Evidence map›Paper›PMID 29024220›Full record

ArticleMolecular reproduction and development2017

Differential expression of key subunits of SWI/SNF chromatin remodeling complexes in porcine embryos derived in vitro or in vivo.

Birgit Cabot, Yu-Chun Tseng, Jennifer S Crodian, Ryan Cabot

Open access · hybridAbstract read
In one paragraph

Article in Molecular reproduction and development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Birgit CabotDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana.ORCID 0000-0003-3270-0194
Yu-Chun TsengDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana.
Jennifer S CrodianDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana.
Ryan CabotDepartment of Animal Sciences, Purdue University, West Lafayette, Indiana.ORCID 0000-0002-4790-9655
Purdue University West Lafayette · US

Funding

Developmental Requirements of SWI/SNF Chromatin Remodeling Complexes in Porcine EmbryosR01HD084309 · NICHD · PURDUE UNIVERSITY · PI CABOT, RYAN A · 2015 to 2019
$1.6M
NICHD NIH HHS R01 HD084309
6 · The paper itself

Abstract

In vitro embryo production is an established method for both humans and animals, but is fraught with inferior development and health issues in offspring born after in vitro fertilization procedures. Analysis of epigenetic changes caused by exposure to in vitro conditions should shed light on potential sources of these phenotypes. Using immunocytochemistry, we investigated the localization and relative abundance of components associated with the SWI/SNF (Switch/Sucrose non-fermentable) chromatin-remodeling complex-including BAF155, BAF170, BAF180, BAF53A, BAF57, BAF60A, BAF45D, ARID1A, ARID1B, ARID2, SNF5, and BRD7-in oocytes and in in vitro-produced and in vivo-derived porcine embryos. Differences in the localization of BAF155, BAF170, BAF60A, and ARID1B among these sources indicate that improper timing of chromatin remodeling and cellular differentiation might occur in early preimplantation embryos produced and cultured in vitro.

Indexed as

AnimalsBlastocystChromatin Assembly and DisassemblyGene Expression Regulation, DevelopmentalMultiprotein ComplexesSwineMultiprotein ComplexesARIDBAF155/170epigeneticspreimplantation embryo

Identifiers

PMID29024220
PMCPMC5760298
OpenAlexW2762148629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.