Evidence map›Paper›PMID 29024417›Full record

ArticleAging cell2018

Human CD8

Lauren A Callender, Elizabeth C Carroll, Robert W J Beal, Emma S Chambers, Sussan Nourshargh, Arne N Akbar, Sian M Henson

Open access · goldAbstract read
In one paragraph

Article in Aging cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 175 papers.

0numbers the graph read from it
0cells of the map it votes in
175citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

175 citing papers in PubMed, 260 citations in OpenAlex.

  1. Trial
  2. Review
  3. CD8Immunity & ageing : I & A · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Aging diminishes thymic output, reduces naive T cells, promotes memory T-cell accumulation, and impairs thymic regeneration.American journal of physiology. Regulatory, integrative and comparative physiology · 2026
    Article
  8. Review
  9. Review
  10. CD8Science China. Life sciences · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Review

115 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Lauren A CallenderTranslational Medicine and Therapeutics, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Elizabeth C CarrollTranslational Medicine and Therapeutics, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Robert W J BealMicrovascular Research, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Emma S ChambersDivision of Infection and Immunity, University College London, London, WC1E 6JF, UK.
Sussan NoursharghMicrovascular Research, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Arne N AkbarDivision of Infection and Immunity, University College London, London, WC1E 6JF, UK.
Sian M HensonTranslational Medicine and Therapeutics, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Queen Mary University of London · GBUniversity College London · GBWilliam Harvey Research Institute · GB

Funding

Biotechnology and Biological Sciences Research Council BB/J006750/1Biotechnology and Biological Sciences Research Council BBS/B/04528Medical Research Council MR/M003833/1Medical Research Council MR/N017749/1Medical Research Council MR/P00184X/1
6 · The paper itself

Abstract

Cellular senescence is accompanied by a senescence-associated secretory phenotype (SASP). We show here that primary human senescent CD8

Indexed as

AdultCD8-Positive T-LymphocytesCellular SenescenceCytokinesDNA DamageHealthy VolunteersHumansMAP Kinase Signaling SystemMiddle Agedp38 Mitogen-Activated Protein KinasesPhenotypeCytokinesp38 Mitogen-Activated Protein KinasesagingcytokineinflammationmicroarraySASPT cell

Identifiers

PMID29024417
PMCPMC5770853
OpenAlexW2761280324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.