0000-0002-7727-9287

Funding

Small molecule screening programZ01HG200319 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI AUSTIN, CHRISTOPHER P · 2004 to 2008
$32.3M
Drug Repurposing Screening for Rare and Neglected DiseasesZIATR000018 · NCATS · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · PI ZHENG, WEI · 2015 to 2025
$24.6M
Development of Malaria Transmission-Blocking DrugsZIATR000013 · NCATS · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · PI HUANG, WENWEI · 2015 to 2025
$19.3M
Advancing gametocytocidal agents as drugs against P. falciparumR01AI114761 · NIAID · LOYOLA UNIVERSITY OF CHICAGO · PI WILLIAMSON, KIM C · 2015 to 2019
$1.9M
Targeting P. falciparum gametocytes for drug developmentR21AI101396 · NIAID · LOYOLA UNIVERSITY OF CHICAGO · PI WILLIAMSON, KIM C · 2012 to 2013
$374k
Intramural NIH HHS Z01 HG200319Intramural NIH HHS Z99 TR999999NIAID NIH HHS R01 AI114761NIAID NIH HHS R21 AI101396
6 · The paper itself

Abstract

A novel three-component, two-step, one-pot nucleophilic aromatic substitution (S

Indexed as

AntimalarialsCell LineCell SurvivalHumansNaphthyridinesPlasmodium falciparumSmall Molecule LibrariesAntimalarialsNaphthyridinesSmall Molecule Librariesbenzo[h][1,6]naphthyridin-2(1H)-onesgametocytocidal activitymalariaone-pot reactionquinolineTorin

Identifiers

PMID29024590
PMCPMC5870878

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.