Evidence map›Paper›PMID 29023830›Full record

ArticleBritish journal of clinical pharmacology2018

Drug management in acute kidney disease - Report of the Acute Disease Quality Initiative XVI meeting.

Marlies Ostermann, Lakhmir S Chawla, Lui G Forni, Sandra L Kane-Gill, John A Kellum, Jay Koyner, Patrick T Murray, Claudio Ronco, Stuart L Goldstein, ADQI 16 workgroup

Open access · bronzeAbstract read
In one paragraph

Article in British journal of clinical pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Article
  4. Review
  5. Acute kidney injury and postoperative delirium.Journal of biomedical research · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Medication Management in the Critically Ill Patient with Acute Kidney Injury.Clinical journal of the American Society of Nephrology : CJASN · 2023
    Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 4 countries.

Marlies OstermannDepartment of Intensive Care, King's College London, Guy's & St Thomas' NHS Foundation Hospital, London, UK.ORCID 0000-0001-9500-9080
Lakhmir S ChawlaDepartment of Medicine, Veterans Affairs Medical Center, Washington, DC, USA.
Lui G ForniIntensive Care Unit, Royal Surrey County Hospital NHS Foundation Trust, Guildford, UK.
Sandra L Kane-GillUniversity of Pittsburgh School of Pharmacy, Pittsburgh, USA.
John A KellumCenter for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, USA.
Jay KoynerDepartment of Medicine, University of Chicago, Chicago, USA.
Patrick T MurrayUCD School of Medicine, Health Sciences Centre, University College Dublin, Dublin, Ireland.
Claudio RoncoDepartment of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, International Renal Research Institute of Vicenza, Vicenza, Italy.
Stuart L GoldsteinCincinnati Children's Hospital Medical Center, Division of Nephrology and Hypertension, Cincinnati, USA.
ADQI 16 workgroup
University of Pittsburgh · USCincinnati Children's Hospital Medical Center · USInternational Renal Research Institute of Vicenza · ITKing's College London · GBRoyal Surrey County Hospital · GBUniversity College Dublin · IEUniversity of Chicago · USVeterans Health Administration · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo summarize and extend the main conclusions and recommendations relevant to drug management during acute kidney disease (AKD) as agreed at the 16

methodsUsing a modified Delphi method to achieve consensus, experts attending the 16

resultsWe recommend that medication reconciliation should occur at admission and discharge, at AKD diagnosis and change in AKD phase, and when the patient's condition changes. Strategies to avoid adverse drug reactions in AKD should seek to minimize adverse events from overdosing and nephrotoxicity and therapeutic failure from under-dosing or incorrect drug selection. Medication regimen assessment or introduction of medications during the AKD period should consider the nephrotoxic potential, altered renal and nonrenal elimination, the effects of toxic metabolites and drug interactions and altered pharmacodynamics in AKD. A dynamic monitoring plan including repeated serial assessment of clinical features, utilization of renal diagnostic tests and therapeutic drug monitoring should be used to guide medication regimen assessment.

conclusionsDrug management during different phases of AKD requires an individualized approach and frequent re-assessment. More research is needed to avoid drug associated harm and therapeutic failure.

Indexed as

Disease ManagementAcute Kidney InjuryConsensus Statements as TopicHumansKidney Function TestsPractice Guidelines as Topicacute kidney diseaseacute kidney injurydrug managementdrugs

Identifiers

PMID29023830
PMCPMC5777429
OpenAlexW2785782091

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.