ArticleAnnals of neurology2017
Traumatic brain injury in the prodromal period of Parkinson's disease: A large epidemiological study using medicare data.
Article in Annals of neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Traumatic brain injury and risk of Parkinson's disease: a meta-analysis.Acta neurologica Belgica · 2023Pooled it
- Early bone health assessment is indicated in Parkinson's: Risk factor analysis in a UK population-based cohort study.Journal of Parkinson's disease · 2026Article
- Excess risk of fracture in incident Parkinson's disease Medicare beneficiaries.Injury epidemiology · 2026Article
- Lasting Impact: Exploring the Brain Mechanisms that Link Traumatic Brain Injury to Parkinson's Disease.Molecular neurobiology · 2025Review
- The design and development of LRRK2 inhibitors as novel therapeutics for Parkinson's disease.Future medicinal chemistry · 2025Review
- Acupuncture for Parkinson's Disease: A Narrative Review of Clinical Efficacy and Mechanistic Insights.Neuropsychiatric disease and treatment · 2025Review
- Systematic Review of Post-Traumatic Parkinsonism, an Emerging Parkinsonian Disorder Among Survivors of Traumatic Brain Injury.Neurotrauma reports · 2024Article
- Reactive gliosis in traumatic brain injury: a comprehensive review.Frontiers in cellular neuroscience · 2024Review
- A predictive algorithm to identify ever smoking in medical claims-based epidemiologic studies.Annals of epidemiology · 2023Article
- Traumatic brain injury and the development of parkinsonism: Understanding pathophysiology, animal models, and therapeutic targets.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022Review
- Disorders of Movement due to Acquired and Traumatic Brain Injury.Current physical medicine and rehabilitation reports · 2022Review
- Article
- Dream enactment behavior-a real nightmare: a review of post-traumatic stress disorder, REM sleep behavior disorder, and trauma-associated sleep disorder.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Review
- Fractures in the prodromal period of Parkinson disease.Neurology · 2020Article
- G2019S-LRRK2 mutation enhances MPTP-linked Parkinsonism in mice.Human molecular genetics · 2020Article
- Article
- Herpesvirus Infections and Risk of Parkinson's Disease.Neuro-degenerative diseases · 2020Article
- New awakenings: current understanding of sleep dysfunction and its treatment in Parkinson's disease.Journal of neurology · 2020Review
- Validation of a Parkinson Disease Predictive Model in a Population-Based Study.Parkinson's disease · 2020Article
- Early and Accurate Identification of Parkinson Disease Among US Veterans.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveStudies suggest a greater risk of Parkinson's disease (PD) after traumatic brain injury (TBI), but it is possible that the risk of TBI is greater in the prodromal period of PD. We aimed to examine the time-to-TBI in PD patients in their prodromal period compared to population-based controls.
methodsWe identified 89,790 incident PD cases and 118,095 comparable controls aged > 65 years in 2009 using Medicare claims data. Using data from the preceding 5 years, we compared time-to-TBI in PD patients in their prodromal period to controls. We estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for TBI in a Cox regression, while adjusting for age, sex, race/ethnicity, modified Charlson comorbidity index, smoking, and alcohol use.
resultsRisk of TBI was greater in PD patients in their prodromal period across all age and sex groups, with HRs consistently increasing with proximity to PD diagnosis. HRs ranged from 1.64 (95% CI, 1.52, 1.77) 5 years preceding diagnosis to 3.93 (95% CI, 3.74, 4.13) in the year before. The interaction between PD, TBI, and time was primarily observed for TBI attributed to falls. Motor dysfunction and cognitive impairment, suggested by corresponding International Classification of Diseases, Ninth Revision codes, partially mediated the PD-TBI association.
interpretationThere is a strong association between PD and a recent TBI in the prodromal period of PD. This association strengthens as PD diagnosis approaches and may be a result of undetected nonmotor and motor symptoms, but confirmation will be required. Ann Neurol 2017;82:744-754.
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