ArticlePest management science2018
Non-target site SDHI resistance is present as standing genetic variation in field populations of Zymoseptoria tritici.
Article in Pest management science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 88 citations in OpenAlex.
- Determining frequencies of fungicide resistance in Leptosphaeria maculans that render demethylation inhibitor fungicides ineffective in the field.Pest management science · 2026Article
- Cryo-EM structure of bixafen-bound S. cerevisiae complex II unravels SDHI specificity against pathogenic fungi.Communications biology · 2026Article
- Identification of succinate dehydrogenase inhibitor-resistance mutations, T78I, N85K/S, and H151R, in theJournal of pesticide science · 2025Article
- Evolution of antifungal resistance in the environment.Nature microbiology · 2025Review
- Baseline sensitivity of European Zymoseptoria tritici populations to the complex III respiration inhibitor fenpicoxamid.Pest management science · 2022Article
- Design, Synthesis and Antifungal/Nematicidal Activity of Novel 1,2,4-Oxadiazole Derivatives Containing Amide Fragments.International journal of molecular sciences · 2022Article
- Double Mutations in Succinate Dehydrogenase Are Involved in SDHI Resistance inMicroorganisms · 2022Article
- Shifting sensitivity of septoria tritici blotch compromises field performance and yield of main fungicides in Europe.Frontiers in plant science · 2022Article
- Are Efficient-Dose Mixtures a Solution to Reduce Fungicide Load and Delay Evolution of Resistance? An Experimental Evolutionary Approach.Microorganisms · 2021Article
- Resistance to the SDHI Fungicides Boscalid and Fluopyram inJournal of fungi (Basel, Switzerland) · 2021Article
- Bixafen causes cardiac toxicity in zebrafish (Danio rerio) embryos.Environmental science and pollution research international · 2021Article
- Changes in DMI, SDHI, and QoI Fungicide Sensitivity in the EstonianMicroorganisms · 2021Article
- The Genetic Architecture of Emerging Fungicide Resistance in Populations of a Global Wheat Pathogen.Genome biology and evolution · 2020Article
- Isoflucypram, the first representative of a new succinate dehydrogenase inhibitor fungicide subclass: Its chemical discovery and unusual binding mode.Pest management science · 2020Review
- Sensitivity of theThe plant pathology journal · 2020Article
- Fungicide Sensitivity Shifting ofFrontiers in plant science · 2020Article
- A dispensable paralog of succinate dehydrogenase subunit C mediates standing resistance towards a subclass of SDHI fungicides in Zymoseptoria tritici.PLoS pathogens · 2019Article
- Metyltetraprole, a novel putative complex III inhibitor, targets known QoI-resistant strains of Zymoseptoria tritici and Pyrenophora teres.Pest management science · 2019Article
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Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA new generation of more active succinate dehydrogenase (Sdh) inhibitors (SDHIs) is currently widely used to control Septoria leaf blotch in northwest Europe. Detailed studies were conducted on Zymoseptoria tritici field isolates with reduced sensitivity to fluopyram and isofetamid; SDHIs which have only just or not been introduced for cereal disease control, respectively.
resultsStrong cross-resistance between fluopyram and isofetamid, but not with other SDHIs, was confirmed through sensitivity tests using laboratory mutants and field isolates with and without Sdh mutations. The sensitivity profiles of most field isolates resistant to fluopyram and isofetamid were very similar to a lab mutant carrying SdhC-A84V, but no alterations were found in SdhB, C and D. Inhibition of mitochondrial Sdh enzyme activity and control efficacy in planta for those isolates was severely impaired by fluopyram and isofetamid, but not by bixafen. Isolates with similar phenotypes were not only detected in northwest Europe but also in New Zealand before the widely use of SDHIs.
conclusionThis is the first report of SDHI-specific non-target site resistance in Z. tritici. Monitoring studies show that this resistance mechanism is present and can be selected from standing genetic variation in field populations. © 2017 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
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