ArticlePloS one2017
Trace metal release after minimally-invasive repair of pectus excavatum.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- In-vivo toxicokinetics of chromium in human blood and urine after intravenous injection of chromate.Archives of toxicology · 2026Article
- Increased chromium and molybdenum blood levels after minimally-invasive repair of pectus excavatum.Pediatric surgery international · 2026Article
- Titanium nitride coating of pectus bar increases metal contamination after minimally-invasive repair of pectus excavatum.PloS one · 2023Article
- Nickel contamination after minimally-invasive repair of pectus excavatum persists after bar removal.PloS one · 2022Article
- Blood metal levels after minimally invasive repair of pectus excavatum.Interactive cardiovascular and thoracic surgery · 2021Article
- Ropivacaine has no advantage over bupivacaine in thoracic epidural analgesia for patients with pectus excavatum undergoing the Nuss procedure - a single blind randomized clinical trial comparing efficacy and safety.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral studies have shown a high incidence of metal allergy after minimally-invasive repair of pectus excavatum (MIRPE). We postulated that MIRPE is associated with a significant release of trace metal ions, possibly causing the allergic symptoms.
methodsWe evaluated the concentration with chromium, cobalt and nickel in blood, urine and tissue in patients prior to MIRPE and in patients who underwent an explantation of the stainless-steel bar(s) after three years.
resultsOur study group consisted of 20 patients (mean age 19 years) who had bar explantation and our control group included 20 patients (mean age 16 years) prior to MIRPE. At the time of bar removal we detected significantly elevated concentrations of chromium and nickel in the tissue compared to patients prior to the procedure (p<0,001). We also found a significant increase in the levels of chromium in urine and nickel in blood in patients three years post MIRPE (p<0,001). Four patients temporarily developed symptoms of metal allergy, all had elevated metal values in blood and urine at explantation.
conclusionsMinimally-invasive repair of pectus excavatum can lead to a significant trace metal exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.