Evidence map›Paper›PMID 29024066›Full record

ArticleMagnetic resonance in medicine2018

A comparison of exogenous and endogenous CEST MRI methods for evaluating in vivo pH.

Leila R Lindeman, Edward A Randtke, Rachel A High, Kyle M Jones, Christine M Howison, Mark D Pagel

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

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  13. Imaging Techniques in Pharmacological Precision Medicine.Handbook of experimental pharmacology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Leila R LindemanCancer Biology Graduate Interdisciplinary Program, University of Arizona Cancer Center, Tucson, Arizona, USA.
Edward A RandtkeDepartment of Medical Imaging, University of Arizona, Tucson, Arizona, USA.
Rachel A HighCancer Biology Graduate Interdisciplinary Program, University of Arizona Cancer Center, Tucson, Arizona, USA.
Kyle M JonesDepartment of Biomedical Engineering, University of Arizona, Tucson, Arizona, USA.
Christine M HowisonDepartment of Medical Imaging, University of Arizona, Tucson, Arizona, USA.
Mark D PagelCancer Biology Graduate Interdisciplinary Program, University of Arizona Cancer Center, Tucson, Arizona, USA.

Funding

VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Dan Theodorescu · 1985 to 2026
$110.2M
Integrative Cancer Scholars Training GrantT32CA009213 · NCI · UNIVERSITY OF ARIZONA · PI CAREW, JENNIFER S, CURIEL-LEWANDROWSKI, CLARA · 1985 to 2024
$8.6M
MULTIDISCIPLINARY TRAINING IN PULMONARY RESEARCHT32HL066988 · NHLBI · UNIVERSITY OF ROCHESTER · PI GEORAS, STEVE N, O'REILLY, MICHAEL A · 2001 to 2021
$8.1M
Cardiovascular Biomedical Engineering Training GrantT32HL007955 · NHLBI · UNIVERSITY OF ARIZONA · PI BARTON, JENNIFER KEHLET · 2001 to 2020
$5.1M
Measuring extracellular pH in pre-clinical tumor models with CEST MRIR01CA167183 · NCI · UNIVERSITY OF ARIZONA · PI PAGEL, MARK DAVID · 2012 to 2015
$1.6M
Early phase clinical trial for imaging tumor acidosis in breast cancer patients using acidoCEST MRIR01CA197029 · NCI · UNIVERSITY OF ARIZONA · PI CARDENAS-RODRIGUEZ, JULIO · 2015 to 2016
$701k
NCI NIH HHS P30 CA023074NCI NIH HHS R01 CA167183NCI NIH HHS R01 CA197029NCI NIH HHS T32 CA009213NHLBI NIH HHS T32 HL007955NHLBI NIH HHS T32 HL066988
6 · The paper itself

Abstract

purposeExtracellular pH (pHe) is an important biomarker for cancer cell metabolism. Acido-chemical exchange saturation transfer (CEST) MRI uses the contrast agent iopamidol to create spatial maps of pHe. Measurements of amide proton transfer exchange rates (k

methodsSpatial maps of pHe and k

resultsThe k

conclusionMeasurements of k

Indexed as

AcidosisAnimalsFemaleHydrogen-Ion ConcentrationImage Interpretation, Computer-AssistedIopamidolKidneyLung NeoplasmsMagnetic Resonance ImagingMiceMice, NudeNeoplasmsIopamidolCEST MRIlung imagingtumor acidosis

Identifiers

PMID29024066
PMCPMC5821269

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.